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Hat1 histone aminotransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 107435, updated on 5-Mar-2024

Summary

Official Symbol
Hat1provided by MGI
Official Full Name
histone aminotransferase 1provided by MGI
Primary source
MGI:MGI:96013
See related
Ensembl:ENSMUSG00000027018 AllianceGenome:MGI:96013
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KAT1; Hat-1; 2410071B14Rik
Summary
Predicted to enable H4 histone acetyltransferase activity. Predicted to be involved in DNA replication-dependent chromatin assembly; DNA replication-independent chromatin assembly; and histone H4 acetylation. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of protein-containing complex. Is expressed in several structures, including brain; liver; optic nerve; testis; and thymus primordium. Orthologous to human HAT1 (histone acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 51.2), placenta adult (RPKM 46.5) and 16 other tissues See more
Orthologs
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Genomic context

See Hat1 in Genome Data Viewer
Location:
2 C2; 2 42.38 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (71219604..71271966)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (71389260..71441622)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04777 Neighboring gene dynein cytoplasmic 1 intermediate chain 2 Neighboring gene solute carrier family 25 (mitochondrial carrier, Aralar), member 12 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:71198352-71198535 Neighboring gene STARR-seq mESC enhancer starr_04786 Neighboring gene STARR-seq mESC enhancer starr_04790 Neighboring gene VISTA enhancer mm55 Neighboring gene nuclear protein-NHP2-like protein pseudogene Neighboring gene methionyl aminopeptidase type 1D (mitochondrial) Neighboring gene STARR-seq mESC enhancer starr_04791 Neighboring gene STARR-seq mESC enhancer starr_04792 Neighboring gene distal-less homeobox 1, antisense Neighboring gene distal-less homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone H4K12 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in subtelomeric heterochromatin formation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone acetyltransferase type B catalytic subunit
Names
histidine aminotransferase 1
histone acetyltransferase 1
NP_080391.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026115.4NP_080391.2  histone acetyltransferase type B catalytic subunit

    See identical proteins and their annotated locations for NP_080391.2

    Status: PROVISIONAL

    Source sequence(s)
    AK041700
    Consensus CDS
    CCDS16114.1
    UniProtKB/Swiss-Prot
    Q8BY71
    UniProtKB/TrEMBL
    A2ATU9
    Related
    ENSMUSP00000028408.3, ENSMUST00000028408.3
    Conserved Domains (3) summary
    pfam10394
    Location:22184
    Hat1_N; Histone acetyl transferase HAT1 N-terminus
    pfam13673
    Location:181285
    Acetyltransf_10; Acetyltransferase (GNAT) domain
    cl05000
    Location:323408
    CHASE3; CHASE3 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    71219604..71271966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)