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Brms1l breast cancer metastasis-suppressor 1-like [ Mus musculus (house mouse) ]

Gene ID: 52592, updated on 30-Apr-2024

Summary

Official Symbol
Brms1lprovided by MGI
Official Full Name
breast cancer metastasis-suppressor 1-likeprovided by MGI
Primary source
MGI:MGI:1196337
See related
Ensembl:ENSMUSG00000012076 AllianceGenome:MGI:1196337
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BRMS1; D12Ertd407e; 0710008O11Rik
Summary
Predicted to enable histone deacetylase binding activity. Predicted to be involved in histone deacetylation and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of growth. Predicted to be located in nucleus. Predicted to be part of Sin3-type complex. Orthologous to human BRMS1L (BRMS1 like transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 23.2), frontal lobe adult (RPKM 20.6) and 24 other tissues See more
Orthologs
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Genomic context

See Brms1l in Genome Data Viewer
Location:
12 C1; 12 24.18 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55883109..55916521)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55836324..55869736)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene Ral GTPase activating protein, alpha subunit 1 Neighboring gene insulinoma-associated 2 Neighboring gene STARR-seq mESC enhancer starr_32196 Neighboring gene STARR-seq mESC enhancer starr_32197 Neighboring gene STARR-positive B cell enhancer ABC_E11776 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:56937027-56937210 Neighboring gene STARR-seq mESC enhancer starr_32198 Neighboring gene predicted gene, 22296 Neighboring gene predicted gene, 53722

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General protein information

Preferred Names
breast cancer metastasis-suppressor 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037756.3NP_001032845.1  breast cancer metastasis-suppressor 1-like protein

    See identical proteins and their annotated locations for NP_001032845.1

    Status: VALIDATED

    Source sequence(s)
    AK155742, BC034885
    Consensus CDS
    CCDS36453.1
    UniProtKB/Swiss-Prot
    Q3U1T3, Q8JZX8
    Related
    ENSMUSP00000082500.5, ENSMUST00000059250.8
    Conserved Domains (1) summary
    pfam08598
    Location:61179
    Sds3; Sds3-like

RNA

  1. NR_155205.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159624, CR974464

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    55883109..55916521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_381530.4 RNA Sequence

  2. XR_004937525.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027867.2: Suppressed sequence

    Description
    NM_027867.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.