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Gfm1 G elongation factor, mitochondrial 1 [ Mus musculus (house mouse) ]

Gene ID: 28030, updated on 3-Nov-2024

Summary

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Official Symbol
Gfm1provided by MGI
Official Full Name
G elongation factor, mitochondrial 1provided by MGI
Primary source
MGI:MGI:107339
See related
Ensembl:ENSMUSG00000027774 AllianceGenome:MGI:107339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gfm; D3Wsu133e
Summary
Predicted to enable GTPase activity and translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Located in mitochondrion. Is expressed in embryo and extraembryonic component. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 1. Orthologous to human GFM1 (G elongation factor mitochondrial 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 23.8), placenta adult (RPKM 13.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gfm1 in Genome Data Viewer
Location:
3 E1; 3 30.96 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (67337448..67382401)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (67430115..67475068)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene arginine/serine-rich coiled-coil 1 Neighboring gene predicted gene, 22295 Neighboring gene STARR-seq mESC enhancer starr_07884 Neighboring gene STARR-positive B cell enhancer ABC_E6060 Neighboring gene STARR-positive B cell enhancer mm9_chr3:67177807-67178108 Neighboring gene myeloid leukemia factor 1 Neighboring gene retinoic acid receptor responder (tazarotene induced) 1 Neighboring gene latexin Neighboring gene STARR-seq mESC enhancer starr_07890 Neighboring gene STARR-seq mESC enhancer starr_07891 Neighboring gene predicted gene, 40067 Neighboring gene predicted gene, 35299

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dysfunctional mitochondrial translation and combined oxidative phosphorylation deficiency in a mouse model of hepatoencephalopathy due to Gfm1 mutations. Molina-Berenguer M, et al. FASEB J, 2022 Jan. PMID 34919756
  2. Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis. Almeida L, et al. Immunity, 2021 Jan 12. PMID 33238133, Free PMC Article
  3. Cloning and characterization of human and mouse mitochondrial elongation factor G, GFM and Gfm, and mapping of GFM to human chromosome 3q25.1-q26.2. Gao J, et al. Genomics, 2001 May 15. PMID 11374907
  4. The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins. Hémono M, et al. BMC Biol, 2022 Jan 10. PMID 35012549, Free PMC Article
  5. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dysfunctional mitochondrial translation and combined oxidative phosphorylation deficiency in a mouse model of hepatoencephalopathy due to Gfm1 mutations.
    Title: Dysfunctional mitochondrial translation and combined oxidative phosphorylation deficiency in a mouse model of hepatoencephalopathy due to Gfm1 mutations.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables translation elongation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translational elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial translational elongation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
elongation factor G, mitochondrial
Names
EF-Gmt
G elongation factor 1
elongation factor G 1, mitochondrial
elongation factor G1
mEF-G 1
mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138591.2 → NP_613057.2  elongation factor G, mitochondrial

    See identical proteins and their annotated locations for NP_613057.2

    Status: VALIDATED

    Source sequence(s)
    AC124190
    Consensus CDS
    CCDS38449.1
    UniProtKB/Swiss-Prot
    Q8K0D5, Q921D6, Q924I0
    Related
    ENSMUSP00000076503.7, ENSMUST00000077271.9
    Conserved Domains (6) summary
    cd01886
    Location:49 → 321
    EF-G; Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis
    PRK12740
    Location:53 → 732
    PRK12740; elongation factor G; Reviewed
    cd01434
    Location:525 → 641
    EFG_mtEFG1_IV; EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2 ...
    cd04097
    Location:647 → 724
    mtEFG1_C; mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating ...
    cd04091
    Location:353 → 432
    mtEFG1_II_like; Domain II of mitochondrial elongation factor G1-like proteins found in eukaryotes
    cd16262
    Location:447 → 522
    EFG_III; Domain III of Elongation Factor G (EFG)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    67337448..67382401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K0D5.1 GenPept UniProtKB/Swiss-Prot:Q8K0D5

Gene LinkOut

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