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Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 18710, updated on 3-Apr-2024

Summary

Official Symbol
Pik3r3provided by MGI
Official Full Name
phosphoinositide-3-kinase regulatory subunit 3provided by MGI
Primary source
MGI:MGI:109277
See related
Ensembl:ENSMUSG00000028698 Ensembl:ENSMUSG00000111410 AllianceGenome:MGI:109277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p55; p55pik
Summary
Enables 1-phosphatidylinositol-3-kinase regulator activity. Acts upstream of or within insulin receptor signaling pathway. Part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 19.3), CNS E14 (RPKM 19.1) and 19 other tissues See more
Orthologs
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Genomic context

See Pik3r3 in Genome Data Viewer
Location:
4 D1; 4 53.1 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116078593..116160253)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116221400..116303056)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:115849369-115849478 Neighboring gene Pik3r3 upstream reading frame Neighboring gene STARR-seq mESC enhancer starr_11134 Neighboring gene STARR-seq mESC enhancer starr_11135 Neighboring gene LLP homolog, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E838 Neighboring gene STARR-seq mESC enhancer starr_11136 Neighboring gene BRCA1 associated RING domain 1 pseudogene Neighboring gene microtubule associated serine/threonine kinase 2 Neighboring gene STARR-seq mESC enhancer starr_11138 Neighboring gene predicted gene, 52760 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:116180277-116180386 Neighboring gene IAP promoted placental gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 1-phosphatidylinositol-3-kinase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 1-phosphatidylinositol-3-kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of phosphatidylinositol 3-kinase complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
phosphatidylinositol 3-kinase regulatory subunit gamma
Names
PI3-kinase regulatory subunit gamma
PI3-kinase subunit p55-gamma
PI3K regulatory subunit gamma
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
ptdIns-3-kinase regulatory subunit gamma
ptdIns-3-kinase regulatory subunit p55-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355584.2NP_001342513.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL670603
    Consensus CDS
    CCDS18509.1
    UniProtKB/Swiss-Prot
    Q64143
    UniProtKB/TrEMBL
    Q3TST3, Q3UXE9
    Conserved Domains (3) summary
    cd09930
    Location:351454
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:59167
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:172332
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  2. NM_001355585.1NP_001342514.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL670603, AW457297, BU612070, CA318834, CD350355, CN455231, CN525195, CN528038, CN535899, CV558350, CV562336
    Consensus CDS
    CCDS18509.1
    UniProtKB/Swiss-Prot
    Q64143
    UniProtKB/TrEMBL
    Q3TST3, Q3UXE9
    Conserved Domains (3) summary
    cd09930
    Location:351454
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:59167
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:172332
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  3. NM_001355586.1NP_001342515.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL670603, AW457297, BU612070, CA318834, CD350355, CN455231, CN525195, CN528038, CV558350, CV562336
    UniProtKB/TrEMBL
    Q3TST3
    Related
    ENSMUSP00000150163.2, ENSMUST00000216692.2
    Conserved Domains (3) summary
    cd09930
    Location:307410
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:15123
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:128288
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  4. NM_001421303.1NP_001408232.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL670603
  5. NM_001421304.1NP_001408233.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL670603
  6. NM_001421305.1NP_001408234.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL670603
  7. NM_001421306.1NP_001408235.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL670603
  8. NM_181585.7NP_853616.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_853616.1

    Status: VALIDATED

    Source sequence(s)
    AL670603
    Consensus CDS
    CCDS18509.1
    UniProtKB/Swiss-Prot
    Q64143
    UniProtKB/TrEMBL
    Q3TST3, Q3UXE9
    Related
    ENSMUSP00000030464.8, ENSMUST00000030464.14
    Conserved Domains (3) summary
    cd09930
    Location:351454
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:59167
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:172332
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    116078593..116160253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502860.5XP_006502923.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

    See identical proteins and their annotated locations for XP_006502923.1

    UniProtKB/TrEMBL
    Q3TST3
    Conserved Domains (3) summary
    cd09942
    Location:59167
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:172332
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    cl15255
    Location:351396
    SH2; Src homology 2 (SH2) domain
  2. XM_006502859.4XP_006502922.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

    See identical proteins and their annotated locations for XP_006502922.1

    UniProtKB/TrEMBL
    Q3TST3
    Conserved Domains (3) summary
    cd09942
    Location:59167
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:172332
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    cl15255
    Location:351396
    SH2; Src homology 2 (SH2) domain
  3. XM_030253316.2XP_030109176.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2

    Conserved Domains (3) summary
    cd09942
    Location:15123
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:128288
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    cl15255
    Location:307352
    SH2; Src homology 2 (SH2) domain