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ULK1 unc-51 like autophagy activating kinase 1 [ Homo sapiens (human) ]

Gene ID: 8408, updated on 27-Nov-2024

Summary

Official Symbol
ULK1provided by HGNC
Official Full Name
unc-51 like autophagy activating kinase 1provided by HGNC
Primary source
HGNC:HGNC:12558
See related
Ensembl:ENSG00000177169 MIM:603168; AllianceGenome:HGNC:12558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATG1; ATG1A; UNC51; hATG1; Unc51.1
Summary
Enables identical protein binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including protein phosphorylation; regulation of autophagy; and regulation of protein lipidation. Located in bounding membrane of organelle; cytosol; and phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex and phagophore assembly site. Is active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 14.9), endometrium (RPKM 11.7) and 25 other tissues See more
Orthologs
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Genomic context

See ULK1 in Genome Data Viewer
Location:
12q24.33
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (131894622..131923150)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (131939343..131971098)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (132379167..132407695)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903058 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:132347237-132347900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:132348565-132349228 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:132352369-132352965 Neighboring gene uncharacterized LOC124903059 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5102 Neighboring gene Sharpr-MPRA regulatory region 8404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:132381351-132382148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:132384711-132385228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:132385229-132385746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:132385901-132386674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:132386675-132387447 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7371 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7373 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:132409300-132410176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5106 Neighboring gene PUS1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5107 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25941 Neighboring gene pseudouridine synthase 1 Neighboring gene Sharpr-MPRA regulatory region 9670

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef downregulates the mRNA expression of ULK1 in human mesenchymal stem cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ38455, FLJ46475

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in autophagosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in autophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in axon extension IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in macroautophagy TAS
Traceable Author Statement
more info
 
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of collateral sprouting IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of autophagosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein lipidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
involved_in response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Atg1/ULK1 kinase complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in autophagosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IC
Inferred by Curator
more info
PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
located_in omegasome membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in phagophore assembly site membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase ULK1
Names
ATG1 autophagy related 1 homolog
autophagy-related protein 1 homolog
NP_003556.2
XP_011537100.1
XP_011537101.1
XP_054229379.1
XP_054229380.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003565.4NP_003556.2  serine/threonine-protein kinase ULK1

    Status: VALIDATED

    Source sequence(s)
    AC131009
    Consensus CDS
    CCDS9274.1
    UniProtKB/Swiss-Prot
    O75385, Q9UQ28
    Related
    ENSP00000324560.3, ENST00000321867.6
    Conserved Domains (2) summary
    cd14202
    Location:13279
    STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
    pfam12063
    Location:8781044
    DUF3543; Domain of unknown function (DUF3543)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    131894622..131923150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538798.4XP_011537100.1  serine/threonine-protein kinase ULK1 isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:16278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14202
    Location:13279
    STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
    pfam12063
    Location:8601067
    DUF3543; Domain of unknown function (DUF3543)
  2. XM_011538799.3XP_011537101.1  serine/threonine-protein kinase ULK1 isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:16278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14202
    Location:13279
    STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
    pfam12063
    Location:8311038
    DUF3543; Domain of unknown function (DUF3543)

RNA

  1. XR_007063134.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    131939343..131971098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373404.1XP_054229379.1  serine/threonine-protein kinase ULK1 isoform X1

  2. XM_054373405.1XP_054229380.1  serine/threonine-protein kinase ULK1 isoform X2

RNA

  1. XR_008488691.1 RNA Sequence