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CCNB3 cyclin B3 [ Homo sapiens (human) ]

Gene ID: 85417, updated on 13-Feb-2019

Summary

Official Symbol
CCNB3provided by HGNC
Official Full Name
cyclin B3provided by HGNC
Primary source
HGNC:HGNC:18709
See related
Ensembl:ENSG00000147082 MIM:300456
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Expression
Biased expression in testis (RPKM 2.9), brain (RPKM 0.3) and 2 other tissues See more
Orthologs

Genomic context

See CCNB3 in Genome Data Viewer
Location:
Xp11.22
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (50202713..50351914)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (50027540..50094913)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene peptide YY 3 (pseudogene) Neighboring gene A-kinase anchoring protein 4 Neighboring gene diacylglycerol kinase kappa Neighboring gene shroom family member 4 Neighboring gene RNA, U6 small nuclear 935, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr The human Vpr interacting protein (hVIP/MOV34) is a likely cellular cofactor for HIV-1 Vpr inactivation of the cdc2-cyclin B kinase complex and induction of cell cycle arrest PubMed
vpr Data suggests that HIV-1 Vpr transactivation of the HIV-LTR promoter occurs through the inhibition of p300-associated cdc2-cyclin B kinase complex activity which enhances transcriptional activation by Rel A and p300 PubMed
vpr Inactivation of the cdc2-cyclin B kinase complex by HIV-1 Vpr leads to the activation of Poly(A) polymerase PubMed
vpr Inactivation of the cdc2-cyclin B kinase complex and arrest in the G2 phase of the cell cycle has been mapped to the C-terminus of HIV-1 Vpr, including amino acids 73, 80 and 84-96 PubMed
vpr HIV-1 Vpr inactivates the cdc2-cyclin B kinase complex by inactivating cdc25C, the phosphatase that dephosphorylates and activates cdc2 PubMed
vpr HIV-1 Vpr inactivates the cdc2-cyclin B kinase complex by inhibiting the dephosphorylation of cdc2 tyrosine 15, leading to arrest in the G2 phase of the cell cycle PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cell Cycle, organism-specific biosystem (from WikiPathways)
    Cell Cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
  • Cell cycle, organism-specific biosystem (from KEGG)
    Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle, conserved biosystem (from KEGG)
    Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle - G2/M transition, organism-specific biosystem (from KEGG)
    Cell cycle - G2/M transition, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Cell cycle - G2/M transition, conserved biosystem (from KEGG)
    Cell cycle - G2/M transition, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • DNA Damage Response, organism-specific biosystem (from WikiPathways)
    DNA Damage Response, organism-specific biosystemThis is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two ...
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
    Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
  • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
    Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
  • miRNA Regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
    miRNA Regulation of DNA Damage Response, organism-specific biosystemThis is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The...
  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
G2/mitotic-specific cyclin-B3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012880.1 RefSeqGene

    Range
    3367..70740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_033031.2NP_149020.2  G2/mitotic-specific cyclin-B3 isoform 3

    See identical proteins and their annotated locations for NP_149020.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longer transcript and encodes the longer isoform (3).
    Source sequence(s)
    AJ314764, AJ416458
    Consensus CDS
    CCDS14331.1
    UniProtKB/Swiss-Prot
    Q8WWL7
    Related
    ENSP00000276014.7, ENST00000276014.11
    Conserved Domains (2) summary
    pfam00134
    Location:11321257
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:12591375
    Cyclin_C; Cyclin, C-terminal domain
  2. NM_033670.2NP_391990.1  G2/mitotic-specific cyclin-B3 isoform 1

    See identical proteins and their annotated locations for NP_391990.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks four consecutive in-frame coding exons compared to variant 3. This results in a shorter isoform (1) missing a 1104 aa internal protein segment compared to isoform 3.
    Source sequence(s)
    AJ314765, AJ416458
    Consensus CDS
    CCDS14332.1
    UniProtKB/Swiss-Prot
    Q8WWL7
    Related
    ENSP00000338682.2, ENST00000348603.2
    Conserved Domains (2) summary
    pfam00134
    Location:71153
    Cyclin_N; Cyclin, N-terminal domain
    cl25647
    Location:71262
    Cyclin_N2; N-terminal region of cyclin_N

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    50202713..50351914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029915.1XP_016885404.1  G2/mitotic-specific cyclin-B3 isoform X1

    Conserved Domains (2) summary
    pfam00134
    Location:11331266
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:12681384
    Cyclin_C; Cyclin, C-terminal domain
  2. XM_017029914.1XP_016885403.1  G2/mitotic-specific cyclin-B3 isoform X1

    Conserved Domains (2) summary
    pfam00134
    Location:11331266
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:12681384
    Cyclin_C; Cyclin, C-terminal domain
  3. XM_017029913.1XP_016885402.1  G2/mitotic-specific cyclin-B3 isoform X1

    Conserved Domains (2) summary
    pfam00134
    Location:11331266
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:12681384
    Cyclin_C; Cyclin, C-terminal domain
  4. XM_017029917.1XP_016885406.1  G2/mitotic-specific cyclin-B3 isoform X3

    Conserved Domains (2) summary
    pfam00134
    Location:11331258
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:12601376
    Cyclin_C; Cyclin, C-terminal domain
  5. XM_017029916.1XP_016885405.1  G2/mitotic-specific cyclin-B3 isoform X2

  6. XM_017029918.1XP_016885407.1  G2/mitotic-specific cyclin-B3 isoform X4

    UniProtKB/Swiss-Prot
    Q8WWL7
    Related
    ENSP00000365210.1, ENST00000376042.5
    Conserved Domains (2) summary
    pfam00134
    Location:11321257
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:12591375
    Cyclin_C; Cyclin, C-terminal domain
  7. XM_024452472.1XP_024308240.1  G2/mitotic-specific cyclin-B3 isoform X1

    Conserved Domains (2) summary
    pfam00134
    Location:11331266
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:12681384
    Cyclin_C; Cyclin, C-terminal domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033671.1: Suppressed sequence

    Description
    NM_033671.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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