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Dyrk3 dual-specificity tyrosine phosphorylation regulated kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 226419, updated on 21-Apr-2024

Summary

Official Symbol
Dyrk3provided by MGI
Official Full Name
dual-specificity tyrosine phosphorylation regulated kinase 3provided by MGI
Primary source
MGI:MGI:1330300
See related
Ensembl:ENSMUSG00000016526 AllianceGenome:MGI:1330300
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including erythrocyte differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; and protein phosphorylation. Predicted to be located in several cellular components, including cytoplasmic stress granule; nuclear speck; and pericentriolar material. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; hemolymphoid system gland; musculature; nasal cavity epithelium; and reproductive system. Orthologous to human DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 67.2), liver E14.5 (RPKM 10.2) and 7 other tissues See more
Orthologs
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Genomic context

Location:
1 E4; 1 56.9 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131056178..131065991, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131128441..131138234, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene MAP kinase-activated protein kinase 2 Neighboring gene predicted gene, 25549 Neighboring gene STARR-positive B cell enhancer ABC_E5794 Neighboring gene predicted gene, 51643 Neighboring gene STARR-seq mESC enhancer starr_02208 Neighboring gene STARR-positive B cell enhancer ABC_E5795 Neighboring gene STARR-seq mESC enhancer starr_02210 Neighboring gene eukaryotic translation initiation factor 2D Neighboring gene Ras association (RalGDS/AF-6) domain family member 5 Neighboring gene STARR-positive B cell enhancer ABC_E11692 Neighboring gene STARR-seq mESC enhancer starr_02214 Neighboring gene bystin-like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear speck organization ISO
Inferred from Sequence Orthology
more info
 
involved_in organelle disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell cycle G2/M phase transition IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell cycle G2/M phase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cellular response to stress ISO
Inferred from Sequence Orthology
more info
 
involved_in stress granule disassembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in stress granule disassembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in pericentriolar material ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 3
Names
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
NP_001404999.1
NP_001405000.1
NP_001405001.1
NP_001405002.1
NP_001405003.1
NP_001405004.1
NP_663483.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418070.1NP_001404999.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL513351
  2. NM_001418071.1NP_001405000.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL513351
  3. NM_001418072.1NP_001405001.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL513351
  4. NM_001418073.1NP_001405002.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL513351
  5. NM_001418074.1NP_001405003.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL513351
  6. NM_001418075.1NP_001405004.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL513351
  7. NM_145508.3NP_663483.1  dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform a

    See identical proteins and their annotated locations for NP_663483.1

    Status: VALIDATED

    Source sequence(s)
    AL513351
    Consensus CDS
    CCDS15267.1
    UniProtKB/Swiss-Prot
    Q8BM34, Q922Y0
    Related
    ENSMUSP00000016670.8, ENSMUST00000016670.9
    Conserved Domains (2) summary
    smart00220
    Location:208521
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14224
    Location:142521
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    131056178..131065991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)