Format

Send to:

Choose Destination

PIK3R3 phosphoinositide-3-kinase regulatory subunit 3 [ Homo sapiens (human) ]

Gene ID: 8503, updated on 1-Jun-2020

Summary

Official Symbol
PIK3R3provided by HGNC
Official Full Name
phosphoinositide-3-kinase regulatory subunit 3provided by HGNC
Primary source
HGNC:HGNC:8981
See related
Ensembl:ENSG00000117461 MIM:606076
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p55; p55PIK; p55-GAMMA
Summary
Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016]
Expression
Broad expression in testis (RPKM 19.6), fat (RPKM 8.4) and 20 other tissues See more
Orthologs

Genomic context

See PIK3R3 in Genome Data Viewer
Location:
1p34.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (46040140..46174901, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46505812..46642167, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microtubule associated serine/threonine kinase 2 Neighboring gene uncharacterized LOC105378694 Neighboring gene translation machinery associated 16 homolog pseudogene 2 Neighboring gene P3R3URF-PIK3R3 readthrough Neighboring gene uncharacterized LOC101929626 Neighboring gene PIK3R3 upstream reading frame Neighboring gene tetraspanin 1 Neighboring gene protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) Neighboring gene leucine rich adaptor protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough P3R3URF-PIK3R3

Readthrough gene: P3R3URF-PIK3R3, Included gene: P3R3URF

Homology

Clone Names

  • FLJ41892, DKFZp686P05226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol-3-kinase activity TAS
Traceable Author Statement
more info
PubMed 
1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell migration involved in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylinositol phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of phosphatidylinositol 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phosphatidylinositol 3-kinase regulatory subunit gamma
Names
PI3-kinase regulatory subunit gamma
PI3-kinase subunit p55-gamma
PI3K regulatory subunit gamma
phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma)
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
ptdIns-3-kinase regulatory subunit p55-gamma

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050949.1 RefSeqGene

    Range
    48701..141356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001114172.1NP_001107644.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_001107644.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK313726, BC021622, U90907
    Consensus CDS
    CCDS529.1
    UniProtKB/Swiss-Prot
    Q92569
    UniProtKB/TrEMBL
    Q8N381
    Related
    ENSP00000412546.1, ENST00000420542.5
    Conserved Domains (4) summary
    cd09930
    Location:351454
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:59167
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    pfam16454
    Location:171330
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
    cl23765
    Location:172332
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  2. NM_001303428.1NP_001290357.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon and uses an alternate splice site in the 5' coding region. These differences cause translation initiation at an upstream start codon compared to variant 1. The encoded isoform (3) has a longer N-terminus than isoform 1.
    Source sequence(s)
    AK302049, BX537388, CR749649
    UniProtKB/TrEMBL
    B4DXM8, Q68CY7, Q7Z3W2
    Conserved Domains (4) summary
    cd09930
    Location:368471
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:76184
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12925
    Location:189349
    iSH2_PIK3R3; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 3, PIK3R3, also called p55gamma
    pfam16454
    Location:188347
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
  3. NM_001303429.2NP_001290358.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 4

    See identical proteins and their annotated locations for NP_001290358.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AF028785, BC021622, BX507484, BX537388, CR749649
    Consensus CDS
    CCDS76154.1
    UniProtKB/Swiss-Prot
    Q92569
    UniProtKB/TrEMBL
    Q68CY7, Q7Z3W2, Q8N381
    Related
    ENSP00000391431.1, ENST00000423209.5
    Conserved Domains (3) summary
    cd09930
    Location:292395
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:59167
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:172273
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  4. NM_001328648.1NP_001315577.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1. Variants 6, 7, 8, and 9 all encode the same isoform (5).
    Source sequence(s)
    AL358075, AL672043
  5. NM_001328649.1NP_001315578.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1. Variants 6, 7, 8, and 9 all encode the same isoform (5).
    Source sequence(s)
    AL358075
  6. NM_001328650.1NP_001315579.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1. Variants 6, 7, 8, and 9 all encode the same isoform (5).
    Source sequence(s)
    AL358075
  7. NM_001328651.1NP_001315580.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1. Variants 6, 7, 8, and 9 all encode the same isoform (5).
    Source sequence(s)
    AL358075
  8. NM_001328652.2NP_001315581.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks an alternate in-frame exon in the 3' end compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL358075
  9. NM_001328653.2NP_001315582.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks an alternate exon in the 5' end and uses a downstream start codon compared to variant 1. The resulting isoform (7) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL358075
  10. NM_001328654.2NP_001315583.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) lacks two alternate exons in the 5' end and uses a downstream start codon compared to variant 1. The resulting isoform (8) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL358075
  11. NM_003629.4NP_003620.3  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_003620.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC021622, BC094768, U90907
    Consensus CDS
    CCDS529.1
    UniProtKB/Swiss-Prot
    Q92569
    UniProtKB/TrEMBL
    Q8N381
    Related
    ENSP00000262741.5, ENST00000262741.10
    Conserved Domains (4) summary
    cd09930
    Location:351454
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:59167
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    pfam16454
    Location:171330
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
    cl23765
    Location:172332
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RNA

  1. NR_137329.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL358075

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    46040140..46174901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center