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Pde8b phosphodiesterase 8B [ Mus musculus (house mouse) ]

Gene ID: 218461, updated on 8-Feb-2024

Summary

Official Symbol
Pde8bprovided by MGI
Official Full Name
phosphodiesterase 8Bprovided by MGI
Primary source
MGI:MGI:2443999
See related
Ensembl:ENSMUSG00000021684 AllianceGenome:MGI:2443999
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B230331L10Rik; C030047E14Rik
Summary
Enables 3',5'-cyclic-AMP phosphodiesterase activity. Acts upstream of or within several processes, including behavioral fear response; learning; and negative regulation of steroid hormone biosynthetic process. Is expressed in several structures, including alimentary system; central nervous system; hindlimb digit; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease. Orthologous to human PDE8B (phosphodiesterase 8B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 17.9), cortex adult (RPKM 8.4) and 9 other tissues See more
Orthologs
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Genomic context

See Pde8b in Genome Data Viewer
Location:
13 D1; 13 49.22 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (95160962..95386904, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (95024105..95250401, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41024 Neighboring gene WD repeat domain 41 Neighboring gene predicted gene, 48350 Neighboring gene predicted gene, 41025 Neighboring gene STARR-positive B cell enhancer ABC_E10808 Neighboring gene small nucleolar RNA, H/ACA box 47 Neighboring gene predicted gene, 22661 Neighboring gene zinc finger, BED type containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
Names
cell proliferation-inducing gene 22 protein
NP_001164140.1
NP_001333711.1
NP_001360932.1
NP_001360933.1
NP_001360934.1
NP_001360935.1
NP_001360936.1
NP_001391617.1
NP_001391618.1
NP_001391619.1
NP_001391620.1
NP_001391621.1
NP_001391622.1
NP_001391623.1
NP_001391624.1
NP_001391625.1
NP_758467.2
XP_006517650.1
XP_006517651.1
XP_006517654.1
XP_006517657.1
XP_011242951.1
XP_011242952.1
XP_011242953.1
XP_017170982.1
XP_017170983.1
XP_030103093.1
XP_030103095.1
XP_030103096.1
XP_036013910.1
XP_036013911.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170669.2NP_001164140.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    Consensus CDS
    CCDS49331.1
    UniProtKB/TrEMBL
    E9PYP0, Q8BI47
    Related
    ENSMUSP00000124068.2, ENSMUST00000162292.8
    Conserved Domains (3) summary
    PHA02597
    Location:158311
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:517764
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
  2. NM_001346782.2NP_001333711.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    Consensus CDS
    CCDS84052.1
    UniProtKB/TrEMBL
    A6YR19, E9PX38
    Related
    ENSMUSP00000124704.2, ENSMUST00000162153.9
  3. NM_001374003.1NP_001360932.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    UniProtKB/Swiss-Prot
    E9Q4S1
    Related
    ENSMUSP00000128987.2, ENSMUST00000172104.8
    Conserved Domains (4) summary
    COG2202
    Location:167375
    PAS; PAS domain [Signal transduction mechanisms]
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:614861
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:280377
    PAS_9; PAS domain
  4. NM_001374004.1NP_001360933.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    UniProtKB/Swiss-Prot
    E9Q4S1
    Related
    ENSMUSP00000070465.8, ENSMUST00000067082.14
    Conserved Domains (4) summary
    COG2202
    Location:166374
    PAS; PAS domain [Signal transduction mechanisms]
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:613860
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:279376
    PAS_9; PAS domain
  5. NM_001374005.1NP_001360934.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    UniProtKB/TrEMBL
    Q8CFW8
    Conserved Domains (2) summary
    PHA02597
    Location:54207
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:413660
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  6. NM_001374006.1NP_001360935.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    UniProtKB/TrEMBL
    Q8CFW8
    Conserved Domains (2) summary
    PHA02597
    Location:53206
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:412659
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  7. NM_001374007.1NP_001360936.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    UniProtKB/TrEMBL
    A6YR19
    Conserved Domains (3) summary
    COG2202
    Location:63274
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:510757
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:176273
    PAS_9; PAS domain
  8. NM_001404688.1NP_001391617.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    UniProtKB/Swiss-Prot
    E9Q4S1
  9. NM_001404689.1NP_001391618.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    UniProtKB/Swiss-Prot
    E9Q4S1
  10. NM_001404690.1NP_001391619.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    UniProtKB/TrEMBL
    Q8BI47
  11. NM_001404691.1NP_001391620.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    UniProtKB/TrEMBL
    Q8CFW8
  12. NM_001404692.1NP_001391621.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    UniProtKB/TrEMBL
    Q8CFW8
  13. NM_001404693.1NP_001391622.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    UniProtKB/TrEMBL
    Q8CFW8
  14. NM_001404694.1NP_001391623.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    UniProtKB/TrEMBL
    Q8CFW8
  15. NM_001404695.1NP_001391624.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    UniProtKB/TrEMBL
    Q8CFW8
  16. NM_001404696.1NP_001391625.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    UniProtKB/TrEMBL
    Q8CFW8
  17. NM_172263.3NP_758467.2  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123034, AC134439, AC147108
    Consensus CDS
    CCDS49332.1
    UniProtKB/TrEMBL
    E9PXX4, Q8CFW8
    Related
    ENSMUSP00000124409.2, ENSMUST00000162412.8
    Conserved Domains (4) summary
    smart00091
    Location:168212
    PAS; PAS domain
    COG2202
    Location:62212
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:459706
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:174227
    PAS_9; PAS domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    95160962..95386904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247236.2XP_030103096.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X8

