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ZNF577 zinc finger protein 577 [ Homo sapiens (human) ]

Gene ID: 84765, updated on 23-Nov-2021

Summary

Official Symbol
ZNF577provided by HGNC
Official Full Name
zinc finger protein 577provided by HGNC
Primary source
HGNC:HGNC:28673
See related
Ensembl:ENSG00000161551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in skin (RPKM 6.4), ovary (RPKM 5.9) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF577 in Genome Data Viewer
Location:
19q13.41
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (51804442..51887951, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52307695..52391204, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene formyl peptide receptor 2 Neighboring gene uncharacterized LOC105372448 Neighboring gene formyl peptide receptor 3 Neighboring gene zinc finger protein 84 pseudogene Neighboring gene vomeronasal 1 receptor 98 pseudogene Neighboring gene ZNF649 antisense RNA 1 Neighboring gene zinc finger protein 649 Neighboring gene zinc finger protein 41 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4400, FLJ32291, AC006272.1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135590.2NP_001129062.1  zinc finger protein 577 isoform b

    See identical proteins and their annotated locations for NP_001129062.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC011460, AC074141, AK289479, AK291812, BC004992, BU949047
    Consensus CDS
    CCDS46160.1
    UniProtKB/Swiss-Prot
    Q9BSK1
    Related
    ENSP00000389652.2, ENST00000451628.9
    Conserved Domains (3) summary
    smart00349
    Location:2583
    KRAB; krueppel associated box
    COG5048
    Location:135340
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:157177
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001370447.1NP_001357376.1  zinc finger protein 577 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC074141, AI004737, AK289479, DA747815
    Conserved Domains (3) summary
    smart00349
    Location:2583
    KRAB; krueppel associated box
    COG5048
    Location:194399
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:216236
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001370448.1NP_001357377.1  zinc finger protein 577 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC074141, AI004737, AK289479, DA747815, DA874803
    Conserved Domains (3) summary
    smart00349
    Location:2583
    KRAB; krueppel associated box
    COG5048
    Location:194399
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:216236
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001370449.1NP_001357378.1  zinc finger protein 577 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC074141, AI004737, AK093036, AK289479, AL832871
    Related
    ENSP00000491936.2, ENST00000638348.2
    Conserved Domains (3) summary
    smart00349
    Location:2583
    KRAB; krueppel associated box
    COG5048
    Location:194399
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:216236
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001370450.1NP_001357379.1  zinc finger protein 577 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC074141, AI004737, AK093036, AK289479, AK291812, AL832871
    Related
    ENSP00000491349.1, ENST00000639636.2
    Conserved Domains (3) summary
    smart00349
    Location:2583
    KRAB; krueppel associated box
    COG5048
    Location:135340
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:157177
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001370452.1NP_001357381.1  zinc finger protein 577 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC006272, AC011460, AC074141
    Conserved Domains (1) summary
    smart00349
    Location:2583
    KRAB; krueppel associated box
  7. NM_001370455.1NP_001357384.1  zinc finger protein 577 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC006272, AC011460, AC074141
    Conserved Domains (1) summary
    smart00349
    Location:2583
    KRAB; krueppel associated box
  8. NM_001370456.1NP_001357385.1  zinc finger protein 577 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC006272, AC011460, AC074141
    Conserved Domains (1) summary
    smart00349
    Location:2583
    KRAB; krueppel associated box
  9. NM_001370457.1NP_001357386.1  zinc finger protein 577 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC006272, AC011460, AC074141
    Related
    ENSP00000492704.1, ENST00000638827.1
    Conserved Domains (1) summary
    smart00349
    Location:2583
    KRAB; krueppel associated box
  10. NM_032679.3NP_116068.2  zinc finger protein 577 isoform a

    See identical proteins and their annotated locations for NP_116068.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC074141, AK289479, BC004992, BU949047
    Consensus CDS
    CCDS12842.2
    UniProtKB/Swiss-Prot
    Q9BSK1
    UniProtKB/TrEMBL
    A0A024R4N6
    Related
    ENSP00000301399.5, ENST00000301399.12
    Conserved Domains (3) summary
    smart00349
    Location:2583
    KRAB; krueppel associated box
    COG5048
    Location:194399
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:216236
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_163433.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005946, AC006272, AC011460, AC074141

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    51804442..51887951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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