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HAT1 histone acetyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 8520, updated on 21-Dec-2019

Summary

Official Symbol
HAT1provided by HGNC
Official Full Name
histone acetyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:4821
See related
Ensembl:ENSG00000128708 MIM:603053
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAT1
Summary
The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]
Expression
Ubiquitous expression in lymph node (RPKM 13.0), bone marrow (RPKM 11.6) and 25 other tissues See more
Orthologs

Genomic context

See HAT1 in Genome Data Viewer
Location:
2q31.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (171922425..171983686)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (172778935..172848600)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373739 Neighboring gene uncharacterized LOC105373740 Neighboring gene VISTA enhancer hs646 Neighboring gene PDGFA associated protein 1 pseudogene Neighboring gene methionyl aminopeptidase type 1D, mitochondrial Neighboring gene VISTA enhancer hs553 Neighboring gene distal-less homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed
Vpr vpr HIV-1 Vpr forms a complex by recruiting RbAp46, HAT1, ZIP/sZIP, and Cul4A PubMed
vpr HIV-1 Vpr is identified to have a physical interaction with histone acetyltransferase 1 (HAT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
H4 histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
H4 histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA packaging TAS
Traceable Author Statement
more info
PubMed 
DNA replication-dependent nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
DNA replication-independent nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
chromatin silencing at telomere IEA
Inferred from Electronic Annotation
more info
 
histone H4 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H4 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
internal protein amino acid acetylation TAS
Traceable Author Statement
more info
PubMed 
response to nutrient IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromosome, telomeric region HDA PubMed 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone acetyltransferase type B catalytic subunit
NP_003633.2
XP_006712871.1
XP_016860625.1
XP_016860626.1
XP_024308954.1
XP_024308955.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003642.4NP_003633.2  histone acetyltransferase type B catalytic subunit

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AC114745
    Consensus CDS
    CCDS2245.1
    Related
    ENSP00000264108.4, ENST00000264108.5
    Conserved Domains (1) summary
    pfam10394
    Location:25187
    Hat1_N; Histone acetyl transferase HAT1 N-terminus

RNA

  1. NR_027862.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC063003, DB050336
    Related
    ENST00000412731.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    171922425..171983686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712808.3XP_006712871.1  histone acetyltransferase type B catalytic subunit isoform X1

    See identical proteins and their annotated locations for XP_006712871.1

    Conserved Domains (1) summary
    pfam10394
    Location:19181
    Hat1_N; Histone acetyl transferase HAT1 N-terminus
  2. XM_024453187.1XP_024308955.1  histone acetyltransferase type B catalytic subunit isoform X1

    Conserved Domains (1) summary
    pfam10394
    Location:19181
    Hat1_N; Histone acetyl transferase HAT1 N-terminus
  3. XM_024453186.1XP_024308954.1  histone acetyltransferase type B catalytic subunit isoform X1

    Conserved Domains (1) summary
    pfam10394
    Location:19181
    Hat1_N; Histone acetyl transferase HAT1 N-terminus
  4. XM_017005136.2XP_016860625.1  histone acetyltransferase type B catalytic subunit isoform X1

    Conserved Domains (1) summary
    pfam10394
    Location:19181
    Hat1_N; Histone acetyl transferase HAT1 N-terminus
  5. XM_017005137.2XP_016860626.1  histone acetyltransferase type B catalytic subunit isoform X1

    Conserved Domains (1) summary
    pfam10394
    Location:19181
    Hat1_N; Histone acetyl transferase HAT1 N-terminus

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033085.1: Suppressed sequence

    Description
    NM_001033085.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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