Format

Send to:

Choose Destination

MND1 meiotic nuclear divisions 1 [ Homo sapiens (human) ]

Gene ID: 84057, updated on 28-Jun-2020

Summary

Official Symbol
MND1provided by HGNC
Official Full Name
meiotic nuclear divisions 1provided by HGNC
Primary source
HGNC:HGNC:24839
See related
Ensembl:ENSG00000121211 MIM:611422
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAJ
Summary
The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 3.9), lymph node (RPKM 2.6) and 15 other tissues See more
Orthologs

Genomic context

See MND1 in Genome Data Viewer
Location:
4q31.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (153344649..153415118)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (154265801..154336247)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 2 Neighboring gene RNA, U6 small nuclear 1196, pseudogene Neighboring gene annexin A2 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 419, pseudogene Neighboring gene transmembrane 131 like Neighboring gene uncharacterized LOC105377498 Neighboring gene toll like receptor 2 pseudogene Neighboring gene WD repeat domain 45 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of meiotic nuclear divisions 1 homolog (MND1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
meiotic nuclear division protein 1 homolog
Names
homolog of yeast MND1
meiotic nuclear divisions 1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253861.1NP_001240790.1  meiotic nuclear division protein 1 homolog isoform 2

    See identical proteins and their annotated locations for NP_001240790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA542845, BG613292, BM820228, BU533354
    Consensus CDS
    CCDS75202.1
    UniProtKB/TrEMBL
    A0A087WTC6
    Related
    ENSP00000477758.1, ENST00000622785.4
    Conserved Domains (1) summary
    pfam03962
    Location:17119
    Mnd1; Mnd1 family
  2. NM_032117.4NP_115493.1  meiotic nuclear division protein 1 homolog isoform 1

    See identical proteins and their annotated locations for NP_115493.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA542845, AC013477, AK312172, BM820228, BU533354
    Consensus CDS
    CCDS3782.1
    UniProtKB/Swiss-Prot
    Q9BWT6
    Related
    ENSP00000240488.3, ENST00000240488.8
    Conserved Domains (1) summary
    pfam03962
    Location:17202
    Mnd1; Mnd1 family

RNA

  1. NR_045605.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes two alternate internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA542845, AC013477, BF975093, BG758047, BU533354

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    153344649..153415118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263275.2XP_005263332.1  meiotic nuclear division protein 1 homolog isoform X2

    See identical proteins and their annotated locations for XP_005263332.1

    Conserved Domains (2) summary
    COG5124
    Location:5189
    COG5124; Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only]
    pfam03962
    Location:16187
    Mnd1; Mnd1 family
  2. XM_024454242.1XP_024310010.1  meiotic nuclear division protein 1 homolog isoform X3

    Conserved Domains (1) summary
    pfam03962
    Location:2172
    Mnd1; Mnd1 family
  3. XM_017008688.2XP_016864177.1  meiotic nuclear division protein 1 homolog isoform X1

Support Center