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DGKD diacylglycerol kinase delta [ Homo sapiens (human) ]

Gene ID: 8527, updated on 2-Nov-2024

Summary

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Official Symbol
DGKDprovided by HGNC
Official Full Name
diacylglycerol kinase deltaprovided by HGNC
Primary source
HGNC:HGNC:2851
See related
Ensembl:ENSG00000077044 MIM:601826; AllianceGenome:HGNC:2851
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dgkd-2; DGKdelta; DGK-delta
Summary
This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Broad expression in stomach (RPKM 11.9), bone marrow (RPKM 9.9) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See DGKD in Genome Data Viewer
Location:
2q37.1
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (233354494..233472098)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (233842577..233960616)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (234263140..234380744)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene autophagy related 16 like 1 Neighboring gene NANOG hESC enhancer GRCh37_chr2:234197330-234197831 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:234227861-234228828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:234228829-234229795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17338 Neighboring gene small Cajal body-specific RNA 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:234234987-234235964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:234237262-234238093 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:234238124-234238905 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17341 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17342 Neighboring gene MPRA-validated peak4087 silencer Neighboring gene S-antigen visual arrestin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17343 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17345 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:234307646-234308151 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17346 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17347 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:234334881-234336080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17349 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:234359341-234359904 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:234376565-234376780 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:234382503-234383102 Neighboring gene ubiquitin specific peptidase 40 Neighboring gene PPFIA1 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:234491694-234492284 Neighboring gene UDP glucuronosyltransferase family 1 member A12, pseudogene Neighboring gene UDP glucuronosyltransferase family 1 member A complex locus

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Analysis of the genotype of diacylglycerol kinase delta single-nucleotide polymorphisms in Parkinson disease in the Han Chinese population. Song W, et al. Neurol India, 2012 Jan-Feb. PMID 22406787
  2. Diacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domains. Nagaya H, et al. Mol Biol Cell, 2002 Jan. PMID 11809841, Free PMC Article
  3. Phorbol ester-regulated oligomerization of diacylglycerol kinase delta linked to its phosphorylation and translocation. Imai S, et al. J Biol Chem, 2002 Sep 20. PMID 12084710
  4. Zinc binding drives sheet formation by the SAM domain of diacylglycerol kinase δ. Knight MJ, et al. Biochemistry, 2010 Nov 9. PMID 20857926, Free PMC Article
  5. Expression, Purification, and Properties of a Human Arachidonoyl-Specific Isoform of Diacylglycerol Kinase. Jennings W, et al. Biochemistry, 2017 Mar 7. PMID 28199087

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Diacylglycerol kinase delta and sphingomyelin synthase-related protein functionally interact via their sterile alpha motif domains.
    Title: Diacylglycerol kinase δ and sphingomyelin synthase-related protein functionally interact via their sterile α motif domains.
  2. purification and characterization of DGKepsilon's enzymatic and conformational properties
    Title: Expression, Purification, and Properties of a Human Arachidonoyl-Specific Isoform of Diacylglycerol Kinase.
  3. Diacylglycerol signaling limits Akt activation through diacylglycerol kinase delta and PHLPP2.
    Title: Diacylglycerol kinase δ modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2).
  4. This study demonistrated that the lack of association of DGKD SNPs with PD in the Han Chinese population.
    Title: Analysis of the genotype of diacylglycerol kinase delta single-nucleotide polymorphisms in Parkinson disease in the Han Chinese population.
  5. Zinc site mutations impair DGKdelta localization to cytoplasmic puncta and enhance localization the plasma membrane.
    Title: Zinc binding drives sheet formation by the SAM domain of diacylglycerol kinase δ.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  7. Data indicate a novel mechanism where diacylglycerol kinase delta and protein kinase Calpha modulate the levels of ubiquitinated epidermal growth factor receptors through Akt and ubiquitin-specific protease 8.
    Title: Diacylglycerol kinase delta and protein kinase C(alpha) modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8.
  8. Polymerization of DGK delta regulates the activity of the enzyme by sequestering DGK delta in an inactive cellular location.
    Title: Regulation of enzyme localization by polymerization: polymer formation by the SAM domain of diacylglycerol kinase delta1.
  9. Study identified reduced diacylglycerol kinase delta (DGKdelta) expression and DGK activity in skeletal muscle from type 2 diabetic patients.
    Title: Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.
  10. Alternative splicing of the gene generates two isoforms differing in their expression patterns and in regulatory functions
    Title: Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
EBI GWAS Catalog
Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.
EBI GWAS Catalog
Genome-wide association of serum bilirubin levels in Korean population.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of diacylglycerol kinase, delta 130kDa (DGKD) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ26930, KIAA0145

