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Dyrk2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 69181, updated on 26-Sep-2022

Summary

Official Symbol
Dyrk2provided by MGI
Official Full Name
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2provided by MGI
Primary source
MGI:MGI:1330301
See related
Ensembl:ENSMUSG00000028630 AllianceGenome:MGI:1330301
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810038L18Rik
Summary
Predicted to enable ATP binding activity; metal ion binding activity; and protein kinase activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of calcineurin-NFAT signaling cascade; and protein phosphorylation. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation. Part of ribonucleoprotein complex. Is expressed in several structures, including brain; eye; gut gland; hemolymphoid system gland; and reproductive system. Orthologous to human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 10.4), large intestine adult (RPKM 9.8) and 28 other tissues See more
Orthologs
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Genomic context

See Dyrk2 in Genome Data Viewer
Location:
10; 10 D2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (118691507..118725144, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (118855602..118889245, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33481 Neighboring gene predicted gene, 40776 Neighboring gene predicted gene, 40777 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 38403 Neighboring gene predicted gene, 33624

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 2
NP_001014412.1
XP_006514109.3
XP_011241854.1
XP_036011873.1
XP_036011874.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014390.2NP_001014412.1  dual specificity tyrosine-phosphorylation-regulated kinase 2

    See identical proteins and their annotated locations for NP_001014412.1

    Status: PROVISIONAL

    Source sequence(s)
    AC154039
    Consensus CDS
    CCDS24201.1
    UniProtKB/Swiss-Prot
    Q5U4C9
    Related
    ENSMUSP00000004281.9, ENSMUST00000004281.10
    Conserved Domains (2) summary
    smart00220
    Location:220533
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14224
    Location:154533
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    118691507..118725144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243552.3XP_011241854.1  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X2

    See identical proteins and their annotated locations for XP_011241854.1

    Conserved Domains (1) summary
    cd14224
    Location:81460
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
  2. XM_036155980.1XP_036011873.1  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X2

    Conserved Domains (1) summary
    cd14224
    Location:81460
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
  3. XM_006514046.5XP_006514109.3  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1

    Conserved Domains (1) summary
    cd14224
    Location:220599
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
  4. XM_036155981.1XP_036011874.1  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X2

    Conserved Domains (1) summary
    cd14224
    Location:81460
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3