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P3R3URF-PIK3R3 P3R3URF-PIK3R3 readthrough [ Homo sapiens (human) ]

Gene ID: 110117499, updated on 13-May-2022

Summary

Official Symbol
P3R3URF-PIK3R3provided by HGNC
Official Full Name
P3R3URF-PIK3R3 readthroughprovided by HGNC
Primary source
HGNC:HGNC:54999
See related
Ensembl:ENSG00000278139 AllianceGenome:HGNC:54999
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LOC110117498-PIK3R3
Summary
This locus represents naturally occurring readthrough transcription between the neighboring genes LOC110117498 and PIK3R3. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Apr 2017]
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Genomic context

See P3R3URF-PIK3R3 in Genome Data Viewer
Location:
1p34.1
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (46040140..46176488, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (45917331..46053683, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46505812..46642160, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microtubule associated serine/threonine kinase 2 Neighboring gene Sharpr-MPRA regulatory region 10352 Neighboring gene uncharacterized LOC105378694 Neighboring gene Sharpr-MPRA regulatory region 5403 Neighboring gene uncharacterized LOC124904171 Neighboring gene phosphoinositide-3-kinase regulatory subunit 3 Neighboring gene uncharacterized LOC101929626 Neighboring gene PIK3R3 upstream open reading frame Neighboring gene tetraspanin 1 Neighboring gene protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) Neighboring gene leucine rich adaptor protein 1 Neighboring gene RAD54 like Neighboring gene leucine rich repeat containing 41

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General protein information

Preferred Names
LOC110117498-PIK3R3 readthrough

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303427.2NP_001290356.1  LOC110117498-PIK3R3 readthrough

    Status: REVIEWED

    Source sequence(s)
    AK302049, BX537388, CR749649
    UniProtKB/TrEMBL
    B4DXM8, F6TDL0, Q68CY7, Q7Z3W2
    Related
    ENSP00000439913.1, ENST00000540385.2
    Conserved Domains (4) summary
    cd09930
    Location:397500
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:105213
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12925
    Location:218378
    iSH2_PIK3R3; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 3, PIK3R3, also called p55gamma
    pfam16454
    Location:217376
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    46040140..46176488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    45917331..46053683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)