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MKNK1 MAP kinase interacting serine/threonine kinase 1 [ Homo sapiens (human) ]

Gene ID: 8569, updated on 20-Jan-2019

Summary

Official Symbol
MKNK1provided by HGNC
Official Full Name
MAP kinase interacting serine/threonine kinase 1provided by HGNC
Primary source
HGNC:HGNC:7110
See related
Ensembl:ENSG00000079277 MIM:606724
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MNK1
Summary
This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in appendix (RPKM 4.8), pancreas (RPKM 4.3) and 25 other tissues See more
Orthologs

Genomic context

See MKNK1 in Genome Data Viewer
Location:
1p33
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (46557407..46604311, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47023079..47069966, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 275 Neighboring gene MKNK1 antisense RNA 1 Neighboring gene kinocilin Neighboring gene MOB kinase activator 3C Neighboring gene uncharacterized LOC105378697

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression, organism-specific biosystem (from WikiPathways)
    4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression, organism-specific biosystemThis pathway is modeled after Figure 7 in the article ''Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids'' (See Bibliogr...
  • BDNF-TrkB Signaling, organism-specific biosystem (from WikiPathways)
    BDNF-TrkB Signaling, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is an important neurotrophin for the regulation of synaptic activity. BDNF-TrkB signaling, TrkB being the receptor of BDNF, is involved in transcription, tran...
  • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
    HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Negative regulation of FGFR1 signaling, organism-specific biosystem (from REACTOME)
    Negative regulation of FGFR1 signaling, organism-specific biosystemOnce activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-m...
  • Negative regulation of FGFR2 signaling, organism-specific biosystem (from REACTOME)
    Negative regulation of FGFR2 signaling, organism-specific biosystemOnce activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-m...
  • Negative regulation of FGFR3 signaling, organism-specific biosystem (from REACTOME)
    Negative regulation of FGFR3 signaling, organism-specific biosystemOnce activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-m...
  • Negative regulation of FGFR4 signaling, organism-specific biosystem (from REACTOME)
    Negative regulation of FGFR4 signaling, organism-specific biosystemOnce activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-m...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by FGFR, organism-specific biosystem (from REACTOME)
    Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR1, organism-specific biosystem (from REACTOME)
    Signaling by FGFR1, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR2, organism-specific biosystem (from REACTOME)
    Signaling by FGFR2, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR3, organism-specific biosystem (from REACTOME)
    Signaling by FGFR3, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR4, organism-specific biosystem (from REACTOME)
    Signaling by FGFR4, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
    Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem
    Signaling mediated by p38-alpha and p38-beta
  • Spry regulation of FGF signaling, organism-specific biosystem (from REACTOME)
    Spry regulation of FGF signaling, organism-specific biosystemSprouty was initially characterized as a negative regulator of FGFR signaling in Drosophila. Human cells contain four genes encoding Sprouty proteins, of which Spry2 is the best studied and most wid...
  • Structural Pathway of Interleukin 1 (IL-1), organism-specific biosystem (from WikiPathways)
    Structural Pathway of Interleukin 1 (IL-1), organism-specific biosystemPathway published in http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003470 IL-1 signaling pathway reconstructed by combining related pathways and information from the litera...
  • p38 MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    p38 MAPK Signaling Pathway, organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
MAP kinase-interacting serine/threonine-protein kinase 1
Names
MAP kinase signal-integrating kinase 1
MAPK signal-integrating kinase 1
NP_001129025.2
XP_006711063.1
XP_006711064.1
XP_006711065.1
XP_006711066.1
XP_006711070.1
XP_006711076.1
XP_006711077.1
XP_006711078.1
XP_016858141.1
XP_016858142.1
XP_016858148.1
XP_016858149.1
XP_016858150.1
XP_016858151.1
XP_024306276.1
XP_024306277.1
XP_024306278.1
XP_024306279.1
XP_024306280.1
XP_024306281.1
XP_024306282.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032029.2 RefSeqGene

    Range
    5001..51888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135553.3NP_001129025.2  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (3) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AB000409, BC002755, BG722049, BM665342, DA502363
    Consensus CDS
    CCDS44134.1
    Related
    ENSP00000498143.1, ENST00000650508.1
    Conserved Domains (1) summary
    cd14174
    Location:34322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  2. NM_003684.6NP_003675.3  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC002755, BG722049, BM665342, DA435648, DC366212
    Consensus CDS
    CCDS538.1
    Related
    ENSP00000498083.1, ENST00000649800.1
    Conserved Domains (1) summary
    cd14174
    Location:34363
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  3. NM_198973.4NP_945324.2  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two coding exons, and uses an alternate donor splice site at the 5' non-coding exon compared to variant 1. The second missing exon results in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK290456, BC002755, BG722049, BM665342, DC376088
    Consensus CDS
    CCDS30705.1
    Related
    ENSP00000497380.1, ENST00000650026.1
    Conserved Domains (1) summary
    cd14174
    Location:34322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

