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RAB11FIP4 RAB11 family interacting protein 4 [ Homo sapiens (human) ]

Gene ID: 84440, updated on 17-Jun-2019

Summary

Official Symbol
RAB11FIP4provided by HGNC
Official Full Name
RAB11 family interacting protein 4provided by HGNC
Primary source
HGNC:HGNC:30267
See related
Ensembl:ENSG00000131242 MIM:611999
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FIP4-Rab11; RAB11-FIP4
Summary
The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016]
Expression
Broad expression in brain (RPKM 25.4), testis (RPKM 6.0) and 17 other tissues See more
Orthologs

Genomic context

See RAB11FIP4 in Genome Data Viewer
Location:
17q11.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (31391675..31538211)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (29718642..29865232)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene neurofibromin 1 Neighboring gene NF1 intron 50 Alu-mediated recombination region Neighboring gene adenylate kinase 4 pseudogene 1 Neighboring gene uncharacterized LOC105371725 Neighboring gene RNA, 7SL, cytoplasmic 79, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 45, pseudogene Neighboring gene tRNA-Thr (anticodon CGT) 4-1 Neighboring gene microRNA 4724 Neighboring gene microRNA 193a

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00131, KIAA1821, MGC11316, MGC126566

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP-ribosylation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ADP-ribosylation factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Rab GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neural retina development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of G1 to G0 transition IEA
Inferred from Electronic Annotation
more info
 
regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space HDA PubMed 
midbody IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rab11 family-interacting protein 4
Names
RAB11 family interacting protein 4 (class II)
arfophilin-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051977.1 RefSeqGene

    Range
    5001..151594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001303542.3NP_001290471.2  rab11 family-interacting protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001290471.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB058724, AJ314646, AK097424, AL831830, BC047674
    Consensus CDS
    CCDS76985.1
    UniProtKB/Swiss-Prot
    Q86YS3
    Related
    ENSP00000378227.2, ENST00000394744.6
    Conserved Domains (1) summary
    cl25732
    Location:238519
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001346747.2NP_001333676.1  rab11 family-interacting protein 4 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC003101, KF510421
  3. NM_001346748.2NP_001333677.1  rab11 family-interacting protein 4 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC003101, AJ314646, KF510421
    UniProtKB/Swiss-Prot
    Q86YS3
    Conserved Domains (2) summary
    pfam09457
    Location:455495
    RBD-FIP; FIP domain
    cl25732
    Location:199480
    SMC_N; RecF/RecN/SMC N terminal domain
  4. NM_001346749.2NP_001333678.1  rab11 family-interacting protein 4 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC003101, AJ314646, DA956442, KF510421
    UniProtKB/Swiss-Prot
    Q86YS3
    Conserved Domains (2) summary
    pfam09457
    Location:336376
    RBD-FIP; FIP domain
    cl25732
    Location:80361
    SMC_N; RecF/RecN/SMC N terminal domain
  5. NM_032932.6NP_116321.2  rab11 family-interacting protein 4 isoform 1

    See identical proteins and their annotated locations for NP_116321.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AJ314646, AY169244, BC047674, BC093914
    Consensus CDS
    CCDS11267.1
    UniProtKB/Swiss-Prot
    Q86YS3
    Related
    ENSP00000482620.1, ENST00000621161.5
    Conserved Domains (2) summary
    pfam13499
    Location:2076
    EF-hand_7; EF-hand domain pair
    cl25732
    Location:340621
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    31391675..31538211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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