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent diacylglycerol kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables diacylglycerol binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in diacylglycerol catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within diacylglycerol metabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in diacylglycerol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of phospholipase C/protein kinase C signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidic acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in platelet activation TAS
Traceable Author Statement
more info
  
involved_in positive regulation of clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of epidermal growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
diacylglycerol kinase delta
Names
DAG kinase delta
diacylglycerol kinase, delta 130kDa
diglyceride kinase delta
NP_001364188.1
NP_003639.2
NP_690618.2
XP_011510330.2
XP_011510331.2
XP_011510332.1
XP_011510333.1
XP_011510334.1
XP_011510335.2
XP_011510337.1
XP_011510341.2
XP_016860627.1
XP_047302053.1
XP_047302055.1
XP_047302056.1
XP_047302057.1
XP_047302058.1
XP_047302059.1
XP_054200226.1
XP_054200227.1
XP_054200228.1
XP_054200229.1
XP_054200230.1
XP_054200231.1
XP_054200232.1
XP_054200233.1
XP_054200234.1
XP_054200235.1
XP_054200236.1
XP_054200237.1
XP_054200238.1
XP_054200239.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029495.1 RefSeqGene

    Range
    4988..122592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001377259.1 → NP_001364188.1  diacylglycerol kinase delta isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC013726, AC019221
    UniProtKB/TrEMBL
    Q53SE4
    Conserved Domains (5) summary
    cd09575
    Location:1008 → 1072
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00045
    Location:630 → 787
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:190 → 312
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd20847
    Location:7 → 91
    C1_DGKdelta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins
    cd20893
    Location:98 → 158
    C1_DGKdelta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins

  2. NM_003648.3 → NP_003639.2  diacylglycerol kinase delta isoform 1

    See identical proteins and their annotated locations for NP_003639.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and uses a different in-frame start codon, compared to variant 2. The encoded isoform (1) has a shorter, distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    AC019221, BC006561, D63479, D73409
    Consensus CDS
    CCDS46546.1
    UniProtKB/TrEMBL
    Q53SE4
    Related
    ENSP00000386455.3, ENST00000409813.7
    Conserved Domains (7) summary
    cd09575
    Location:1097 → 1161
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00454
    Location:1098 → 1161
    SAM; Sterile alpha motif
    smart00045
    Location:719 → 876
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:279 → 401
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:120 → 169
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:11 → 107
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    pfam00169
    Location:10 → 98
    PH; PH domain

  3. NM_152879.3 → NP_690618.2  diacylglycerol kinase delta isoform 2

    See identical proteins and their annotated locations for NP_690618.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AC013726, AC019221, BC006561, D63479
    Consensus CDS
    CCDS2504.1
    UniProtKB/Swiss-Prot
    Q14158, Q16760, Q6PK55, Q8NG53
    UniProtKB/TrEMBL
    Q53SE4
    Related
    ENSP00000264057.2, ENST00000264057.7
    Conserved Domains (7) summary
    cd09575
    Location:1141 → 1205
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00454
    Location:1142 → 1205
    SAM; Sterile alpha motif
    smart00045
    Location:763 → 920
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:323 → 445
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:164 → 213
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:55 → 151
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    pfam00169
    Location:54 → 142
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    233354494..233472098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047446097.1 → XP_047302053.1  diacylglycerol kinase delta isoform X3

  2. XM_017005138.3 → XP_016860627.1  diacylglycerol kinase delta isoform X4

    UniProtKB/TrEMBL
    Q53SE4
    Conserved Domains (7) summary
    cd09575
    Location:1101 → 1165
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00454
    Location:1102 → 1165
    SAM; Sterile alpha motif
    smart00045
    Location:723 → 880
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:283 → 405
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:124 → 173
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:15 → 111
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    pfam00169
    Location:14 → 102
    PH; PH domain

