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MKNK1 MAPK interacting serine/threonine kinase 1 [ Homo sapiens (human) ]

Gene ID: 8569, updated on 26-Oct-2022

Summary

Official Symbol
MKNK1provided by HGNC
Official Full Name
MAPK interacting serine/threonine kinase 1provided by HGNC
Primary source
HGNC:HGNC:7110
See related
Ensembl:ENSG00000079277 MIM:606724; AllianceGenome:HGNC:7110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MNK1
Summary
This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in appendix (RPKM 4.8), pancreas (RPKM 4.3) and 25 other tissues See more
Orthologs
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Genomic context

See MKNK1 in Genome Data Viewer
Location:
1p33
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (46557407..46604268, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (46434628..46481501, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47023079..47069940, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr1.5857 Neighboring gene MKNK1 antisense RNA 1 Neighboring gene kinocilin Neighboring gene MOB kinase activator 3C Neighboring gene uncharacterized LOC105378697

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
MAP kinase-interacting serine/threonine-protein kinase 1
Names
MAP kinase interacting serine/threonine kinase 1
MAP kinase signal-integrating kinase 1
MAPK signal-integrating kinase 1
NP_001129025.2
NP_001364266.1
NP_001364267.1
NP_001364270.1
NP_001364271.1
NP_001364272.1
NP_001364302.1
NP_001364303.1
NP_001364304.1
NP_003675.3
NP_945324.2
XP_006711065.1
XP_016858149.1
XP_024306278.1
XP_047288978.1
XP_047288980.1
XP_047288981.1
XP_047288982.1
XP_047288995.1
XP_047288998.1
XP_047289003.1
XP_047289009.1
XP_047289015.1
XP_047289022.1
XP_047289035.1
XP_047289037.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032029.2 RefSeqGene

    Range
    5027..51888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135553.4NP_001129025.2  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (3) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AB000409, BC002755, BG722049, BM665342, DA502363
    Consensus CDS
    CCDS44134.2
    UniProtKB/TrEMBL
    A0A499FJN1
    Related
    ENSP00000361013.5, ENST00000371945.10
    Conserved Domains (1) summary
    cd14174
    Location:34322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  2. NM_001377337.1NP_001364266.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL136373, KF459523
    Conserved Domains (1) summary
    cd14174
    Location:40328
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  3. NM_001377338.1NP_001364267.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL136373, KF459523
    Conserved Domains (1) summary
    cd14174
    Location:40328
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  4. NM_001377341.1NP_001364270.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL136373, KF459523
    Conserved Domains (1) summary
    cd14174
    Location:40328
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  5. NM_001377342.1NP_001364271.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL136373, KF459523
    Conserved Domains (1) summary
    cd14174
    Location:40328
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  6. NM_001377343.1NP_001364272.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL136373, KF459523
    Conserved Domains (1) summary
    cl21453
    Location:21279
    PKc_like; Protein Kinases, catalytic domain
  7. NM_001377373.1NP_001364302.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL136373, KF459523
    Consensus CDS
    CCDS44134.2
    UniProtKB/TrEMBL
    A0A499FJN1
    Conserved Domains (1) summary
    cd14174
    Location:34322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  8. NM_001377374.1NP_001364303.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL136373, KF459523
    Consensus CDS
    CCDS30705.2
    UniProtKB/TrEMBL
    A0A499FJS1
    Conserved Domains (1) summary
    cd14174
    Location:34322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  9. NM_001377375.1NP_001364304.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL136373, KF459523
    Consensus CDS
    CCDS30705.2
    UniProtKB/TrEMBL
    A0A499FJS1
    Conserved Domains (1) summary
    cd14174
    Location:34322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  10. NM_003684.7NP_003675.3  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC002755, BM665342, DA435648, DC366212
    Consensus CDS
    CCDS538.2
    UniProtKB/TrEMBL
    A0A499FIS5
    Related
    ENSP00000361014.5, ENST00000371946.9
    Conserved Domains (1) summary
    cd14174
    Location:34363
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  11. NM_198973.5NP_945324.2  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two coding exons, and uses an alternate donor splice site at the 5' non-coding exon compared to variant 1. The second missing exon results in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK290456, BC002755, BG722049, BM665342, DC376088
    Consensus CDS
    CCDS30705.2
    UniProtKB/TrEMBL
    A0A499FJS1
    Related
    ENSP00000411135.3, ENST00000428112.7
    Conserved Domains (1) summary
    cd14174
    Location:34322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

RNA

  1. NR_024174.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks three non-consecutive exons compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with the translation of the longest ORF; translation of the upstream ORF renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK298839, BC002755, BM665342
  2. NR_024176.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an additional exon, and lacks two non-consecutive exons compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with the translation of the longest ORF; translation of the upstream ORF renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB000409, AK096423, BG722049, BM665342, BX538193
    Related
    ENST00000342571.7
  3. NR_146512.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in its 5' terminal exon, and contains multiple differences in internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK290456, AL136373, BC002755, BM665342, DB273771
  4. NR_165250.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136373, KF459523

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    46557407..46604268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433047.1XP_047289003.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5

    Related
    ENSP00000339573.6, ENST00000341183.9
  2. XM_047433024.1XP_047288980.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

    Related
    ENSP00000498143.1, ENST00000650508.1
  3. XM_047433026.1XP_047288982.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

  4. XM_047433025.1XP_047288981.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

  5. XM_047433053.1XP_047289009.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5

  6. XM_006711002.4XP_006711065.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3

    See identical proteins and their annotated locations for XP_006711065.1

    Conserved Domains (1) summary
    cd14174
    Location:40328
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  7. XM_047433059.1XP_047289015.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5

  8. XM_017002660.3XP_016858149.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X7

    Conserved Domains (1) summary
    cd14174
    Location:40328
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  9. XM_047433039.1XP_047288995.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

    UniProtKB/TrEMBL
    A0A499FJN1
  10. XM_047433042.1XP_047288998.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

    UniProtKB/TrEMBL
    A0A499FJN1
  11. XM_047433066.1XP_047289022.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X6

  12. XM_047433022.1XP_047288978.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1

  13. XM_024450510.2XP_024306278.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

    UniProtKB/TrEMBL
    A0A499FJN1
    Conserved Domains (1) summary
    cd14174
    Location:34322
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
  14. XM_047433079.1XP_047289035.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X8

  15. XM_047433081.1XP_047289037.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    46434628..46481501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_024175.1: Suppressed sequence

    Description
    NR_024175.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.