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ULK1 unc-51 like autophagy activating kinase 1 [ Homo sapiens (human) ]

Gene ID: 8408, updated on 9-Jan-2022

Summary

Official Symbol
ULK1provided by HGNC
Official Full Name
unc-51 like autophagy activating kinase 1provided by HGNC
Primary source
HGNC:HGNC:12558
See related
Ensembl:ENSG00000177169 MIM:603168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATG1; ATG1A; UNC51; hATG1; Unc51.1
Summary
Enables identical protein binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including autophagosome assembly; positive regulation by symbiont of host autophagy; and protein phosphorylation. Located in autophagosome; cytosol; and phagophore assembly site membrane. Is extrinsic component of autophagosome membrane; extrinsic component of omegasome membrane; and extrinsic component of phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in bone marrow (RPKM 14.9), endometrium (RPKM 11.7) and 25 other tissues See more
Orthologs
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Genomic context

See ULK1 in Genome Data Viewer
Location:
12q24.33
Exon count:
28
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (131894622..131923150)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (132379167..132407695)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 17 Neighboring gene Sharpr-MPRA regulatory region 458 Neighboring gene uncharacterized LOC107984455 Neighboring gene pseudouridine synthase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef downregulates the mRNA expression of ULK1 in human mesenchymal stem cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38455, FLJ46475

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in autophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in axon extension IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in late nucleophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in macroautophagy TAS
Traceable Author Statement
more info
 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of collateral sprouting IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of autophagosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein lipidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Atg1/ULK1 kinase complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in extrinsic component of autophagosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extrinsic component of omegasome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extrinsic component of phagophore assembly site membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in phagophore assembly site membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase ULK1
Names
ATG1 autophagy related 1 homolog
autophagy-related protein 1 homolog
NP_003556.2
XP_011537100.1
XP_011537101.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003565.4NP_003556.2  serine/threonine-protein kinase ULK1

    Status: VALIDATED

    Source sequence(s)
    AC131009
    Consensus CDS
    CCDS9274.1
    Related
    ENSP00000324560.3, ENST00000321867.6
    Conserved Domains (2) summary
    cd14202
    Location:13279
    STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
    pfam12063
    Location:8781044
    DUF3543; Domain of unknown function (DUF3543)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    131894622..131923150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538798.3XP_011537100.1  serine/threonine-protein kinase ULK1 isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:16278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14202
    Location:13279
    STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
    pfam12063
    Location:8601067
    DUF3543; Domain of unknown function (DUF3543)
  2. XM_011538799.2XP_011537101.1  serine/threonine-protein kinase ULK1 isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:16278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14202
    Location:13279
    STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
    pfam12063
    Location:8311038
    DUF3543; Domain of unknown function (DUF3543)

RNA

  1. XR_001748883.2 RNA Sequence

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