    UniProtKB/TrEMBL
    A6YR19
    Conserved Domains (2) summary
    pfam00233
    Location:430677
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:96193
    PAS_9; PAS domain
  2. XM_030247233.2XP_030103093.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X4

    UniProtKB/TrEMBL
    A6YR19
    Conserved Domains (3) summary
    COG2202
    Location:87295
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:534781
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:200297
    PAS_9; PAS domain
  3. XM_036158017.1XP_036013910.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X10

    UniProtKB/TrEMBL
    A6YR19
    Conserved Domains (1) summary
    pfam00233
    Location:383630
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  4. XM_011244649.4XP_011242951.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X7

    See identical proteins and their annotated locations for XP_011242951.1

    UniProtKB/TrEMBL
    A6YR19
    Conserved Domains (3) summary
    COG2202
    Location:43254
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:490737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:156253
    PAS_9; PAS domain
  5. XM_006517594.5XP_006517657.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X7

    See identical proteins and their annotated locations for XP_006517657.1

    UniProtKB/TrEMBL
    A6YR19
    Conserved Domains (3) summary
    COG2202
    Location:43254
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:490737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:156253
    PAS_9; PAS domain
  6. XM_030247235.2XP_030103095.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X8

    UniProtKB/TrEMBL
    A6YR19
    Conserved Domains (2) summary
    pfam00233
    Location:430677
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:96193
    PAS_9; PAS domain
  7. XM_011244650.4XP_011242952.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X8

    UniProtKB/TrEMBL
    A6YR19
    Conserved Domains (2) summary
    pfam00233
    Location:430677
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:96193
    PAS_9; PAS domain
  8. XM_006517591.5XP_006517654.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X5

    UniProtKB/TrEMBL
    A6YR19
    Conserved Domains (3) summary
    COG2202
    Location:86294
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:533780
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:199296
    PAS_9; PAS domain
  9. XM_036158018.1XP_036013911.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X11

    UniProtKB/TrEMBL
    A6YR19
    Conserved Domains (2) summary
    pfam00233
    Location:376623
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:42139
    PAS_9; PAS domain
  10. XM_017315494.3XP_017170983.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X12

    UniProtKB/TrEMBL
    Q8CFW8
    Conserved Domains (2) summary
    pfam00233
    Location:326573
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:4295
    PAS_9; PAS domain
  11. XM_011244651.4XP_011242953.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X11

    UniProtKB/TrEMBL
    A6YR19
    Conserved Domains (2) summary
    pfam00233
    Location:376623
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:42139
    PAS_9; PAS domain
  12. XM_017315493.3XP_017170982.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X9

    UniProtKB/TrEMBL
    Q8CFW8
    Conserved Domains (2) summary
    PHA02597
    Location:34187
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:393640
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  13. XM_006517588.5XP_006517651.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X2

    UniProtKB/Swiss-Prot
    E9Q4S1
    Conserved Domains (2) summary
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:566813
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  14. XM_006517587.5XP_006517650.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1

    UniProtKB/Swiss-Prot
    E9Q4S1
    UniProtKB/TrEMBL
    E9Q8J6
    Related
    ENSMUSP00000022192.6, ENSMUST00000022192.12
    Conserved Domains (2) summary
    pfam08629
    Location:147
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:567814
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase