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CIPC CLOCK interacting pacemaker [ Homo sapiens (human) ]

Gene ID: 85457, updated on 5-Aug-2022

Summary

Official Symbol
CIPCprovided by HGNC
Official Full Name
CLOCK interacting pacemakerprovided by HGNC
Primary source
HGNC:HGNC:20365
See related
Ensembl:ENSG00000198894 MIM:616995; AllianceGenome:HGNC:20365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA1737
Summary
Predicted to be involved in negative regulation of circadian rhythm and negative regulation of transcription, DNA-templated. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 21.3), heart (RPKM 15.0) and 25 other tissues See more
Orthologs
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Genomic context

See CIPC in Genome Data Viewer
Location:
14q24.3
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (77098258..77117287)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (71308042..71327053)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77564601..77583630)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2288 Neighboring gene long intergenic non-protein coding RNA 2289 Neighboring gene uncharacterized LOC124903350 Neighboring gene zinc finger DHHC-type palmitoyltransferase 22 Neighboring gene family with sequence similarity 204 member D, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1737

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
CLOCK-interacting pacemaker
Names
CLOCK-interacting circadian protein
CLOCK-interacting protein, circadian

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033426.3NP_219494.2  CLOCK-interacting pacemaker

    See identical proteins and their annotated locations for NP_219494.2

    Status: VALIDATED

    Source sequence(s)
    AC007375, AC007686
    Consensus CDS
    CCDS9855.1
    UniProtKB/Swiss-Prot
    Q8NDZ1, Q9C0C6
    Related
    ENSP00000355319.2, ENST00000361786.7
    Conserved Domains (1) summary
    pfam15800
    Location:38376
    CiPC; Clock interacting protein circadian

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    77098258..77117287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    71308042..71327053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)