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GFM1 G elongation factor mitochondrial 1 [ Homo sapiens (human) ]

Gene ID: 85476, updated on 3-May-2020

Summary

Official Symbol
GFM1provided by HGNC
Official Full Name
G elongation factor mitochondrial 1provided by HGNC
Primary source
HGNC:HGNC:13780
See related
Ensembl:ENSG00000168827 MIM:606639
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EFG; GFM; EFG1; EFGM; EGF1; hEFG1; COXPD1; mtEF-G1
Summary
Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 17.7), thyroid (RPKM 16.7) and 25 other tissues See more
Orthologs

Genomic context

See GFM1 in Genome Data Viewer
Location:
3q25.32
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (158644527..158695581)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (158362286..158410361)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene myeloid leukemia factor 1 Neighboring gene methylthioadenosine phosphorylase pseudogene 1 Neighboring gene latexin Neighboring gene uncharacterized LOC112268457 Neighboring gene retinoic acid receptor responder 1 Neighboring gene cytokine receptor CRL2 Neighboring gene ribosomal protein L35a pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12662, FLJ13632, FLJ20773

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation elongation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial translational elongation IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
elongation factor G, mitochondrial
Names
G translation elongation factor, mitochondrial
mitochondrial elongation factor G
mitochondrial elongation factor G1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008441.1 RefSeqGene

    Range
    5001..53045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001308164.1NP_001295093.1  elongation factor G, mitochondrial isoform 1

    Status: REVIEWED

    Source sequence(s)
    AF309777, AF367998, AK092293
    Consensus CDS
    CCDS77851.1
    UniProtKB/Swiss-Prot
    Q96RP9
    Related
    ENSP00000264263.5, ENST00000264263.9
    Conserved Domains (6) summary
    cd01886
    Location:48339
    EF-G; Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis
    PRK12740
    Location:52751
    PRK12740; elongation factor G; Reviewed
    cd01434
    Location:544660
    EFG_mtEFG1_IV; EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2 ...
    cd04097
    Location:666743
    mtEFG1_C; mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating ...
    cd04091
    Location:372452
    mtEFG1_II_like; Domain II of mitochondrial elongation factor G1-like proteins found in eukaryotes
    cd16262
    Location:466541
    EFG_III; Domain III of Elongation Factor G (EFG)
  2. NM_001308166.1NP_001295095.1  elongation factor G, mitochondrial isoform 3

    Status: REVIEWED

    Source sequence(s)
    AF367998, AK000780
    Consensus CDS
    CCDS82867.1
    UniProtKB/Swiss-Prot
    Q96RP9
    UniProtKB/TrEMBL
    C9IZ01
    Related
    ENSP00000418755.1, ENST00000478576.5
    Conserved Domains (5) summary
    cd01886
    Location:48320
    EF-G; Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis
    pfam00009
    Location:44319
    GTP_EFTU; Elongation factor Tu GTP binding domain
    cd04091
    Location:353433
    mtEFG1_II_like; Domain II of mitochondrial elongation factor G1-like proteins found in eukaryotes
    cd16262
    Location:447522
    EFG_III; Domain III of Elongation Factor G (EFG)
    cl02789
    Location:525588
    EFG_like_IV; Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily ...
  3. NM_001374355.1NP_001361284.1  elongation factor G, mitochondrial isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC080013
  4. NM_001374356.1NP_001361285.1  elongation factor G, mitochondrial isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC080013
  5. NM_001374357.1NP_001361286.1  elongation factor G, mitochondrial isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC080013
  6. NM_001374358.1NP_001361287.1  elongation factor G, mitochondrial isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC080013
  7. NM_001374359.1NP_001361288.1  elongation factor G, mitochondrial isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC080013
  8. NM_001374360.1NP_001361289.1  elongation factor G, mitochondrial isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC080013
  9. NM_001374361.1NP_001361290.1  elongation factor G, mitochondrial isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC080013
  10. NM_024996.7NP_079272.4  elongation factor G, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_079272.4

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC080013
    Consensus CDS
    CCDS33885.1
    UniProtKB/Swiss-Prot
    Q96RP9
    UniProtKB/TrEMBL
    E5KND5
    Related
    ENSP00000419038.1, ENST00000486715.5
    Conserved Domains (1) summary
    PRK12740
    Location:52732
    PRK12740; elongation factor G; Reviewed

RNA

  1. NR_164499.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC080013
  2. NR_164500.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC080013
  3. NR_164501.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC080013
  4. NR_164502.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025033, AC080013
    Related
    ENST00000478254.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    158644527..158695581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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