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H2BC7 H2B clustered histone 7 [ Homo sapiens (human) ]

Gene ID: 8343, updated on 7-Sep-2023


Official Symbol
H2BC7provided by HGNC
Official Full Name
H2B clustered histone 7provided by HGNC
Primary source
See related
Ensembl:ENSG00000277224 MIM:602804; AllianceGenome:HGNC:4752
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2B/g; H2BC4; H2BC6; H2BC8; H2BFG; H2BC10; HIST1H2BF
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. The protein has antibacterial and antifungal antimicrobial activity. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
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Genomic context

See H2BC7 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26199516..26199988)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (26067982..26068454)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26199744..26200216)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H1.12 linker histone, cluster member, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26196641-26197242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26197243-26197843 Neighboring gene H3 clustered histone 4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:26199013-26200212 Neighboring gene H2A clustered histone 7 Neighboring gene ribosomal protein S10 pseudogene 1 Neighboring gene H4 clustered histone 5

Genomic regions, transcripts, and products


EBI GWAS Catalog

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
enables identical protein binding IPI
Inferred from Physical Interaction
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
located_in extracellular exosome HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
located_in nucleoplasm TAS
Traceable Author Statement
more info
part_of nucleosome NAS
Non-traceable Author Statement
more info
located_in nucleus HDA PubMed 

General protein information

Preferred Names
histone H2B type 1-C/E/F/G/I
H2B histone family, member G
histone 1, H2bf
histone H2B.1 A
histone H2B.g
histone cluster 1 H2B family member f
histone cluster 1, H2bf

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003522.4NP_003513.1  histone H2B type 1-C/E/F/G/I

    See identical proteins and their annotated locations for NP_003513.1

    Status: REVIEWED

    Source sequence(s)
    Consensus CDS
    P02278, P62807, Q3B872, Q4VB69, Q93078, Q93080
    B2R4S9, Q0D2M2
    ENSP00000348924.3, ENST00000356530.6
    Conserved Domains (1) summary
    H2B; Histone H2B

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060930.1 Alternate T2T-CHM13v2.0

    GenBank, FASTA, Sequence Viewer (Graphics)