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CDK14 cyclin dependent kinase 14 [ Homo sapiens (human) ]

Gene ID: 5218, updated on 25-Aug-2018

Summary

Official Symbol
CDK14provided by HGNC
Official Full Name
cyclin dependent kinase 14provided by HGNC
Primary source
HGNC:HGNC:8883
See related
Ensembl:ENSG00000058091 MIM:610679; Vega:OTTHUMG00000023649
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PFTK1; PFTAIRE1
Summary
PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in brain (RPKM 6.5), kidney (RPKM 3.1) and 24 other tissues See more
Orthologs

Genomic context

See CDK14 in Genome Data Viewer
Location:
7q21.13
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (90595732..91210590)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (90225681..90839905)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267985 Neighboring gene claudin 12 Neighboring gene uncharacterized LOC102723899 Neighboring gene TVP23C pseudogene 1 Neighboring gene VISTA enhancer hs1627 Neighboring gene VISTA enhancer hs1628 Neighboring gene VISTA enhancer hs1633 Neighboring gene protein tyrosine phosphatase type IVA, member 1 pseudogene 3 Neighboring gene VISTA enhancer hs1631 Neighboring gene heart enhancer 20 Neighboring gene frizzled class receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat specifically associates with CDK14 promoter to upregulate CDK14 expression in T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0834

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin binding IPI
Inferred from Physical Interaction
more info
PubMed 
cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytoplasmic cyclin-dependent protein kinase holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase 14
Names
PFTAIRE protein kinase 1
cell division protein kinase 14
serine/threonine-protein kinase PFTAIRE-1
NP_001274064.1
NP_001274065.1
NP_001274066.1
NP_036527.1
XP_005250493.1
XP_005250495.1
XP_005250496.1
XP_011514608.1
XP_011514609.1
XP_016867809.1
XP_016867810.1
XP_016867811.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287135.1NP_001274064.1  cyclin-dependent kinase 14 isoform a

    See identical proteins and their annotated locations for NP_001274064.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB020641, AF119833, AK297974, BC136477, BC152436, BM740394, BP336072, DB476188, DC420282, HY179664
    Consensus CDS
    CCDS75626.1
    UniProtKB/Swiss-Prot
    O94921
    Related
    ENSP00000369390.3, OTTHUMP00000025267, ENST00000380050.7, OTTHUMT00000059970
    Conserved Domains (1) summary
    cd07869
    Location:129431
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
  2. NM_001287136.1NP_001274065.1  cyclin-dependent kinase 14 isoform c

    See identical proteins and their annotated locations for NP_001274065.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AB020641, AK295086, AK316026, BC136477, BC152436, BM740394, BP336072, DB476188, DC325068
    Consensus CDS
    CCDS75627.1
    UniProtKB/Swiss-Prot
    O94921
    Related
    ENSP00000385034.1, OTTHUMP00000196961, ENST00000406263.5, OTTHUMT00000140390
    Conserved Domains (1) summary
    cd07869
    Location:83385
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
  3. NM_001287137.1NP_001274066.1  cyclin-dependent kinase 14 isoform d

    See identical proteins and their annotated locations for NP_001274066.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AB020641, AK296406, AK316026, BC136477, BC152436, BM740394, BP336072, DB476188, DC325068
    Consensus CDS
    CCDS75628.1
    UniProtKB/Swiss-Prot
    O94921
    UniProtKB/TrEMBL
    B4DK59, E7EUK8
    Related
    ENSP00000398936.2, ENST00000436577.3
    Conserved Domains (1) summary
    cl21453
    Location:25302
    PKc_like; Protein Kinases, catalytic domain
  4. NM_012395.3NP_036527.1  cyclin-dependent kinase 14 isoform b

    See identical proteins and their annotated locations for NP_036527.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AB020641, BC136477, BC152436, BM740394, BP336072, DB476188
    Consensus CDS
    CCDS5619.1
    UniProtKB/Swiss-Prot
    O94921
    Related
    ENSP00000265741.3, OTTHUMP00000068098, ENST00000265741.7, OTTHUMT00000140389
    Conserved Domains (2) summary
    cd07869
    Location:111413
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
    PLN00009
    Location:115404
    PLN00009; cyclin-dependent kinase A; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    90595732..91210590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516306.3XP_011514608.1  cyclin-dependent kinase 14 isoform X1

    See identical proteins and their annotated locations for XP_011514608.1

    UniProtKB/Swiss-Prot
    O94921
    Conserved Domains (1) summary
    cd07869
    Location:129431
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
  2. XM_011516307.3XP_011514609.1  cyclin-dependent kinase 14 isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:135277
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:134276
    PKc_like; Protein Kinases, catalytic domain
  3. XM_017012320.1XP_016867809.1  cyclin-dependent kinase 14 isoform X3

    UniProtKB/Swiss-Prot
    O94921
    Conserved Domains (1) summary
    cd07869
    Location:83385
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
  4. XM_005250436.3XP_005250493.1  cyclin-dependent kinase 14 isoform X2

    Conserved Domains (2) summary
    cd07869
    Location:110412
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
    PLN00009
    Location:114403
    PLN00009; cyclin-dependent kinase A; Provisional
  5. XM_005250439.2XP_005250496.1  cyclin-dependent kinase 14 isoform X3

    See identical proteins and their annotated locations for XP_005250496.1

    UniProtKB/Swiss-Prot
    O94921
    Conserved Domains (1) summary
    cd07869
    Location:83385
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
  6. XM_017012322.1XP_016867811.1  cyclin-dependent kinase 14 isoform X3

    UniProtKB/Swiss-Prot
    O94921
    Conserved Domains (1) summary
    cd07869
    Location:83385
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
  7. XM_017012321.2XP_016867810.1  cyclin-dependent kinase 14 isoform X3

    UniProtKB/Swiss-Prot
    O94921
    Conserved Domains (1) summary
    cd07869
    Location:83385
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
  8. XM_005250438.4XP_005250495.1  cyclin-dependent kinase 14 isoform X3

    See identical proteins and their annotated locations for XP_005250495.1

    UniProtKB/Swiss-Prot
    O94921
    Conserved Domains (1) summary
    cd07869
    Location:83385
    STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase

RNA

  1. XR_927477.3 RNA Sequence

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