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Eea1 early endosome antigen 1 [ Mus musculus (house mouse) ]

Gene ID: 216238, updated on 9-May-2024

Summary

Official Symbol
Eea1provided by MGI
Official Full Name
early endosome antigen 1provided by MGI
Primary source
MGI:MGI:2442192
See related
Ensembl:ENSMUSG00000036499 AllianceGenome:MGI:2442192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZFYVE2; A430109M19Rik; B230358H09Rik
Summary
Predicted to enable 1-phosphatidylinositol binding activity; GTP-dependent protein binding activity; and protein homodimerization activity. Predicted to be involved in endocytosis; vesicle fusion; and viral RNA genome replication. Located in axonal spine and early endosome. Part of serine-pyruvate aminotransferase complex. Is expressed in cerebellum Purkinje cell layer; genitourinary system; and pancreatic acinus. Orthologous to human EEA1 (early endosome antigen 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 5.5), placenta adult (RPKM 5.0) and 27 other tissues See more
Orthologs
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Genomic context

See Eea1 in Genome Data Viewer
Location:
10 C2; 10 49.59 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (95776525..95881380)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (95940663..96045518)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33377 Neighboring gene predicted gene, 33543 Neighboring gene STARR-positive B cell enhancer ABC_E2335 Neighboring gene STARR-seq mESC enhancer starr_27659 Neighboring gene STARR-seq mESC enhancer starr_27660 Neighboring gene STARR-seq mESC enhancer starr_27661 Neighboring gene STARR-seq mESC enhancer starr_27662 Neighboring gene STARR-positive B cell enhancer ABC_E2962 Neighboring gene predicted gene, 24433 Neighboring gene STARR-seq mESC enhancer starr_27664 Neighboring gene predicted gene, 49817 Neighboring gene STARR-seq mESC enhancer starr_27665 Neighboring gene STARR-seq mESC enhancer starr_27666 Neighboring gene STARR-seq mESC enhancer starr_27667 Neighboring gene predicted gene, 48425

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 1-phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in chemical synaptic transmission, postsynaptic IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation by host of viral process ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle fusion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in axonal spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 
part_of serine-pyruvate aminotransferase complex IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001932.3NP_001001932.1  early endosome antigen 1

    See identical proteins and their annotated locations for NP_001001932.1

    Status: VALIDATED

    Source sequence(s)
    AC115970, BB638838, BC075637
    Consensus CDS
    CCDS36042.1
    UniProtKB/Swiss-Prot
    Q6DIC2, Q8BL66
    Related
    ENSMUSP00000061493.7, ENSMUST00000053484.8
    Conserved Domains (3) summary
    cd15730
    Location:13471409
    FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
    pfam01576
    Location:1071119
    Myosin_tail_1; Myosin tail
    pfam07851
    Location:909988
    TMPIT; TMPIT-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    95776525..95881380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513522.5XP_006513585.1  early endosome antigen 1 isoform X1

    Conserved Domains (3) summary
    COG1196
    Location:5041346
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:130794
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15730
    Location:13941456
    FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
  2. XM_006513523.5XP_006513586.1  early endosome antigen 1 isoform X2

    Conserved Domains (3) summary
    COG1196
    Location:4991341
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:130789
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15730
    Location:13891451
    FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
  3. XM_006513524.5XP_006513587.1  early endosome antigen 1 isoform X3

    Conserved Domains (3) summary
    COG1196
    Location:4621304
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:88752
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15730
    Location:13521414
    FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
  4. XM_006513525.5XP_006513588.1  early endosome antigen 1 isoform X4

    Conserved Domains (3) summary
    COG1196
    Location:3421184
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:19622
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15730
    Location:12321294
    FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins