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PARD6G par-6 family cell polarity regulator gamma [ Homo sapiens (human) ]

Gene ID: 84552, updated on 8-Jul-2021

Summary

Official Symbol
PARD6Gprovided by HGNC
Official Full Name
par-6 family cell polarity regulator gammaprovided by HGNC
Primary source
HGNC:HGNC:16076
See related
Ensembl:ENSG00000178184 MIM:608976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAR-6G; PAR6gamma
Expression
Broad expression in skin (RPKM 15.6), esophagus (RPKM 5.7) and 15 other tissues See more
Orthologs
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Genomic context

See PARD6G in Genome Data Viewer
Location:
18q23
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (80157232..80247514, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (77915115..78005397, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RBFA downstream neighbor Neighboring gene solute carrier family 25 member 6 pseudogene 4 Neighboring gene ADNP homeobox 2 Neighboring gene PARD6G antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif modulates the expression of par-6 family cell polarity regulator gamma (PARD6G) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45701

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cellular localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
partitioning defective 6 homolog gamma
Names
PAR-6 gamma protein
PAR6D
par-6 partitioning defective 6 homolog gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032510.4NP_115899.1  partitioning defective 6 homolog gamma

    See identical proteins and their annotated locations for NP_115899.1

    Status: VALIDATED

    Source sequence(s)
    AA502508, AC139100, BC060797
    Consensus CDS
    CCDS12022.1
    UniProtKB/Swiss-Prot
    Q9BYG4
    Related
    ENSP00000343144.3, ENST00000353265.8
    Conserved Domains (2) summary
    cd06403
    Location:1998
    PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...
    cd00992
    Location:157248
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    80157232..80247514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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