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EEA1 early endosome antigen 1 [ Homo sapiens (human) ]

Gene ID: 8411, updated on 17-Jun-2019

Summary

Official Symbol
EEA1provided by HGNC
Official Full Name
early endosome antigen 1provided by HGNC
Primary source
HGNC:HGNC:3185
See related
Ensembl:ENSG00000102189 MIM:605070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MST105; ZFYVE2; MSTP105
Expression
Ubiquitous expression in esophagus (RPKM 9.9), fat (RPKM 8.8) and 25 other tissues See more
Orthologs

Genomic context

See EEA1 in Genome Data Viewer
Location:
12q22
Exon count:
32
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (92770637..92975228, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (93166285..93323107, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369905 Neighboring gene chromosome 12 open reading frame 74 Neighboring gene pleckstrin homology and RhoGEF domain containing G7 Neighboring gene s-adenosylmethionine synthase isoform type-2-like Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 50 Neighboring gene RNA, U6 small nuclear 1329, pseudogene Neighboring gene long intergenic non-protein coding RNA 2413 Neighboring gene developmental pluripotency associated 3 pseudogene Neighboring gene uncharacterized LOC643339

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 co-localizes with EEA-1 in human plasmacytoid dendritic cells PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 Env co-localizes with EEA1 in early endosomes PubMed
Pr55(Gag) gag HIV-1 Gag and viral RNA co-localize with EEA1 in early endosomes PubMed
gag Myristoylated Gag co-localizes with EEA1 in early endosomes PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of early endosome antigen 1 (EEA1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
Vpu vpu Expression of HIV-1 Vpu induces co-localization of tetherin with early endosome protein EEA-1 or late endosome protein LAMP-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin binding NAS
Non-traceable Author Statement
more info
PubMed 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
early endosome to late endosome transport NAS
Non-traceable Author Statement
more info
PubMed 
endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic vesicle to endosome fusion TAS
Traceable Author Statement
more info
PubMed 
vesicle fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral RNA genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axonal spine IEA
Inferred from Electronic Annotation
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extrinsic component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
recycling endosome IEA
Inferred from Electronic Annotation
more info
 
serine-pyruvate aminotransferase complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
early endosome antigen 1
Names
early endosome antigen 1, 162kD
early endosome-associated protein
endosome-associated protein p162
zinc finger FYVE domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003566.4NP_003557.3  early endosome antigen 1

    Status: VALIDATED

    Source sequence(s)
    AC016136, AC021646, AC026111
    Consensus CDS
    CCDS31874.1
    Related
    ENSP00000317955.8, ENST00000322349.12

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    92770637..92975228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020018.1XP_016875507.1  early endosome antigen 1 isoform X2

  2. XM_011538814.2XP_011537116.1  early endosome antigen 1 isoform X1

    Conserved Domains (3) summary
    cd15730
    Location:13891451
    FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
    pfam01576
    Location:3081382
    Myosin_tail_1; Myosin tail
    cl19219
    Location:425519
    DUF342; Protein of unknown function (DUF342)
  3. XM_011538815.2XP_011537117.1  early endosome antigen 1 isoform X3

    Conserved Domains (3) summary
    cd15730
    Location:13011363
    FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
    pfam01576
    Location:2201294
    Myosin_tail_1; Myosin tail
    cl19219
    Location:337431
    DUF342; Protein of unknown function (DUF342)
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