  3. XM_011512028.4 → XP_011510330.2  diacylglycerol kinase delta isoform X1

  4. XM_011512029.4 → XP_011510331.2  diacylglycerol kinase delta isoform X2

  5. XM_011512033.4 → XP_011510335.2  diacylglycerol kinase delta isoform X7

  6. XM_011512039.3 → XP_011510341.2  diacylglycerol kinase delta isoform X9

  7. XM_047446101.1 → XP_047302057.1  diacylglycerol kinase delta isoform X10

  8. XM_011512031.4 → XP_011510333.1  diacylglycerol kinase delta isoform X6

    See identical proteins and their annotated locations for XP_011510333.1

    UniProtKB/TrEMBL
    Q53SE4
    Conserved Domains (7) summary
    cd09575
    Location:1083 → 1147
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00454
    Location:1084 → 1147
    SAM; Sterile alpha motif
    smart00045
    Location:705 → 862
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:265 → 387
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:106 → 155
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:1 → 93
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    pfam00169
    Location:1 → 84
    PH; PH domain

  9. XM_011512030.3 → XP_011510332.1  diacylglycerol kinase delta isoform X5

    UniProtKB/TrEMBL
    Q53SE4
    Conserved Domains (7) summary
    cd09575
    Location:1098 → 1162
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00454
    Location:1099 → 1162
    SAM; Sterile alpha motif
    smart00045
    Location:720 → 877
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:280 → 402
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:121 → 170
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:12 → 108
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    pfam00169
    Location:11 → 99
    PH; PH domain

  10. XM_011512032.4 → XP_011510334.1  diacylglycerol kinase delta isoform X6

    See identical proteins and their annotated locations for XP_011510334.1

    UniProtKB/TrEMBL
    Q53SE4
    Conserved Domains (7) summary
    cd09575
    Location:1083 → 1147
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00454
    Location:1084 → 1147
    SAM; Sterile alpha motif
    smart00045
    Location:705 → 862
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:265 → 387
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:106 → 155
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:1 → 93
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    pfam00169
    Location:1 → 84
    PH; PH domain

  11. XM_047446100.1 → XP_047302056.1  diacylglycerol kinase delta isoform X8

  12. XM_011512035.2 → XP_011510337.1  diacylglycerol kinase delta isoform X8

    See identical proteins and their annotated locations for XP_011510337.1

    UniProtKB/TrEMBL
    Q53SE4
    Conserved Domains (5) summary
    cd09575
    Location:1008 → 1072
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00045
    Location:630 → 787
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:190 → 312
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd20847
    Location:7 → 91
    C1_DGKdelta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins
    cd20893
    Location:98 → 158
    C1_DGKdelta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins

  13. XM_047446099.1 → XP_047302055.1  diacylglycerol kinase delta isoform X8

  14. XM_047446103.1 → XP_047302059.1  diacylglycerol kinase delta isoform X11

  15. XM_047446102.1 → XP_047302058.1  diacylglycerol kinase delta isoform X11

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_011332690.1 Reference GRCh38.p14 PATCHES

    Range
    299832..335841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    233842577..233960616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344253.1 → XP_054200228.1  diacylglycerol kinase delta isoform X3

  2. XM_054344254.1 → XP_054200229.1  diacylglycerol kinase delta isoform X4

  3. XM_054344262.1 → XP_054200237.1  diacylglycerol kinase delta isoform X16

  4. XM_054344258.1 → XP_054200233.1  diacylglycerol kinase delta isoform X14

  5. XM_054344251.1 → XP_054200226.1  diacylglycerol kinase delta isoform X12

  6. XM_054344252.1 → XP_054200227.1  diacylglycerol kinase delta isoform X13

  7. XM_054344260.1 → XP_054200235.1  diacylglycerol kinase delta isoform X15

  8. XM_054344257.1 → XP_054200232.1  diacylglycerol kinase delta isoform X6

  9. XM_054344256.1 → XP_054200231.1  diacylglycerol kinase delta isoform X6

  10. XM_054344255.1 → XP_054200230.1  diacylglycerol kinase delta isoform X5

  11. XM_054344261.1 → XP_054200236.1  diacylglycerol kinase delta isoform X8

  12. XM_054344259.1 → XP_054200234.1  diacylglycerol kinase delta isoform X8

  13. XM_054344264.1 → XP_054200239.1  diacylglycerol kinase delta isoform X11

  14. XM_054344263.1 → XP_054200238.1  diacylglycerol kinase delta isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16760.4 GenPept UniProtKB/Swiss-Prot:Q16760

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