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DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 [ Homo sapiens (human) ]

Gene ID: 8445, updated on 6-Jan-2019

Summary

Official Symbol
DYRK2provided by HGNC
Official Full Name
dual specificity tyrosine phosphorylation regulated kinase 2provided by HGNC
Primary source
HGNC:HGNC:3093
See related
Ensembl:ENSG00000127334 MIM:603496
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 11.8), small intestine (RPKM 10.4) and 25 other tissues See more
Orthologs

Genomic context

See DYRK2 in Genome Data Viewer
Location:
12q15
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (67648732..67665405)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (68042512..68056444)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2408 Neighboring gene long intergenic non-protein coding RNA 2442 Neighboring gene uncharacterized LOC105369816 Neighboring gene long intergenic non-protein coding RNA 2421

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of dual-specificity tyrosine (Y)-phosphorylation regulated kinase 2 (DYRK2) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
  • Regulation of TP53 Activity through Phosphorylation, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity through Phosphorylation, organism-specific biosystemPhosphorylation of TP53 (p53) at the N-terminal serine residues S15 and S20 plays a critical role in protein stabilization as phosphorylation at these sites interferes with binding of the ubiquitin l...
  • T-Cell Receptor and Co-stimulatory Signaling, organism-specific biosystem (from WikiPathways)
    T-Cell Receptor and Co-stimulatory Signaling, organism-specific biosystemThe activation and translocation of transcription factors NFAT, AP-1 and NF-kappa-B via the co-stimulatory signaling cascade triggered by MHC peptide, B7 proteins and PD-L1. The activation of NFAT in...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
  • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
    p53 pathway, organism-specific biosystem
    p53 pathway

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21217, FLJ21365

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 2
Names
dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2
NP_003574.1
NP_006473.2
XP_016875521.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003583.3NP_003574.1  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_003574.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) does not include the 149 bp insert in the 5' end of the transcript and thus results in a shorter amino-terminal protein.
    Source sequence(s)
    AC078777, AK025018, BC005809, BC006375, CN303286, DA768075, DB461362
    Consensus CDS
    CCDS8979.1
    UniProtKB/Swiss-Prot
    Q92630
    Related
    ENSP00000377186.3, ENST00000393555.3
    Conserved Domains (1) summary
    cd14224
    Location:83462
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
  2. NM_006482.2NP_006473.2  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_006473.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes the 149 bp insert in the 5' end of the transcript and thus results in a longer amino-terminal protein.
    Source sequence(s)
    AC078777, AK025018, BC005809, BC006375, CN303286, DA768075, DB461362
    Consensus CDS
    CCDS8978.1
    UniProtKB/Swiss-Prot
    Q92630
    Related
    ENSP00000342105.3, ENST00000344096.3
    Conserved Domains (1) summary
    cd14224
    Location:156535
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    67648732..67665405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020032.1XP_016875521.1  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q92630
    Conserved Domains (1) summary
    cd14224
    Location:83462
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
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