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CAPS2 calcyphosine 2 [ Homo sapiens (human) ]

Gene ID: 84698, updated on 26-Oct-2022

Summary

Official Symbol
CAPS2provided by HGNC
Official Full Name
calcyphosine 2provided by HGNC
Primary source
HGNC:HGNC:16471
See related
Ensembl:ENSG00000180881 MIM:607724; AllianceGenome:HGNC:16471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UG0636c06
Summary
Calcyphosine-2 is a calcium-binding protein with 2 EF-hand motifs (Wang et al., 2002 [PubMed 11846421]).[supplied by OMIM, Mar 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See CAPS2 in Genome Data Viewer
Location:
12q21.1-q21.2
Exon count:
26
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (75275979..75390901, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (75250589..75365485, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (75669759..75784681, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100130268 Neighboring gene CAPS2 antisense RNA 1 Neighboring gene cyclin G2 pseudogene 1 Neighboring gene necdin, MAGE family member pseudogene Neighboring gene GLIPR1 like 1 Neighboring gene uncharacterized LOC124902968 Neighboring gene GLIPR1 like 2 Neighboring gene GLIPR1 antisense RNA 1 Neighboring gene GLI pathogenesis related 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of calcyphosine 2 protein (CAPS2) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Clone Names

  • FLJ34520

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcyphosin-2
Names
calcyphosphine 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286547.3NP_001273476.1  calcyphosin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092552, AK091839, BC033860
    UniProtKB/TrEMBL
    B9A061
    Related
    ENSP00000386977.2, ENST00000409799.6
    Conserved Domains (3) summary
    cd00051
    Location:372428
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:368428
    EF-hand_7; EF-hand domain pair
    cl00723
    Location:326362
    YajQ_like; Proteins similar to Escherichia coli YajQ
  2. NM_001286548.3NP_001273477.1  calcyphosin-2 isoform 3

    See identical proteins and their annotated locations for NP_001273477.1

    Status: VALIDATED

    Source sequence(s)
    AC091534, AC092552, AF251056, AK092274, BC033860, BG186487
    UniProtKB/Swiss-Prot
    Q9BXY5
    Conserved Domains (4) summary
    cd00051
    Location:222278
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl00723
    Location:176212
    YajQ_like; Proteins similar to Escherichia coli YajQ
    cl25352
    Location:222377
    EFh_PEF; The penta-EF hand (PEF) family
    cl25732
    Location:68155
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_001355023.4NP_001341952.2  calcyphosin-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC091534, AC092552, AC121761
  4. NM_001355024.4NP_001341953.2  calcyphosin-2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC091534, AC092552
    Consensus CDS
    CCDS91727.1
    Related
    ENSP00000514274.1, ENST00000699294.1
  5. NM_001355025.2NP_001341954.1  calcyphosin-2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC091534, AC092552, AC121761, BC033860
    Conserved Domains (3) summary
    cd00051
    Location:368424
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl00723
    Location:322358
    YajQ_like; Proteins similar to Escherichia coli YajQ
    cl25352
    Location:368523
    EFh_PEF; The penta-EF hand (PEF) family
  6. NM_001355026.2NP_001341955.1  calcyphosin-2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC091534, AC092552, AC121761, BC033860
    Conserved Domains (3) summary
    cd00051
    Location:317373
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl00723
    Location:271307
    YajQ_like; Proteins similar to Escherichia coli YajQ
    cl25352
    Location:317472
    EFh_PEF; The penta-EF hand (PEF) family
  7. NM_001355027.2NP_001341956.1  calcyphosin-2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC091534, AC092552, AC121761, BC033860
    Conserved Domains (2) summary
    cd00051
    Location:368424
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl00723
    Location:322358
    YajQ_like; Proteins similar to Escherichia coli YajQ
  8. NM_001355030.2NP_001341959.1  calcyphosin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC091534, AC092552, AC121761, BC033860
    Conserved Domains (4) summary
    cd00051
    Location:222278
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl00723
    Location:176212
    YajQ_like; Proteins similar to Escherichia coli YajQ
    cl25352
    Location:222377
    EFh_PEF; The penta-EF hand (PEF) family
    cl25732
    Location:68155
    SMC_N; RecF/RecN/SMC N terminal domain
  9. NM_001355031.2NP_001341960.1  calcyphosin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC091534, AC092552, AC121761, BC033860
    Conserved Domains (4) summary
    cd00051
    Location:222278
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl00723
    Location:176212
    YajQ_like; Proteins similar to Escherichia coli YajQ
    cl25352
    Location:222377
    EFh_PEF; The penta-EF hand (PEF) family
    cl25732
    Location:68155
    SMC_N; RecF/RecN/SMC N terminal domain
  10. NM_001355032.2NP_001341961.1  calcyphosin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC091534, AC092552, AC121761, BC033860
    Conserved Domains (4) summary
    cd00051
    Location:222278
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl00723
    Location:176212
    YajQ_like; Proteins similar to Escherichia coli YajQ
    cl25352
    Location:222377
    EFh_PEF; The penta-EF hand (PEF) family
    cl25732
    Location:68155
    SMC_N; RecF/RecN/SMC N terminal domain
  11. NM_001355033.2NP_001341962.1  calcyphosin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC091534, AC092552, AC121761, BC033860
    Conserved Domains (4) summary
    cd00051
    Location:222278
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl00723
    Location:176212
    YajQ_like; Proteins similar to Escherichia coli YajQ
    cl25352
    Location:222377
    EFh_PEF; The penta-EF hand (PEF) family
    cl25732
    Location:68155
    SMC_N; RecF/RecN/SMC N terminal domain
  12. NM_032606.5NP_115995.2  calcyphosin-2 isoform 1

