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BRMS1L BRMS1 like transcriptional repressor [ Homo sapiens (human) ]

Gene ID: 84312, updated on 2-Nov-2024

Summary

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Official Symbol
BRMS1Lprovided by HGNC
Official Full Name
BRMS1 like transcriptional repressorprovided by HGNC
Primary source
HGNC:HGNC:20512
See related
Ensembl:ENSG00000100916 MIM:618514; AllianceGenome:HGNC:20512
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p40; BRMS1
Summary
The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor (BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a component of the mSin3a family of histone deacetylase complexes (HDAC). [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 7.3), adrenal (RPKM 4.6) and 24 other tissues See more
Orthologs
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Genomic context

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See BRMS1L in Genome Data Viewer
Location:
14q13.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (35826338..35871963)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (30014073..30059698)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (36295544..36341169)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene Ral GTPase activating protein catalytic subunit alpha 1 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:36278151-36278711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:36288541-36289042 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5681 Neighboring gene nuclear transport factor 2 pseudogene 2 Neighboring gene EWS RNA binding protein 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5682 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:36416980-36418179 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:36445302-36445956 Neighboring gene uncharacterized LOC105370452 Neighboring gene interleukin enhancer binding factor 2 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10. Gong C, et al. Nat Commun, 2014 Nov 19. PMID 25406648
  2. Decreased BRMS1L expression is correlated with glioma grade and predicts poor survival in glioblastoma via an invasive phenotype. Lv J, et al. Cancer Biomark, 2018. PMID 29660900
  3. BRMS1L suppresses ovarian cancer metastasis via inhibition of the β-catenin-wnt pathway. Cao P, et al. Exp Cell Res, 2018 Oct 1. PMID 30118697
  4. Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. Nikolaev AY, et al. Biochem Biophys Res Commun, 2004 Oct 29. PMID 15451426
  5. Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex. Smith KT, et al. Mol Cell Proteomics, 2012 Dec. PMID 22984288, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC11296

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell migration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Sin3-type complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
breast cancer metastasis-suppressor 1-like protein
Names
BRMS1-homolog protein p40
BRMS1-like protein p40
breast cancer metastasis-suppressor 1 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032352.4 → NP_115728.2  breast cancer metastasis-suppressor 1-like protein

    See identical proteins and their annotated locations for NP_115728.2

    Status: REVIEWED

    Source sequence(s)
    AA836514, AL162311, BU507838
    Consensus CDS
    CCDS32066.1
    UniProtKB/Swiss-Prot
    A6NFW5, A6NH45, B2RD65, Q5PSV4, Q9BRI4
    UniProtKB/TrEMBL
    B4DLQ5
    Related
    ENSP00000216807.6, ENST00000216807.12
    Conserved Domains (1) summary
    pfam08598
    Location:61 → 177
    Sds3; Sds3-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    35826338..35871963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431806.1 → XP_047287762.1  breast cancer metastasis-suppressor 1-like protein isoform X2

  2. XM_005268128.2 → XP_005268185.1  breast cancer metastasis-suppressor 1-like protein isoform X1

    See identical proteins and their annotated locations for XP_005268185.1

    UniProtKB/TrEMBL
    B4DLQ5
    Conserved Domains (1) summary
    pfam08598
    Location:61 → 177
    Sds3; Sds3-like

  3. XM_017021705.1 → XP_016877194.1  breast cancer metastasis-suppressor 1-like protein isoform X3

    UniProtKB/TrEMBL
    B4DLQ5
    Conserved Domains (1) summary
    pfam08598
    Location:13 → 129
    Sds3; Sds3-like

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    30014073..30059698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376810.1 → XP_054232785.1  breast cancer metastasis-suppressor 1-like protein isoform X2

  2. XM_054376809.1 → XP_054232784.1  breast cancer metastasis-suppressor 1-like protein isoform X1

  3. XM_054376811.1 → XP_054232786.1  breast cancer metastasis-suppressor 1-like protein isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PSV4.2 GenPept UniProtKB/Swiss-Prot:Q5PSV4

Gene LinkOut

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