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Dgkd diacylglycerol kinase, delta [ Mus musculus (house mouse) ]

Gene ID: 227333, updated on 8-Feb-2024

Summary

Official Symbol
Dgkdprovided by MGI
Official Full Name
diacylglycerol kinase, deltaprovided by MGI
Primary source
MGI:MGI:2138334
See related
Ensembl:ENSMUSG00000070738 AllianceGenome:MGI:2138334
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
dgkd-2; DGKdelta; D330025K09
Summary
Enables diacylglycerol kinase activity. Involved in diacylglycerol metabolic process; lipid phosphorylation; and regulation of signal transduction. Predicted to be located in clathrin-coated pit; cytoplasmic vesicle; and cytosol. Is expressed in several structures, including brain; immune system; musculature; reproductive system; and stomach. Used to study Lennox-Gastaut syndrome. Orthologous to human DGKD (diacylglycerol kinase delta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 36.4), spleen adult (RPKM 18.4) and 28 other tissues See more
Orthologs
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Genomic context

See Dgkd in Genome Data Viewer
Location:
1 D; 1 44.44 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (87780942..87872900)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (87853264..87945177)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene autophagy related 16 like 1 Neighboring gene predicted gene, 53572 Neighboring gene small Cajal body-specific RNA 6 Neighboring gene STARR-seq mESC enhancer starr_01624 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:89724892-89725168 Neighboring gene S-antigen, retina and pineal gland (arrestin) Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:89743594-89743830 Neighboring gene STARR-positive B cell enhancer ABC_E10019 Neighboring gene STARR-positive B cell enhancer mm9_chr1:89763253-89763553 Neighboring gene predicted gene, 19582 Neighboring gene STARR-seq mESC enhancer starr_01625 Neighboring gene ubiquitin specific peptidase 40 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 pseudogene Neighboring gene karyopherin (importin) alpha 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0145

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP-dependent diacylglycerol kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ATP-dependent diacylglycerol kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in diacylglycerol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within diacylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipid phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein kinase C signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
diacylglycerol kinase delta
Names
DAG kinase delta
NP_808314.2
XP_006529534.1
XP_006529535.1
XP_011246290.1
XP_017175841.1
XP_030109593.1
XP_036020405.1
XP_036020407.1
XP_036020416.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177646.3NP_808314.2  diacylglycerol kinase delta

    Status: VALIDATED

    Source sequence(s)
    AC102630, AC162281
    Consensus CDS
    CCDS48312.1
    UniProtKB/Swiss-Prot
    E9PUQ8
    UniProtKB/TrEMBL
    Q6A0B7
    Related
    ENSMUSP00000027517.8, ENSMUST00000027517.14
    Conserved Domains (6) summary
    cd09575
    Location:11471211
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00045
    Location:765922
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:323445
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd13274
    Location:55151
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    cd20847
    Location:140224
    C1_DGKdelta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins
    cd20893
    Location:231291
    C1_DGKdelta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    87780942..87872900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529472.5XP_006529535.1  diacylglycerol kinase delta isoform X2

    UniProtKB/TrEMBL
    Q6A0B7
    Conserved Domains (4) summary
    smart00045
    Location:765922
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:323445
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:164213
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:55151
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
  2. XM_036164514.1XP_036020407.1  diacylglycerol kinase delta isoform X4

    UniProtKB/TrEMBL
    Q6A0B7
    Conserved Domains (6) summary
    cd09575
    Location:11091173
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00046
    Location:323445
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd13274
    Location:55151
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    cd20847
    Location:140224
    C1_DGKdelta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins
    cd20893
    Location:231291
    C1_DGKdelta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins
    cl02440
    Location:765884
    DAGK_acc; Diacylglycerol kinase accessory domain
  3. XM_006529471.4XP_006529534.1  diacylglycerol kinase delta isoform X1

    UniProtKB/TrEMBL
    Q6A0B7
    Conserved Domains (5) summary
    smart00045
    Location:765922
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:323445
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:164213
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:55151
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    cl15755
    Location:11471193
    SAM_superfamily; SAM (Sterile alpha motif )
  4. XM_036164512.1XP_036020405.1  diacylglycerol kinase delta isoform X3

    UniProtKB/TrEMBL
    Q6A0B7
    Conserved Domains (6) summary
    smart00046
    Location:323445
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd13274
    Location:55151
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    cd20847
    Location:140224
    C1_DGKdelta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins
    cd20893
    Location:231291
    C1_DGKdelta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins
    cl02440
    Location:765884
    DAGK_acc; Diacylglycerol kinase accessory domain
    cl15755
    Location:11091155
    SAM_superfamily; SAM (Sterile alpha motif )
  5. XM_030253733.2XP_030109593.1  diacylglycerol kinase delta isoform X5

    UniProtKB/TrEMBL
    Q6A0B7
    Conserved Domains (5) summary
    smart00045
    Location:632789
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:190312
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:3180
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl15755
    Location:10141060
    SAM_superfamily; SAM (Sterile alpha motif )
    cl17171
    Location:118
    PH-like; Pleckstrin homology-like domain
  6. XM_036164523.1XP_036020416.1  diacylglycerol kinase delta isoform X6

    UniProtKB/TrEMBL
    Q6A0B7
    Conserved Domains (5) summary
    cd09575
    Location:10141078
    SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
    smart00045
    Location:632789
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:190312
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd20847
    Location:791
    C1_DGKdelta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins
    cd20893
    Location:98158
    C1_DGKdelta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins
  7. XM_011247988.4XP_011246290.1  diacylglycerol kinase delta isoform X5

    See identical proteins and their annotated locations for XP_011246290.1

    UniProtKB/TrEMBL
    Q6A0B7
    Conserved Domains (5) summary
    smart00045
    Location:632789
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:190312
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:3180
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl15755
    Location:10141060
    SAM_superfamily; SAM (Sterile alpha motif )
    cl17171
    Location:118
    PH-like; Pleckstrin homology-like domain
  8. XM_017320352.3XP_017175841.1  diacylglycerol kinase delta isoform X5

    UniProtKB/TrEMBL
    Q6A0B7
    Conserved Domains (5) summary
    smart00045
    Location:632789
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:190312
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:3180
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl15755
    Location:10141060
    SAM_superfamily; SAM (Sterile alpha motif )
    cl17171
    Location:118
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_003955002.2 RNA Sequence