    See identical proteins and their annotated locations for NP_115995.2

    Status: VALIDATED

    Source sequence(s)
    AC092552, AF351611, AK091839, BC033860
    UniProtKB/Swiss-Prot
    Q8NAY5, Q9BXY5
    Related
    ENSP00000386959.4, ENST00000409445.8
    Conserved Domains (3) summary
    cd00051
    Location:454510
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:450510
    EF-hand_7; EF-hand domain pair
    cl00723
    Location:408444
    YajQ_like; Proteins similar to Escherichia coli YajQ

RNA

  1. NR_149155.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091534, AC092552, AC121761, BC033860
  2. NR_149156.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091534, AC092552, AC121761, BC033860
  3. NR_149157.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091534, AC092552, AC121761, BC033860
  4. NR_149158.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091534, AC092552, AC121761, BC033860
  5. NR_149159.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091534, AC092552, AC121761, BC033860
  6. NR_149160.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091534, AC092552, AC121761, BC033860
  7. NR_149161.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091534, AC092552, AC121761, BC033860

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    75275979..75390901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538888.1XP_011537190.1  calcyphosin-2 isoform X4

    Conserved Domains (3) summary
    cd00051
    Location:349405
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:345405
    EF-hand_7; EF-hand domain pair
    cl00723
    Location:303339
    YajQ_like; Proteins similar to Escherichia coli YajQ
  2. XM_047429730.1XP_047285686.1  calcyphosin-2 isoform X2

    Related
    ENSP00000376963.4, ENST00000393284.8
  3. XM_047429727.1XP_047285683.1  calcyphosin-2 isoform X1

  4. XM_047429729.1XP_047285685.1  calcyphosin-2 isoform X2

  5. XM_047429726.1XP_047285682.1  calcyphosin-2 isoform X1

  6. XM_047429724.1XP_047285680.1  calcyphosin-2 isoform X1

  7. XM_011538889.4XP_011537191.1  calcyphosin-2 isoform X2

    See identical proteins and their annotated locations for XP_011537191.1

    Conserved Domains (3) summary
    cd00051
    Location:442498
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:438498
    EF-hand_7; EF-hand domain pair
    cl00723
    Location:396432
    YajQ_like; Proteins similar to Escherichia coli YajQ
  8. XM_047429725.1XP_047285681.1  calcyphosin-2 isoform X1

  9. XM_047429728.1XP_047285684.1  calcyphosin-2 isoform X2

  10. XM_011538878.2XP_011537180.1  calcyphosin-2 isoform X2

    See identical proteins and their annotated locations for XP_011537180.1

    Conserved Domains (3) summary
    cd00051
    Location:442498
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:438498
    EF-hand_7; EF-hand domain pair
    cl00723
    Location:396432
    YajQ_like; Proteins similar to Escherichia coli YajQ
  11. XM_011538887.3XP_011537189.1  calcyphosin-2 isoform X3

    Conserved Domains (3) summary
    cd00051
    Location:384440
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:380440
    EF-hand_7; EF-hand domain pair
    cl00723
    Location:338374
    YajQ_like; Proteins similar to Escherichia coli YajQ
  12. XM_047429731.1XP_047285687.1  calcyphosin-2 isoform X6

  13. XM_011538890.2XP_011537192.1  calcyphosin-2 isoform X5

RNA

  1. XR_944789.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    75250589..75365485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)