RNA

  1. NR_024174.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks three non-consecutive exons compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with the translation of the longest ORF; translation of the upstream ORF renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK298839, BC002755, BG722049, BM665342
  2. NR_024176.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an additional exon, and lacks two non-consecutive exons compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with the translation of the longest ORF; translation of the upstream ORF renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB000409, AK096423, BG722049, BM665342, BX538193
    Related
    ENST00000342571.7
  3. NR_146512.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in its 5' terminal exon, and contains multiple differences in internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK290456, AL136373, BC002755, BM665342, DB273771

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    46557407..46604311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450513.1XP_024306281.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X8

    Related
    ENSP00000411135.3, ENST00000428112.7
    Conserved Domains (1) summary
    cd14174
    Location:34322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  2. XM_006711000.1XP_006711063.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

    See identical proteins and their annotated locations for XP_006711063.1

    UniProtKB/Swiss-Prot
    Q9BUB5
    Conserved Domains (2) summary
    smart00220
    Location:53333
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14174
    Location:46334
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  3. XM_006711007.1XP_006711070.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5

    See identical proteins and their annotated locations for XP_006711070.1

    Conserved Domains (1) summary
    cl21453
    Location:21279
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006711014.1XP_006711077.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X9

    See identical proteins and their annotated locations for XP_006711077.1

    UniProtKB/TrEMBL
    Q7Z319
    Conserved Domains (2) summary
    smart00220
    Location:33238
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:36239
    PKc_like; Protein Kinases, catalytic domain
  5. XM_017002659.1XP_016858148.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X6

    UniProtKB/Swiss-Prot
    Q9BUB5
    Conserved Domains (2) summary
    smart00220
    Location:53333
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14174
    Location:46334
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  6. XM_006711015.1XP_006711078.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X9

    See identical proteins and their annotated locations for XP_006711078.1

    UniProtKB/TrEMBL
    Q7Z319
    Conserved Domains (2) summary
    smart00220
    Location:33238
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:36239
    PKc_like; Protein Kinases, catalytic domain
  7. XM_017002662.1XP_016858151.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X7

  8. XM_006711003.1XP_006711066.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3

    See identical proteins and their annotated locations for XP_006711066.1

    Conserved Domains (2) summary
    smart00220
    Location:47327
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14174
    Location:40328
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  9. XM_006711013.1XP_006711076.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X9

    See identical proteins and their annotated locations for XP_006711076.1

    UniProtKB/TrEMBL
    Q7Z319
    Related
    ENSP00000339573.6, ENST00000341183.9
    Conserved Domains (2) summary
    smart00220
    Location:33238
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:36239
    PKc_like; Protein Kinases, catalytic domain
  10. XM_024450511.1XP_024306279.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5

    Conserved Domains (1) summary
    cl21453
    Location:21279
    PKc_like; Protein Kinases, catalytic domain
  11. XM_024450509.1XP_024306277.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

    Related
    ENSP00000361013.5, ENST00000371945.9
    Conserved Domains (1) summary
    cd14174
    Location:34322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  12. XM_017002653.1XP_016858142.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:80336
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:79337
    PKc_like; Protein Kinases, catalytic domain
  13. XM_024450512.1XP_024306280.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X8

    Conserved Domains (1) summary
    cd14174
    Location:34322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  14. XM_024450508.1XP_024306276.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

    Conserved Domains (1) summary
    cd14174
    Location:34322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  15. XM_017002661.2XP_016858150.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X7

  16. XM_006711001.3XP_006711064.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3

    See identical proteins and their annotated locations for XP_006711064.1

    Conserved Domains (2) summary
    smart00220
    Location:47327
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14174
    Location:40328
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  17. XM_017002652.2XP_016858141.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:80336
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:79337
    PKc_like; Protein Kinases, catalytic domain
  18. XM_024450510.1XP_024306278.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

    Conserved Domains (1) summary
    cd14174
    Location:34322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  19. XM_017002660.2XP_016858149.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X7

  20. XM_006711002.3XP_006711065.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3

    See identical proteins and their annotated locations for XP_006711065.1

    Conserved Domains (2) summary
    smart00220
    Location:47327
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14174
    Location:40328
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  21. XM_024450514.1XP_024306282.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X8

    Conserved Domains (1) summary
    cd14174
    Location:34322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_024175.1: Suppressed sequence

    Description
    NR_024175.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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