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Rab11fip4 RAB11 family interacting protein 4 (class II) [ Mus musculus (house mouse) ]

Gene ID: 268451, updated on 5-Aug-2022

Summary

Official Symbol
Rab11fip4provided by MGI
Official Full Name
RAB11 family interacting protein 4 (class II)provided by MGI
Primary source
MGI:MGI:2442920
See related
Ensembl:ENSMUSG00000017639 AllianceGenome:MGI:2442920
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1821; RAB11-FIP4; A730072L08Rik
Summary
Predicted to enable protein homodimerization activity and small GTPase binding activity. Acts upstream of or within neural retina development and positive regulation of G1 to G0 transition. Located in perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; gut; respiratory system; sensory organ; and skeleton. Orthologous to human RAB11FIP4 (RAB11 family interacting protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 31.5), frontal lobe adult (RPKM 30.4) and 19 other tissues See more
Orthologs
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Genomic context

See Rab11fip4 in Genome Data Viewer
Location:
11 B5; 11 46.88 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (79481847..79588842)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (79591021..79698016)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (79404714..79507514)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene neurofibromin 1 Neighboring gene ecotropic viral integration site 2b Neighboring gene ecotropic viral integration site 2 Neighboring gene ecotropic viral integration site 2a Neighboring gene RAB11 family interacting protein 4 (class II), opposite strand 1 Neighboring gene predicted gene, 23293 Neighboring gene predicted gene, 25867 Neighboring gene predicted gene, 30718 Neighboring gene predicted gene, 24887 Neighboring gene RAB11 family interacting protein 4 (class II), opposite strand 2 Neighboring gene nuclear encoded tRNA threonine 3 (anticodon CGT) Neighboring gene predicted gene 11205 Neighboring gene microRNA 193a

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1821

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
is_active_in recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rab11 family-interacting protein 4
Names
FIP4-Rab11
mRab11-FIP4A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175543.3NP_780752.1  rab11 family-interacting protein 4

    See identical proteins and their annotated locations for NP_780752.1

    Status: PROVISIONAL

    Source sequence(s)
    AK046734
    Consensus CDS
    CCDS25123.1
    UniProtKB/Swiss-Prot
    Q80T87, Q8BQP8
    Related
    ENSMUSP00000017783.7, ENSMUST00000017783.13
    Conserved Domains (3) summary
    pfam09457
    Location:594634
    RBD-FIP; FIP domain
    pfam13499
    Location:2178
    EF-hand_7; EF-hand domain pair
    cl03075
    Location:426510
    GrpE; nucleotide exchange factor GrpE

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    79481847..79588842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533403.2XP_006533466.1  rab11 family-interacting protein 4 isoform X1

    Conserved Domains (3) summary
    COG1196
    Location:315545
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09457
    Location:571611
    RBD-FIP; FIP domain
    pfam13499
    Location:2078
    EF-hand_7; EF-hand domain pair
  2. XM_036156717.1XP_036012610.1  rab11 family-interacting protein 4 isoform X2

    Conserved Domains (2) summary
    TIGR02168
    Location:278560
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam09457
    Location:535575
    RBD-FIP; FIP domain
  3. XM_036156719.1XP_036012612.1  rab11 family-interacting protein 4 isoform X5

    Conserved Domains (1) summary
    pfam13499
    Location:2078
    EF-hand_7; EF-hand domain pair
  4. XM_030246035.2XP_030101895.1  rab11 family-interacting protein 4 isoform X4

    Conserved Domains (2) summary
    COG1196
    Location:199429
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09457
    Location:455495
    RBD-FIP; FIP domain
  5. XM_006533404.4XP_006533467.1  rab11 family-interacting protein 4 isoform X3

    Conserved Domains (2) summary
    COG1196
    Location:236466
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09457
    Location:492532
    RBD-FIP; FIP domain