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H3C11 H3 clustered histone 11 [ Homo sapiens (human) ]

Gene ID: 8354, updated on 22-Sep-2022


Official Symbol
H3C11provided by HGNC
Official Full Name
H3 clustered histone 11provided by HGNC
Primary source
See related
Ensembl:ENSG00000275379 MIM:602814; AllianceGenome:HGNC:4771
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H3.f; H3/f; H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3FF; H3C10; H3C12; HIST1H3I
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
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Genomic context

See H3C11 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (27871845..27872346, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (27741516..27742017, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (27839623..27840124, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H2A clustered histone 16 Neighboring gene H1.5 linker histone, cluster member Neighboring gene H4 clustered histone 13 Neighboring gene HLA complex group 13 pseudogene

Genomic regions, transcripts, and products

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
involved_in epigenetic regulation of gene expression IDA
Inferred from Direct Assay
more info
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
involved_in nucleosome assembly IMP
Inferred from Mutant Phenotype
more info
involved_in telomere organization TAS
Traceable Author Statement
more info

General protein information

Preferred Names
histone H3.1
H3 histone family, member F
histone 1, H3i
histone H3/f
histone cluster 1 H3 family member i
histone cluster 1, H3i

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003533.3NP_003524.1  histone H3.1

    See identical proteins and their annotated locations for NP_003524.1

    Status: REVIEWED

    Source sequence(s)
    Consensus CDS
    P68431, Q93081
    ENSP00000483283.2, ENST00000616365.2
    Conserved Domains (1) summary
    PTZ00018; histone H3; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    27871845..27872346 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060930.1 Alternate T2T-CHM13v2.0

    27741516..27742017 complement
    GenBank, FASTA, Sequence Viewer (Graphics)