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Cipc CLOCK interacting protein, circadian [ Mus musculus (house mouse) ]

Gene ID: 217732, updated on 7-Feb-2023

Summary

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Official Symbol
Cipcprovided by MGI
Official Full Name
CLOCK interacting protein, circadianprovided by MGI
Primary source
MGI:MGI:1919185
See related
Ensembl:ENSMUSG00000034157 AllianceGenome:MGI:1919185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310044G17Rik
Summary
Involved in negative regulation of circadian rhythm and negative regulation of transcription, DNA-templated. Located in nucleus. Orthologous to human CIPC (CLOCK interacting pacemaker). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 17.1), colon adult (RPKM 12.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cipc in Genome Data Viewer
Location:
12; 12 D2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (86993815..87012138)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (86944741..86965364)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26698 Neighboring gene predicted gene, 53735 Neighboring gene predicted gene, 32934 Neighboring gene zinc finger, DHHC-type containing 22 Neighboring gene transmembrane protein 63c Neighboring gene crumbs homolog 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inactivation of Cipc alters the expression of Per1 but not circadian rhythms in mice. Qu Z, et al. Sci China Life Sci, 2015 Apr. PMID 25862660
  2. Satellite cell-specific deletion of Cipc alleviates myopathy in mdx mice. Zheng J, et al. Cell Rep, 2022 Jun 14. PMID 35705041
  3. Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription. Yoshitane H, et al. Mol Cell Biol, 2009 Jul. PMID 19414601, Free PMC Article
  4. CIPC is a mammalian circadian clock protein without invertebrate homologues. Zhao WN, et al. Nat Cell Biol, 2007 Mar. PMID 17310242
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

See all (22) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Satellite cell-specific deletion of Cipc alleviates myopathy in mdx mice.
    Title: Satellite cell-specific deletion of Cipc alleviates myopathy in mdx mice.
  2. mRNA expression profiles of core clock genes in the liver of Cipc (-/-) mice showed no significant differences from that in wild-type mice except for Per1
    Title: Inactivation of Cipc alters the expression of Per1 but not circadian rhythms in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Clone Names

  • mKIAA1737, Kiaa1737

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CLOCK-interacting pacemaker
Names
CLOCK-interacting circadian protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289429.2 → NP_001276358.1  CLOCK-interacting pacemaker isoform b

    See identical proteins and their annotated locations for NP_001276358.1

    Status: VALIDATED

    Source sequence(s)
    AC153147
    Conserved Domains (1) summary
    pfam15800
    Location:1 → 317
    CiPC; Clock interacting protein circadian

  2. NM_001289430.2 → NP_001276359.1  CLOCK-interacting pacemaker isoform a

    See identical proteins and their annotated locations for NP_001276359.1

    Status: VALIDATED

    Source sequence(s)
    AC153147
    Consensus CDS
    CCDS56849.1
    UniProtKB/Swiss-Prot
    Q8R0W1
    UniProtKB/TrEMBL
    A0A087WQN1, Z4YJJ0
    Related
    ENSMUSP00000140266.3, ENSMUST00000189246.7
    Conserved Domains (1) summary
    pfam15800
    Location:52 → 388
    CiPC; Clock interacting protein circadian

  3. NM_001289431.2 → NP_001276360.1  CLOCK-interacting pacemaker isoform b

    See identical proteins and their annotated locations for NP_001276360.1

    Status: VALIDATED

    Source sequence(s)
    AC153147
    Conserved Domains (1) summary
    pfam15800
    Location:1 → 317
    CiPC; Clock interacting protein circadian

  4. NM_001289432.2 → NP_001276361.1  CLOCK-interacting pacemaker isoform b

    See identical proteins and their annotated locations for NP_001276361.1

    Status: VALIDATED

    Source sequence(s)
    AC153147
    Conserved Domains (1) summary
    pfam15800
    Location:1 → 317
    CiPC; Clock interacting protein circadian

  5. NM_001364274.2 → NP_001351203.1  CLOCK-interacting pacemaker isoform b

    Status: VALIDATED

    Source sequence(s)
    AC153147
    Conserved Domains (1) summary
    pfam15800
    Location:1 → 317
    CiPC; Clock interacting protein circadian

  6. NM_173735.3 → NP_776096.2  CLOCK-interacting pacemaker isoform a

    See identical proteins and their annotated locations for NP_776096.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Both variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AC153147, AK122546, BI202419, CF530959
    Consensus CDS
    CCDS56849.1
    UniProtKB/Swiss-Prot
    Q8R0W1
    UniProtKB/TrEMBL
    A0A087WQN1, Z4YJJ0
    Related
    ENSMUSP00000038630.5, ENSMUST00000038369.11
    Conserved Domains (1) summary
    pfam15800
    Location:52 → 388
    CiPC; Clock interacting protein circadian

RNA

  1. NR_157110.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153147

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    86993815..87012138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157332.1 → XP_036013225.1  CLOCK-interacting pacemaker isoform X1

    Conserved Domains (1) summary
    pfam15800
    Location:118 → 454
    CiPC; Clock interacting protein circadian

  2. XM_011244079.4 → XP_011242381.1  CLOCK-interacting pacemaker isoform X3

    See identical proteins and their annotated locations for XP_011242381.1

    Conserved Domains (1) summary
    pfam15800
    Location:1 → 317
    CiPC; Clock interacting protein circadian

  3. XM_006515713.5 → XP_006515776.1  CLOCK-interacting pacemaker isoform X3

    See identical proteins and their annotated locations for XP_006515776.1

    Conserved Domains (1) summary
    pfam15800
    Location:1 → 317
    CiPC; Clock interacting protein circadian

  4. XM_036157334.1 → XP_036013227.1  CLOCK-interacting pacemaker isoform X3

    Conserved Domains (1) summary
    pfam15800
    Location:1 → 317
    CiPC; Clock interacting protein circadian

  5. XM_017315031.3 → XP_017170520.1  CLOCK-interacting pacemaker isoform X2

    UniProtKB/TrEMBL
    A0A087WQN1, Z4YJJ0
    Conserved Domains (1) summary
    pfam15800
    Location:52 → 388
    CiPC; Clock interacting protein circadian

  6. XM_036157333.1 → XP_036013226.1  CLOCK-interacting pacemaker isoform X2

    UniProtKB/TrEMBL
    A0A087WQN1
    Conserved Domains (1) summary
    pfam15800
    Location:52 → 388
    CiPC; Clock interacting protein circadian

  7. XM_006515712.5 → XP_006515775.1  CLOCK-interacting pacemaker isoform X2

    See identical proteins and their annotated locations for XP_006515775.1

    UniProtKB/TrEMBL
    A0A087WQN1, Z4YJJ0
    Conserved Domains (1) summary
    pfam15800
    Location:52 → 388
    CiPC; Clock interacting protein circadian
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0W1.4 GenPept UniProtKB/Swiss-Prot:Q8R0W1

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