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DGKE diacylglycerol kinase epsilon [ Homo sapiens (human) ]

Gene ID: 8526, updated on 10-Oct-2019

Summary

Official Symbol
DGKEprovided by HGNC
Official Full Name
diacylglycerol kinase epsilonprovided by HGNC
Primary source
HGNC:HGNC:2852
See related
Ensembl:ENSG00000153933 MIM:601440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DGK; AHUS7; DAGK5; DAGK6; NPHS7
Summary
Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 3.8), spleen (RPKM 3.2) and 25 other tissues See more
Orthologs

Genomic context

See DGKE in Genome Data Viewer
Location:
17q22
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (56834131..56869567)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (54911460..54946036)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene noggin Neighboring gene chromosome 17 open reading frame 67 Neighboring gene RNA, U6 small nuclear 1158, pseudogene Neighboring gene mouse mammary tumor virus receptor homolog 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NAD+ kinase activity IEA
Inferred from Electronic Annotation
more info
 
diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerolipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
phospholipid biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
protein kinase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
diacylglycerol kinase epsilon
Names
DAG kinase epsilon
DGK-epsilon
diacylglycerol kinase, epsilon 64kDa
diglyceride kinase epsilon
NP_003638.1
XP_011523696.1
XP_011523697.1
XP_011523698.1
XP_016880732.1
XP_016880733.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033888.1 RefSeqGene

    Range
    5053..40469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003647.3NP_003638.1  diacylglycerol kinase epsilon

    See identical proteins and their annotated locations for NP_003638.1

    Status: REVIEWED

    Source sequence(s)
    AC015912, AL555194, BC130629, BM682264, DB221284
    Consensus CDS
    CCDS11590.1
    UniProtKB/Swiss-Prot
    P52429
    UniProtKB/TrEMBL
    A1L4Q0
    Related
    ENSP00000284061.3, ENST00000284061.8
    Conserved Domains (4) summary
    smart00109
    Location:125174
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00045
    Location:369524
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:221349
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    pfam00130
    Location:60109
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    56834131..56869567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025243.2XP_016880732.1  diacylglycerol kinase epsilon isoform X1

  2. XM_011525396.2XP_011523698.1  diacylglycerol kinase epsilon isoform X5

    Conserved Domains (4) summary
    smart00109
    Location:143192
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00046
    Location:239367
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    pfam00130
    Location:78127
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02440
    Location:387446
    DAGK_acc; Diacylglycerol kinase accessory domain
  3. XM_011525395.2XP_011523697.1  diacylglycerol kinase epsilon isoform X4

    Related
    ENSP00000458493.1, ENST00000572944.1
    Conserved Domains (4) summary
    smart00109
    Location:143192
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00046
    Location:239367
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    pfam00130
    Location:78127
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02440
    Location:387526
    DAGK_acc; Diacylglycerol kinase accessory domain
  4. XM_017025244.2XP_016880733.1  diacylglycerol kinase epsilon isoform X3

  5. XM_011525394.3XP_011523696.1  diacylglycerol kinase epsilon isoform X2

    Conserved Domains (4) summary
    smart00109
    Location:143192
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00045
    Location:387542
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:239367
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    pfam00130
    Location:78127
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RNA

  1. XR_001752670.2 RNA Sequence

  2. XR_001752672.1 RNA Sequence

  3. XR_001752671.1 RNA Sequence

  4. XR_002958079.1 RNA Sequence

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