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DGKD diacylglycerol kinase delta [ Homo sapiens (human) ]

Gene ID: 8527, updated on 8-Dec-2018

Summary

Official Symbol
DGKDprovided by HGNC
Official Full Name
diacylglycerol kinase deltaprovided by HGNC
Primary source
HGNC:HGNC:2851
See related
Ensembl:ENSG00000077044 MIM:601826
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dgkd-2; DGKdelta
Summary
This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Broad expression in stomach (RPKM 11.9), bone marrow (RPKM 9.9) and 23 other tissues See more
Orthologs

Genomic context

See DGKD in Genome Data Viewer
Location:
2q37.1
Exon count:
40
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (233354507..233472098)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (234263149..234380744)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene autophagy related 16 like 1 Neighboring gene small Cajal body-specific RNA 6 Neighboring gene S-antigen visual arrestin Neighboring gene ubiquitin specific peptidase 40 Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 pseudogene Neighboring gene UDP glucuronosyltransferase family 1 member A12, pseudogene Neighboring gene UDP glucuronosyltransferase family 1 member A complex locus

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
NHGRI GWA Catalog
Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.
NHGRI GWA Catalog
Genome-wide association of serum bilirubin levels in Korean population.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of diacylglycerol kinase, delta 130kDa (DGKD) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26930, KIAA0145

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NAD+ kinase activity IEA
Inferred from Electronic Annotation
more info
 
diacylglycerol binding NAS
Non-traceable Author Statement
more info
PubMed 
diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
diacylglycerol kinase activity TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diacylglycerol metabolic process IC
Inferred by Curator
more info
PubMed 
diacylglycerol metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
glycerolipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid phosphorylation TAS
Traceable Author Statement
more info
PubMed 
multicellular organism development NAS
Non-traceable Author Statement
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase C-activating G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
second-messenger-mediated signaling NAS
Non-traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
diacylglycerol kinase delta
Names
DAG kinase delta
DGK-delta
diacylglycerol kinase, delta 130kDa
diglyceride kinase delta
NP_003639.2
NP_690618.2
XP_005246164.1
XP_005246165.1
XP_011510330.1
XP_011510331.1
XP_011510332.1
XP_011510333.1
XP_011510334.1
XP_011510335.1
XP_011510337.1
XP_011510341.1
XP_016860627.1
XP_016860628.1
XP_016860629.1
XP_024308957.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029495.1 RefSeqGene

    Range
    5001..122591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003648.2NP_003639.2  diacylglycerol kinase delta isoform 1

    See identical proteins and their annotated locations for NP_003639.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and uses a different in-frame start codon, compared to variant 2. The encoded isoform (1) has a shorter, distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    BC006561, D63479, D73409
    Consensus CDS
    CCDS46546.1
    UniProtKB/Swiss-Prot
    Q16760
    UniProtKB/TrEMBL
    A0A024R495
    Related
    ENSP00000386455.3, ENST00000409813.7
    Conserved Domains (7) summary
    cd09575
    Location:10971161
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00454
    Location:10981161
    SAM; Sterile alpha motif
    smart00045
    Location:719876
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:279401
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:120169
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:11107
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    pfam00169
    Location:1098
    PH; PH domain
  2. NM_152879.2NP_690618.2  diacylglycerol kinase delta isoform 2

    See identical proteins and their annotated locations for NP_690618.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AC013726, BC006561, D63479
    Consensus CDS
    CCDS2504.1
    UniProtKB/Swiss-Prot
    Q16760
    Related
    ENSP00000264057.2, ENST00000264057.6
    Conserved Domains (7) summary
    cd09575
    Location:11411205
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00454
    Location:11421205
    SAM; Sterile alpha motif
    smart00045
    Location:763920
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:323445
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:164213
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:55151
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    pfam00169
    Location:54142
    PH; PH domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    233354507..233472098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005138.2XP_016860627.1  diacylglycerol kinase delta isoform X3

    Conserved Domains (7) summary
    cd09575
    Location:11011165
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00454
    Location:11021165
    SAM; Sterile alpha motif
    smart00045
    Location:723880
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:283405
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:124173
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:15111
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    pfam00169
    Location:14102
    PH; PH domain
  2. XM_011512033.3XP_011510335.1  diacylglycerol kinase delta isoform X7

