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BRMS1L BRMS1 like transcriptional repressor [ Homo sapiens (human) ]

Gene ID: 84312, updated on 25-Jan-2024

Summary

Official Symbol
BRMS1Lprovided by HGNC
Official Full Name
BRMS1 like transcriptional repressorprovided by HGNC
Primary source
HGNC:HGNC:20512
See related
Ensembl:ENSG00000100916 MIM:618514; AllianceGenome:HGNC:20512
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p40; BRMS1
Summary
The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor (BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a component of the mSin3a family of histone deacetylase complexes (HDAC). [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 7.3), adrenal (RPKM 4.6) and 24 other tissues See more
Orthologs
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Genomic context

See BRMS1L in Genome Data Viewer
Location:
14q13.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (35826338..35871963)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (30014073..30059698)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (36295544..36341169)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene Ral GTPase activating protein catalytic subunit alpha 1 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:36278151-36278711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:36288541-36289042 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5681 Neighboring gene nuclear transport factor 2 pseudogene 2 Neighboring gene EWS RNA binding protein 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5682 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:36416980-36418179 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:36445302-36445956 Neighboring gene uncharacterized LOC105370452 Neighboring gene interleukin enhancer binding factor 2 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
breast cancer metastasis-suppressor 1-like protein
Names
BRMS1-homolog protein p40
BRMS1-like protein p40
breast cancer metastasis-suppressor 1 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032352.4NP_115728.2  breast cancer metastasis-suppressor 1-like protein

    See identical proteins and their annotated locations for NP_115728.2

    Status: REVIEWED

    Source sequence(s)
    AA836514, AL162311, BU507838
    Consensus CDS
    CCDS32066.1
    UniProtKB/Swiss-Prot
    A6NFW5, A6NH45, B2RD65, Q5PSV4, Q9BRI4
    UniProtKB/TrEMBL
    B4DLQ5
    Related
    ENSP00000216807.6, ENST00000216807.12
    Conserved Domains (1) summary
    pfam08598
    Location:61177
    Sds3; Sds3-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    35826338..35871963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431806.1XP_047287762.1  breast cancer metastasis-suppressor 1-like protein isoform X2

    UniProtKB/TrEMBL
    B4DLQ5
  2. XM_005268128.2XP_005268185.1  breast cancer metastasis-suppressor 1-like protein isoform X1

    See identical proteins and their annotated locations for XP_005268185.1

    UniProtKB/TrEMBL
    B4DLQ5
    Conserved Domains (1) summary
    pfam08598
    Location:61177
    Sds3; Sds3-like
  3. XM_017021705.1XP_016877194.1  breast cancer metastasis-suppressor 1-like protein isoform X3

    UniProtKB/TrEMBL
    B4DLQ5
    Conserved Domains (1) summary
    pfam08598
    Location:13129
    Sds3; Sds3-like

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    30014073..30059698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376810.1XP_054232785.1  breast cancer metastasis-suppressor 1-like protein isoform X2

    UniProtKB/TrEMBL
    B4DLQ5
  2. XM_054376809.1XP_054232784.1  breast cancer metastasis-suppressor 1-like protein isoform X1

    UniProtKB/TrEMBL
    B4DLQ5
  3. XM_054376811.1XP_054232786.1  breast cancer metastasis-suppressor 1-like protein isoform X3

    UniProtKB/TrEMBL
    B4DLQ5