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ZNF484 zinc finger protein 484 [ Homo sapiens (human) ]

Gene ID: 83744, updated on 23-Nov-2021

Summary

Official Symbol
ZNF484provided by HGNC
Official Full Name
zinc finger protein 484provided by HGNC
Primary source
HGNC:HGNC:23385
See related
Ensembl:ENSG00000127081
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BA526D8.4
Expression
Ubiquitous expression in testis (RPKM 2.5), brain (RPKM 1.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF484 in Genome Data Viewer
Location:
9q22.31
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (92844182..92878060, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95606464..95640320, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 19, pseudogene Neighboring gene zinc finger protein 41 pseudogene Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 2 Neighboring gene SPATA31 subfamily A pseudogene Neighboring gene sorting nexin 18 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC133033, MGC133034

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 484
Names
KRAB box containing C2H2 type zinc finger bA526D8.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007101.4NP_001007102.1  zinc finger protein 484 isoform b

    See identical proteins and their annotated locations for NP_001007102.1

    Status: VALIDATED

    Source sequence(s)
    AL136981
    Consensus CDS
    CCDS35067.1
    UniProtKB/Swiss-Prot
    Q5JVG2
    Related
    ENSP00000364646.3, ENST00000332591.6
    Conserved Domains (3) summary
    COG5048
    Location:374775
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:658678
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:131
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  2. NM_001261458.3NP_001248387.1  zinc finger protein 484 isoform c

    See identical proteins and their annotated locations for NP_001248387.1

    Status: VALIDATED

    Source sequence(s)
    AL136981
    Consensus CDS
    CCDS59136.1
    UniProtKB/Swiss-Prot
    Q5JVG2
    Related
    ENSP00000378881.3, ENST00000395505.6
    Conserved Domains (6) summary
    smart00349
    Location:1069
    KRAB; krueppel associated box
    COG5048
    Location:412813
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:696716
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:722744
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1049
    KRAB; KRAB box
    pfam13465
    Location:736759
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001261459.3NP_001248388.1  zinc finger protein 484 isoform b

    See identical proteins and their annotated locations for NP_001248388.1

    Status: VALIDATED

    Source sequence(s)
    AL136981
    Consensus CDS
    CCDS35067.1
    UniProtKB/Swiss-Prot
    Q5JVG2
    Related
    ENSP00000378882.4, ENST00000395506.7
    Conserved Domains (3) summary
    COG5048
    Location:374775
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:658678
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:131
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  4. NM_001261460.3NP_001248389.1  zinc finger protein 484 isoform b

    See identical proteins and their annotated locations for NP_001248389.1

    Status: VALIDATED

    Source sequence(s)
    AL136981
    Consensus CDS
    CCDS35067.1
    UniProtKB/Swiss-Prot
    Q5JVG2
    Conserved Domains (3) summary
    COG5048
    Location:374775
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:658678
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:131
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  5. NM_001354536.2NP_001341465.1  zinc finger protein 484 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL136981
    Consensus CDS
    CCDS35067.1
    Conserved Domains (3) summary
    COG5048
    Location:374775
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:658678
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:131
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  6. NM_001354537.2NP_001341466.1  zinc finger protein 484 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL136981
    Conserved Domains (4) summary
    smart00349
    Location:2584
    KRAB; krueppel associated box
    COG5048
    Location:427828
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:711731
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:387412
    zf-H2C2_2; Zinc-finger double domain
  7. NM_031486.4NP_113674.1  zinc finger protein 484 isoform a

    See identical proteins and their annotated locations for NP_113674.1

    Status: VALIDATED

    Source sequence(s)
    AL136981
    Consensus CDS
    CCDS35066.1
    UniProtKB/Swiss-Prot
    Q5JVG2
    Related
    ENSP00000364645.3, ENST00000375495.8
    Conserved Domains (3) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:410811
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:694714
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    92844182..92878060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519073.2XP_011517375.1  zinc finger protein 484 isoform X1

    Conserved Domains (6) summary
    smart00349
    Location:2584
    KRAB; krueppel associated box
    COG5048
    Location:442843
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:726746
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:752774
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2564
    KRAB; KRAB box
    pfam13465
    Location:766789
    zf-H2C2_2; Zinc-finger double domain
  2. XM_006717299.3XP_006717362.1  zinc finger protein 484 isoform X4

    See identical proteins and their annotated locations for XP_006717362.1

    Conserved Domains (5) summary
    smart00349
    Location:131
    KRAB; krueppel associated box
    COG5048
    Location:389790
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:673693
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:699721
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:713736
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011519075.2XP_011517377.1  zinc finger protein 484 isoform X3

    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:425826
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:709729
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:735757
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:749772
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017015178.1XP_016870667.1  zinc finger protein 484 isoform X4

    Conserved Domains (5) summary
    smart00349
    Location:131
    KRAB; krueppel associated box
    COG5048
    Location:389790
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:673693
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:699721
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:713736
    zf-H2C2_2; Zinc-finger double domain
  5. XM_017015181.1XP_016870670.1  zinc finger protein 484 isoform X5

    UniProtKB/Swiss-Prot
    Q5JVG2
    Conserved Domains (3) summary
    COG5048
    Location:374775
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:658678
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:131
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  6. XM_011519074.2XP_011517376.1  zinc finger protein 484 isoform X2

    Conserved Domains (6) summary
    smart00349
    Location:1069
    KRAB; krueppel associated box
    COG5048
    Location:427828
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:711731
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:737759
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1049
    KRAB; KRAB box
    pfam13465
    Location:751774
    zf-H2C2_2; Zinc-finger double domain
  7. XM_017015179.1XP_016870668.1  zinc finger protein 484 isoform X4

    Conserved Domains (5) summary
    smart00349
    Location:131
    KRAB; krueppel associated box
    COG5048
    Location:389790
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:673693
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:699721
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:713736
    zf-H2C2_2; Zinc-finger double domain
  8. XM_017015180.1XP_016870669.1  zinc finger protein 484 isoform X4

    Conserved Domains (5) summary
    smart00349
    Location:131
    KRAB; krueppel associated box
    COG5048
    Location:389790
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:673693
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:699721
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:713736
    zf-H2C2_2; Zinc-finger double domain
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