    Conserved Domains (5) summary
    smart00045
    Location:787944
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:347469
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:188237
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:79175
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    pfam00169
    Location:78166
    PH; PH domain
  3. XM_011512029.3XP_011510331.1  diacylglycerol kinase delta isoform X2

    Conserved Domains (5) summary
    smart00045
    Location:787944
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:347469
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:188237
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:79175
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    pfam00169
    Location:78166
    PH; PH domain
  4. XM_011512039.2XP_011510341.1  diacylglycerol kinase delta isoform X10

    Conserved Domains (5) summary
    smart00045
    Location:787944
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:347469
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:188237
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:79175
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    pfam00169
    Location:78166
    PH; PH domain
  5. XM_011512028.3XP_011510330.1  diacylglycerol kinase delta isoform X1

    Conserved Domains (7) summary
    cd09575
    Location:11651229
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00454
    Location:11661229
    SAM; Sterile alpha motif
    smart00045
    Location:787944
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:347469
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:188237
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:79175
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    pfam00169
    Location:78166
    PH; PH domain
  6. XM_011512031.3XP_011510333.1  diacylglycerol kinase delta isoform X5

    See identical proteins and their annotated locations for XP_011510333.1

    Conserved Domains (7) summary
    cd09575
    Location:10831147
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00454
    Location:10841147
    SAM; Sterile alpha motif
    smart00045
    Location:705862
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:265387
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:106155
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:193
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    pfam00169
    Location:184
    PH; PH domain
  7. XM_011512032.3XP_011510334.1  diacylglycerol kinase delta isoform X5

    See identical proteins and their annotated locations for XP_011510334.1

    Conserved Domains (7) summary
    cd09575
    Location:10831147
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00454
    Location:10841147
    SAM; Sterile alpha motif
    smart00045
    Location:705862
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:265387
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:106155
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:193
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    pfam00169
    Location:184
    PH; PH domain
  8. XM_011512030.2XP_011510332.1  diacylglycerol kinase delta isoform X4

    Conserved Domains (7) summary
    cd09575
    Location:10981162
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00454
    Location:10991162
    SAM; Sterile alpha motif
    smart00045
    Location:720877
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:280402
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:121170
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:12108
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    pfam00169
    Location:1199
    PH; PH domain
  9. XM_017005140.1XP_016860629.1  diacylglycerol kinase delta isoform X9

    Conserved Domains (6) summary
    cd09575
    Location:10081072
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00454
    Location:10091072
    SAM; Sterile alpha motif
    smart00045
    Location:630787
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:190312
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:3180
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl17171
    Location:118
    PH-like; Pleckstrin homology-like domain
  10. XM_024453189.1XP_024308957.1  diacylglycerol kinase delta isoform X11

    Conserved Domains (2) summary
    cd09575
    Location:700764
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00045
    Location:322479
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
  11. XM_011512035.1XP_011510337.1  diacylglycerol kinase delta isoform X9

    See identical proteins and their annotated locations for XP_011510337.1

    Conserved Domains (6) summary
    cd09575
    Location:10081072
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00454
    Location:10091072
    SAM; Sterile alpha motif
    smart00045
    Location:630787
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:190312
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:3180
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl17171
    Location:118
    PH-like; Pleckstrin homology-like domain
  12. XM_017005139.1XP_016860628.1  diacylglycerol kinase delta isoform X6

  13. XM_005246108.1XP_005246165.1  diacylglycerol kinase delta isoform X9

    See identical proteins and their annotated locations for XP_005246165.1

    Conserved Domains (6) summary
    cd09575
    Location:10081072
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00454
    Location:10091072
    SAM; Sterile alpha motif
    smart00045
    Location:630787
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:190312
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:3180
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl17171
    Location:118
    PH-like; Pleckstrin homology-like domain
  14. XM_005246107.3XP_005246164.1  diacylglycerol kinase delta isoform X8

    Conserved Domains (6) summary
    cd09575
    Location:10291093
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00454
    Location:10301093
    SAM; Sterile alpha motif
    smart00045
    Location:651808
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:211333
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:52101
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl17171
    Location:539
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_923050.2 RNA Sequence

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_011332690.1 Reference GRCh38.p12 PATCHES

    Range
    299845..335841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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