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ULK1 unc-51 like autophagy activating kinase 1 [ Homo sapiens (human) ]

Gene ID: 8408, updated on 15-Jun-2019

Summary

Official Symbol
ULK1provided by HGNC
Official Full Name
unc-51 like autophagy activating kinase 1provided by HGNC
Primary source
HGNC:HGNC:12558
See related
Ensembl:ENSG00000177169 MIM:603168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATG1; ATG1A; UNC51; hATG1; Unc51.1
Expression
Ubiquitous expression in bone marrow (RPKM 14.9), endometrium (RPKM 11.7) and 25 other tissues See more
Orthologs

Genomic context

See ULK1 in Genome Data Viewer
Location:
12q24.33
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (131894734..131923162)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (132379279..132407707)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370088 Neighboring gene matrix metallopeptidase 17 Neighboring gene uncharacterized LOC107984455 Neighboring gene pseudouridine synthase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef downregulates the mRNA expression of ULK1 in human mesenchymal stem cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Autophagy - animal, organism-specific biosystem (from KEGG)
    Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - animal, conserved biosystem (from KEGG)
    Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Longevity regulating pathway, organism-specific biosystem (from KEGG)
    Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
  • Macroautophagy, organism-specific biosystem (from REACTOME)
    Macroautophagy, organism-specific biosystemMacroautophagy (hereafter referred to as autophagy) acts as a buffer against starvation by liberating building materials and energy sources from cellular components. It has additional roles in embryo...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Mitophagy - animal, organism-specific biosystem (from KEGG)
    Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Mitophagy - animal, conserved biosystem (from KEGG)
    Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Nanoparticle triggered autophagic cell death, organism-specific biosystem (from WikiPathways)
    Nanoparticle triggered autophagic cell death, organism-specific biosystemProgrammed cell death: autophagic cell death. Autophagy (self-eating) is a survival mechanism deployed by cells to cope with conditions of nutrient deprivation. However, unrestrained autophagy can re...
  • PI3K-AKT-mTOR signaling pathway and therapeutic opportunities, organism-specific biosystem (from WikiPathways)
    PI3K-AKT-mTOR signaling pathway and therapeutic opportunities, organism-specific biosystemThis pathway is based on figure 1 from Merritt et al. (See Bibliography). The PI3K-AKT-mTOR signaling pathway has been shown to have a significant correlation with the development of castration-resis...
  • RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystem (from REACTOME)
    RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystemHuman cells have more than 60 RAB proteins that are key regulators of intracellular membrane trafficking. These small GTPases contribute to trafficking specificity by localizing to the membranes of d...
  • Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
    Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
  • TBC/RABGAPs, organism-specific biosystem (from REACTOME)
    TBC/RABGAPs, organism-specific biosystemRab GTPases are peripheral membrane proteins involved in membrane trafficking. Often through their indirect interactions with coat components, motors, tethering factors and SNAREs, the Rab GTPases se...
  • Target Of Rapamycin (TOR) Signaling, organism-specific biosystem (from WikiPathways)
    Target Of Rapamycin (TOR) Signaling, organism-specific biosystemTOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central r...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
  • mTOR signaling pathway, organism-specific biosystem (from KEGG)
    mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
  • mTOR signaling pathway, conserved biosystem (from KEGG)
    mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38455, FLJ46475

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Rab GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagy IDA
Inferred from Direct Assay
more info
PubMed 
autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
autophagy of host cells involved in interaction with symbiont IGI
Inferred from Genetic Interaction
more info
PubMed 
axon extension IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
 
macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
macroautophagy TAS
Traceable Author Statement
more info
 
negative regulation of protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection regeneration IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of autophagosome assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of macroautophagy TAS
Traceable Author Statement
more info
 
response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Atg1/ULK1 kinase complex IPI
Inferred from Physical Interaction
more info
PubMed 
autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
axon IEA
Inferred from Electronic Annotation
more info
 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extrinsic component of autophagosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of omegasome membrane IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of phagophore assembly site membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with guanyl-nucleotide exchange factor complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagophore assembly site membrane IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase ULK1
Names
ATG1 autophagy related 1 homolog
autophagy-related protein 1 homolog
NP_003556.1
XP_011537100.1
XP_011537101.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003565.3NP_003556.1  serine/threonine-protein kinase ULK1

    See identical proteins and their annotated locations for NP_003556.1

    Status: VALIDATED

    Source sequence(s)
    AB018265, AC131009, AF045458, BI822269, BU729635, CF131673
    Consensus CDS
    CCDS9274.1
    UniProtKB/Swiss-Prot
    O75385
    Related
    ENSP00000324560.3, ENST00000321867.6
    Conserved Domains (3) summary
    smart00220
    Location:16278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14202
    Location:13279
    STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
    pfam12063
    Location:8371044
    DUF3543; Domain of unknown function (DUF3543)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    131894622..131923150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538798.3XP_011537100.1  serine/threonine-protein kinase ULK1 isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:16278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14202
    Location:13279
    STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
    pfam12063
    Location:8601067
    DUF3543; Domain of unknown function (DUF3543)
  2. XM_011538799.2XP_011537101.1  serine/threonine-protein kinase ULK1 isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:16278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14202
    Location:13279
    STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
    pfam12063
    Location:8311038
    DUF3543; Domain of unknown function (DUF3543)

RNA

  1. XR_001748883.2 RNA Sequence

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