U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TPST2 tyrosylprotein sulfotransferase 2 [ Homo sapiens (human) ]

Gene ID: 8459, updated on 1-Mar-2024

Summary

Official Symbol
TPST2provided by HGNC
Official Full Name
tyrosylprotein sulfotransferase 2provided by HGNC
Primary source
HGNC:HGNC:12021
See related
Ensembl:ENSG00000128294 MIM:603126; AllianceGenome:HGNC:12021
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TPST-2; TANGO13B
Summary
The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. The encoded protein is a type II integral membrane protein found in the Golgi body. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]
Expression
Ubiquitous expression in pancreas (RPKM 24.6), placenta (RPKM 15.2) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TPST2 in Genome Data Viewer
Location:
22q12.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (26521996..26590132, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (26984404..27052464, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (26917962..26986096, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:26889254-26890453 Neighboring gene SRR1 domain containing Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13570 Neighboring gene tuftelin interacting protein 11 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr22:26902046-26903245 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:26908724-26909261 Neighboring gene TFIP11 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:26937311-26937812 Neighboring gene Sharpr-MPRA regulatory region 3066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:26951753-26952722 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:26959537-26960060 Neighboring gene microRNA 548j Neighboring gene hESC enhancers GRCh37_chr22:26963727-26964250 and GRCh37_chr22:26964251-26964774 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:26964775-26965298 Neighboring gene high mobility group box 1 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18793 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr22:26975739-26976656 and GRCh37_chr22:26976657-26977573 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:26985294-26985794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18795 Neighboring gene crystallin beta A4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27003362-27004004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13574 Neighboring gene crystallin beta B1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr22:27009656-27010334 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27013045-27013722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27014401-27015076 Neighboring gene CRISPRi-validated cis-regulatory element chr22.1058 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27037805-27038669 Neighboring gene Sharpr-MPRA regulatory region 8650 Neighboring gene Sharpr-MPRA regulatory region 12592 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27041123-27041688 Neighboring gene iron-sulfur cluster assembly 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is sulfated at positions Y173 and Y177 in the V2 domain by tyrosyl sulfotransferase 2 (TPST2), leading to modulate gp120 epitope exposure and neutralization sensitivity PubMed
env Sulfation of CCR5 by tyrosylprotein sulfotranferase-2 is crucial for mediating interaction with HIV-1 gp120. The pattern and the rate of sulfation for CCR5 depend on the number of amino acids N-terminal of Tyr-3 PubMed
env The chemokine receptor CCR5 is posttranslationally modified by sulfation of its N-terminal tyrosines; sulfated tyrosines contribute to the binding of CCR5 to MIP-1 alpha, MIP-1 beta, and HIV-1 gp120/CD4 complexes and to the ability of HIV-1 to enter cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-tyrosine sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-tyrosine sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-tyrosine sulfotransferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
Traceable Author Statement
more info
 
involved_in peptidyl-tyrosine sulfation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-tyrosine sulfation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein-tyrosine sulfotransferase 2
Names
transport and golgi organization 13 homolog B
tyrosylprotein phosphotransferase 2
NP_001008566.1
NP_001349851.1
NP_001349852.1
NP_003586.3
XP_024308062.1
XP_047297505.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008566.3NP_001008566.1  protein-tyrosine sulfotransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_001008566.1

    Status: REVIEWED

    Source sequence(s)
    Z95115
    Consensus CDS
    CCDS13839.1
    UniProtKB/Swiss-Prot
    B3KQA7, O60704, Q6FI98, Q9H0V4
    UniProtKB/TrEMBL
    B7Z976
    Related
    ENSP00000381180.2, ENST00000398110.6
    Conserved Domains (1) summary
    pfam13469
    Location:71262
    Sulfotransfer_3; Sulfotransferase family
  2. NM_001362922.2NP_001349851.1  protein-tyrosine sulfotransferase 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    Z95115
    Consensus CDS
    CCDS13839.1
    UniProtKB/Swiss-Prot
    B3KQA7, O60704, Q6FI98, Q9H0V4
    UniProtKB/TrEMBL
    B7Z976
    Conserved Domains (1) summary
    pfam13469
    Location:71262
    Sulfotransfer_3; Sulfotransferase family
  3. NM_001362923.2NP_001349852.1  protein-tyrosine sulfotransferase 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    Z95115
    Conserved Domains (1) summary
    pfam13469
    Location:125316
    Sulfotransfer_3; Sulfotransferase family
  4. NM_003595.5NP_003586.3  protein-tyrosine sulfotransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_003586.3

    Status: REVIEWED

    Source sequence(s)
    Z95115
    Consensus CDS
    CCDS13839.1
    UniProtKB/Swiss-Prot
    B3KQA7, O60704, Q6FI98, Q9H0V4
    UniProtKB/TrEMBL
    B7Z976
    Related
    ENSP00000339813.4, ENST00000338754.9
    Conserved Domains (1) summary
    pfam13469
    Location:71262
    Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    26521996..26590132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441549.1XP_047297505.1  protein-tyrosine sulfotransferase 2 isoform X2

  2. XM_024452294.2XP_024308062.1  protein-tyrosine sulfotransferase 2 isoform X1

    Conserved Domains (1) summary
    pfam13469
    Location:141332
    Sulfotransfer_3; Sulfotransferase family

RNA

  1. XR_007067981.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    26984404..27052464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)