Format

Send to:

Choose Destination

DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 [ Homo sapiens (human) ]

Gene ID: 8444, updated on 18-Aug-2020

Summary

Official Symbol
DYRK3provided by HGNC
Official Full Name
dual specificity tyrosine phosphorylation regulated kinase 3provided by HGNC
Primary source
HGNC:HGNC:3094
See related
Ensembl:ENSG00000143479 MIM:603497
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RED; REDK; DYRK5; hYAK3-2
Summary
This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 8.5), gall bladder (RPKM 5.7) and 19 other tissues See more
Orthologs

Genomic context

See DYRK3 in Genome Data Viewer
Location:
1q32.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (206635536..206655158)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (206808881..206823229)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Ras association domain family member 5 Neighboring gene ribosomal protein L7a pseudogene 20 Neighboring gene eukaryotic translation initiation factor 2D Neighboring gene DYRK3 antisense RNA 1 Neighboring gene MAPK activated protein kinase 2 Neighboring gene ribosomal protein S14 pseudogene 1 Neighboring gene uncharacterized LOC105372877

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
nuclear speck organization IDA
Inferred from Direct Assay
more info
PubMed 
organelle disassembly IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell cycle G2/M phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell cycle G2/M phase transition IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
stress granule disassembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress granule disassembly IDA
Inferred from Direct Assay
more info
PubMed 
stress granule disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
pericentriolar material IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 3
Names
dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5
protein kinase Dyrk3
regulatory erythroid kinase
NP_001004023.1
NP_003573.2
XP_005273372.1
XP_011508363.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004023.3NP_001004023.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform b

    See identical proteins and their annotated locations for NP_001004023.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional segment in the coding region compared to variant 1. The resulting isoform (b), also known as the isoform RED-S, contains a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL591846, AU126055, BC015501, Y12735
    Consensus CDS
    CCDS31000.1
    UniProtKB/Swiss-Prot
    O43781
    Related
    ENSP00000356075.3, ENST00000367108.7
    Conserved Domains (2) summary
    smart00220
    Location:189502
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14224
    Location:123502
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
  2. NM_003582.4NP_003573.2  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform a

    See identical proteins and their annotated locations for NP_003573.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript, but encodes the longer isoform (a), also known as the RED-L isoform.
    Source sequence(s)
    AL591846, AU126055, BC015501, Y12735
    Consensus CDS
    CCDS30999.1
    UniProtKB/Swiss-Prot
    O43781
    Related
    ENSP00000356076.2, ENST00000367109.7
    Conserved Domains (2) summary
    smart00220
    Location:209522
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14224
    Location:143522
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    206635536..206655158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273315.4XP_005273372.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1

    See identical proteins and their annotated locations for XP_005273372.1

    UniProtKB/Swiss-Prot
    O43781
    Related
    ENSP00000356073.1, ENST00000367106.1
    Conserved Domains (2) summary
    smart00220
    Location:189502
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14224
    Location:123502
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
  2. XM_011510061.2XP_011508363.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:174487
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14224
    Location:108487
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
Support Center