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TMEM25 transmembrane protein 25 [ Homo sapiens (human) ]

Gene ID: 84866, updated on 2-Mar-2021

Summary

Official Symbol
TMEM25provided by HGNC
Official Full Name
transmembrane protein 25provided by HGNC
Primary source
HGNC:HGNC:25890
See related
Ensembl:ENSG00000149582 MIM:613934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in duodenum (RPKM 15.5), small intestine (RPKM 11.2) and 24 other tissues See more
Orthologs
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Genomic context

See TMEM25 in Genome Data Viewer
Location:
11q23.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (118531189..118547286)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118401907..118418001)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene lysine methyltransferase 2A Neighboring gene uncharacterized LOC101929089 Neighboring gene tetratricopeptide repeat domain 36 Neighboring gene intraflagellar transport 46 Neighboring gene ribosomal protein L5 pseudogene 30 Neighboring gene archain 1 Neighboring gene RNA, U6 small nuclear 1157, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14399

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of excitatory postsynaptic potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein stability ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 25
Names
0610039J01Rik

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144034.2NP_001137506.1  transmembrane protein 25 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001137506.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon and uses an alternate splice junction in the 3' end compared to variant 7. The resulting isoform (2) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 6. Variants 2 and 6 both encode the same isoform (2).
    Source sequence(s)
    AP000941, AY358919, BC042896, BF513120
    Consensus CDS
    CCDS44747.1
    UniProtKB/Swiss-Prot
    Q86YD3
    Related
    ENSP00000352924.4, ENST00000359862.8
    Conserved Domains (1) summary
    cl11960
    Location:27118
    Ig; Immunoglobulin domain
  2. NM_001144035.2NP_001137507.1  transmembrane protein 25 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001137507.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks an alternate in-frame exon, and uses an alternate splice junction in the 3' end compared to variant 7. The resulting isoform (2) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 6. Variants 2 and 6 both encode the same isoform (2).
    Source sequence(s)
    AK292359, AP000941, BC042896, BF513120
    Consensus CDS
    CCDS44747.1
    UniProtKB/Swiss-Prot
    Q86YD3
    Related
    ENSP00000411882.2, ENST00000411589.6
    Conserved Domains (1) summary
    cl11960
    Location:27118
    Ig; Immunoglobulin domain
  3. NM_001144036.2NP_001137508.1  transmembrane protein 25 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001137508.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons and uses an alternate splice junction in the 3' end compared to variant 7. The resulting isoform (3) lacks two alternate internal segments and has a shorter and distinct C-terminus compared to isoform 6.
    Source sequence(s)
    AK056325, AP000941, BC042896, BF513120
    Consensus CDS
    CCDS44748.1
    UniProtKB/Swiss-Prot
    Q86YD3
    Related
    ENSP00000278959.8, ENST00000354064.11
  4. NM_001144037.2NP_001137509.1  transmembrane protein 25 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001137509.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 7. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 6.
    Source sequence(s)
    AK027305, AK075437, AP000941, BC042896, BF513120
    Consensus CDS
    CCDS44745.1
    UniProtKB/Swiss-Prot
    Q86YD3
    UniProtKB/TrEMBL
    A0A024R3G8
    Related
    ENSP00000346237.4, ENST00000354284.8
    Conserved Domains (1) summary
    pfam08205
    Location:27118
    C2-set_2; CD80-like C2-set immunoglobulin domain
  5. NM_001144038.2NP_001137510.1  transmembrane protein 25 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001137510.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon and differs in the 3' UTR and coding sequence compared to variant 7. The resulting isoform (5) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 6.
    Source sequence(s)
    AK075437, AK096260, AP000941
    Consensus CDS
    CCDS44746.1
    UniProtKB/Swiss-Prot
    Q86YD3
    Related
    ENSP00000416071.2, ENST00000442938.6
    Conserved Domains (1) summary
    cl11960
    Location:27118
    Ig; Immunoglobulin domain
  6. NM_001318755.2NP_001305684.1  transmembrane protein 25 isoform 6 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) encodes the longest isoform (6).
    Source sequence(s)
    AK225415, AP000941, BF513120
    Consensus CDS
    CCDS81630.1
    UniProtKB/Swiss-Prot
    Q86YD3
    UniProtKB/TrEMBL
    E9PKP3
    Related
    ENSP00000431548.1, ENST00000533102.5
    Conserved Domains (1) summary
    cl11960
    Location:27118
    Ig; Immunoglobulin domain
  7. NM_001318757.2NP_001305686.1  transmembrane protein 25 isoform 7 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an alternate in-frame exon and uses an alternate splice junction in the 3' end compared to variant 7. The resulting isoform (7) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 6.
    Source sequence(s)
    AK293670, AP000941, AY358919
    UniProtKB/Swiss-Prot
    Q86YD3
    UniProtKB/TrEMBL
    B7Z1M8
    Conserved Domains (1) summary
    cl11960
    Location:27118
    Ig; Immunoglobulin domain
  8. NM_032780.4NP_116169.2  transmembrane protein 25 isoform 1 precursor

    See identical proteins and their annotated locations for NP_116169.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate splice junction in the 3' end compared to variant 7. The resulting isoform (1) has a shorter and distinct C-terminus compared to isoform 6.
    Source sequence(s)
    AP000941, BC042896, BF513120
    Consensus CDS
    CCDS8398.1
    UniProtKB/Swiss-Prot
    Q86YD3
    Related
    ENSP00000315635.5, ENST00000313236.10
    Conserved Domains (1) summary
    pfam08205
    Location:27118
    C2-set_2; CD80-like C2-set immunoglobulin domain

RNA

  1. NR_134852.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks several exons and uses an alternate splice junction in the 3' end compared to variant 7. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK293670, AP000941, AY358919, BF513120, DA760733

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    118531189..118547286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018433.2XP_016873922.1  transmembrane protein 25 isoform X6

  2. XM_017018430.2XP_016873919.1  transmembrane protein 25 isoform X5

  3. XM_017018422.2XP_016873911.1  transmembrane protein 25 isoform X2

    UniProtKB/Swiss-Prot
    Q86YD3
    Conserved Domains (1) summary
    pfam08205
    Location:27118
    C2-set_2; CD80-like C2-set immunoglobulin domain
  4. XM_006718926.3XP_006718989.1  transmembrane protein 25 isoform X1

    See identical proteins and their annotated locations for XP_006718989.1

    Conserved Domains (1) summary
    cl11960
    Location:27118
    Ig; Immunoglobulin domain
  5. XM_011543038.3XP_011541340.1  transmembrane protein 25 isoform X3

    Conserved Domains (1) summary
    cl11960
    Location:27118
    Ig; Immunoglobulin domain
  6. XM_005271703.2XP_005271760.1  transmembrane protein 25 isoform X1

    See identical proteins and their annotated locations for XP_005271760.1

    Conserved Domains (1) summary
    cl11960
    Location:27118
    Ig; Immunoglobulin domain
  7. XM_017018432.2XP_016873921.1  transmembrane protein 25 isoform X6

  8. XM_024448724.1XP_024304492.1  transmembrane protein 25 isoform X4

    Related
    ENSP00000431205.1, ENST00000524725.5
    Conserved Domains (1) summary
    cl11960
    Location:27118
    Ig; Immunoglobulin domain
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