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DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 [ Homo sapiens (human) ]

Gene ID: 8445, updated on 27-Nov-2024

Summary

Official Symbol
DYRK2provided by HGNC
Official Full Name
dual specificity tyrosine phosphorylation regulated kinase 2provided by HGNC
Primary source
HGNC:HGNC:3093
See related
Ensembl:ENSG00000127334 MIM:603496; AllianceGenome:HGNC:3093
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 11.8), small intestine (RPKM 10.4) and 25 other tissues See more
Orthologs
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Genomic context

See DYRK2 in Genome Data Viewer
Location:
12q15
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (67648745..67665406)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (67628264..67644920)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (68042525..68059186)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:67913523-67914188 Neighboring gene long intergenic non-protein coding RNA 2408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4640 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:67948831-67949332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:67949333-67949832 Neighboring gene long intergenic non-protein coding RNA 2442 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:67983387-67983606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4641 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6630 Neighboring gene uncharacterized LOC105369816 Neighboring gene uncharacterized LOC124902958

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of dual-specificity tyrosine (Y)-phosphorylation regulated kinase 2 (DYRK2) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ21217, FLJ21365

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H2AXY142 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3Y41 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 2
Names
dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2
NP_003574.1
NP_006473.2
XP_016875521.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003583.4NP_003574.1  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_003574.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) does not include the 149 bp insert in the 5' end of the transcript and thus results in a shorter amino-terminal protein.
    Source sequence(s)
    AC078777, AK025018, BC005809, BC006375, CN303286, DA768075, DB461362
    Consensus CDS
    CCDS8979.1
    UniProtKB/Swiss-Prot
    Q92630
    Related
    ENSP00000377186.3, ENST00000393555.3
    Conserved Domains (1) summary
    cd14224
    Location:83462
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
  2. NM_006482.3NP_006473.2  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_006473.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes the 149 bp insert in the 5' end of the transcript and thus results in a longer amino-terminal protein.
    Source sequence(s)
    AC078777, AK025018, BC005809, BC006375, CN303286, DA768075, DB461362
    Consensus CDS
    CCDS8978.1
    UniProtKB/Swiss-Prot
    B2R9V9, Q92630, Q9BRB5
    Related
    ENSP00000342105.4, ENST00000344096.4
    Conserved Domains (1) summary
    cd14224
    Location:156535
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    67648745..67665406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020032.2XP_016875521.1  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q92630
    Conserved Domains (1) summary
    cd14224
    Location:83462
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    67628264..67644920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)