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BRMS1L BRMS1 like transcriptional repressor [ Homo sapiens (human) ]

Gene ID: 84312, updated on 23-Nov-2021

Summary

Official Symbol
BRMS1Lprovided by HGNC
Official Full Name
BRMS1 like transcriptional repressorprovided by HGNC
Primary source
HGNC:HGNC:20512
See related
Ensembl:ENSG00000100916 MIM:618514
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRMS1
Summary
The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor (BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a component of the mSin3a family of histone deacetylase complexes (HDAC). [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 7.3), adrenal (RPKM 4.6) and 24 other tissues See more
Orthologs
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Genomic context

See BRMS1L in Genome Data Viewer
Location:
14q13.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (35825596..35871963)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (36295544..36341169)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene Ral GTPase activating protein catalytic subunit alpha 1 Neighboring gene QRSL1 pseudogene 3 Neighboring gene nuclear transport factor 2 pseudogene 2 Neighboring gene EWS RNA binding protein 1 pseudogene Neighboring gene uncharacterized LOC105370452 Neighboring gene interleukin enhancer binding factor 2 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC11296

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of growth IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
breast cancer metastasis-suppressor 1-like protein
Names
BRMS1-homolog protein p40
BRMS1-like protein p40
breast cancer metastasis-suppressor 1 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032352.4NP_115728.2  breast cancer metastasis-suppressor 1-like protein

    See identical proteins and their annotated locations for NP_115728.2

    Status: REVIEWED

    Source sequence(s)
    AA836514, AL162311, BU507838
    Consensus CDS
    CCDS32066.1
    UniProtKB/Swiss-Prot
    Q5PSV4
    Related
    ENSP00000216807.6, ENST00000216807.12
    Conserved Domains (1) summary
    pfam08598
    Location:61177
    Sds3; Sds3-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    35825596..35871963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021706.1XP_016877195.1  breast cancer metastasis-suppressor 1-like protein isoform X4

  2. XM_005268128.1XP_005268185.1  breast cancer metastasis-suppressor 1-like protein isoform X1

    See identical proteins and their annotated locations for XP_005268185.1

    Conserved Domains (1) summary
    pfam08598
    Location:61177
    Sds3; Sds3-like
  3. XM_006720274.2XP_006720337.1  breast cancer metastasis-suppressor 1-like protein isoform X2

    See identical proteins and their annotated locations for XP_006720337.1

    Conserved Domains (1) summary
    pfam08598
    Location:13129
    Sds3; Sds3-like
  4. XM_006720275.2XP_006720338.1  breast cancer metastasis-suppressor 1-like protein isoform X3

    See identical proteins and their annotated locations for XP_006720338.1

    UniProtKB/Swiss-Prot
    Q5PSV4
    Conserved Domains (1) summary
    pfam08598
    Location:13129
    Sds3; Sds3-like
  5. XM_017021705.1XP_016877194.1  breast cancer metastasis-suppressor 1-like protein isoform X3

    UniProtKB/Swiss-Prot
    Q5PSV4
    Conserved Domains (1) summary
    pfam08598
    Location:13129
    Sds3; Sds3-like
  6. XM_017021704.2XP_016877193.1  breast cancer metastasis-suppressor 1-like protein isoform X3

    UniProtKB/Swiss-Prot
    Q5PSV4
    Conserved Domains (1) summary
    pfam08598
    Location:13129
    Sds3; Sds3-like
  7. XM_017021703.1XP_016877192.1  breast cancer metastasis-suppressor 1-like protein isoform X2

    Conserved Domains (1) summary
    pfam08598
    Location:13129
    Sds3; Sds3-like
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