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GTPBP10 GTP binding protein 10 [ Homo sapiens (human) ]

Gene ID: 85865, updated on 5-Sep-2021

Summary

Official Symbol
GTPBP10provided by HGNC
Official Full Name
GTP binding protein 10provided by HGNC
Primary source
HGNC:HGNC:25106
See related
Ensembl:ENSG00000105793 MIM:610920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ObgH2; UG0751c10
Summary
Small G proteins, such as GTPBP10, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in thyroid (RPKM 3.6), kidney (RPKM 2.6) and 25 other tissues See more
Orthologs
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Genomic context

See GTPBP10 in Genome Data Viewer
Location:
7q21.13
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (90346716..90391453)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (89976030..90020767)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 69 Neighboring gene family with sequence similarity 237 member B Neighboring gene uncharacterized LOC107986715 Neighboring gene uncharacterized LOC101927446 Neighboring gene uncharacterized LOC112267985 Neighboring gene cell division cycle 42 pseudogene Neighboring gene claudin 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38242, MGC104191, DKFZp686A10121

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding HDA PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
GTP-binding protein 10
Names
GTP binding protein 10 (putative)
protein obg homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042717.3NP_001036182.1  GTP-binding protein 10 isoform 1

    See identical proteins and their annotated locations for NP_001036182.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks alternate in-frame exons in the 5' coding region, compared to variant 2. The resulting protein (isoform 1) is shorter when it is compared to isoform 2.
    Source sequence(s)
    AC006153, AK095561, AK125553, AK294325, T65158
    Consensus CDS
    CCDS43614.1
    UniProtKB/Swiss-Prot
    A4D1E9
    Related
    ENSP00000257659.8, ENST00000257659.12
    Conserved Domains (2) summary
    cd01898
    Location:77264
    Obg; Obg GTPase
    TIGR00231
    Location:77262
    small_GTP; small GTP-binding protein domain
  2. NM_033107.4NP_149098.2  GTP-binding protein 10 isoform 2

    See identical proteins and their annotated locations for NP_149098.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and it encodes the longer protein (isoform 2)
    Source sequence(s)
    AC002064, AC006153, AK095561, AK125553, AK294325, T65158
    Consensus CDS
    CCDS5617.1
    UniProtKB/Swiss-Prot
    A4D1E9
    Related
    ENSP00000222511.7, ENST00000222511.11
    Conserved Domains (3) summary
    cd01898
    Location:149343
    Obg; Obg GTPase
    PRK12299
    Location:6351
    obgE; GTPase CgtA; Reviewed
    pfam01018
    Location:25145
    GTP1_OBG; GTP1/OBG

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    90346716..90391453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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