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Tfap4 transcription factor AP4 [ Mus musculus (house mouse) ]

Gene ID: 83383, updated on 5-Jan-2023

Summary

Official Symbol
Tfap4provided by MGI
Official Full Name
transcription factor AP4provided by MGI
Primary source
MGI:MGI:103239
See related
Ensembl:ENSMUSG00000005718 AllianceGenome:MGI:103239
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AP-4; Tcfap4; bHLHc41; D930048N17Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and histone deacetylase binding activity. Involved in cellular response to dexamethasone stimulus; negative regulation of macromolecule metabolic process; and protein-containing complex assembly. Acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription repressor complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and gut. Orthologous to human TFAP4 (transcription factor AP-4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 3.3), CNS E11.5 (RPKM 2.6) and 28 other tissues See more
Orthologs
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Genomic context

See Tfap4 in Genome Data Viewer
Location:
16 A1; 16 2.45 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4362525..4378625, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4544661..4560762, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 9 Neighboring gene tubulin cofactor a pseudogene Neighboring gene sarcalumenin Neighboring gene RIKEN cDNA D330022H12 gene Neighboring gene GLIS family zinc finger 2 Neighboring gene presequence translocase-asssociated motor 16

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
enables E-box binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to dexamethasone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription repressor complex IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
transcription factor AP-4
Names
transcription factor AP-4 (activating enhancer-binding protein 4)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031182.2NP_112459.1  transcription factor AP-4

    See identical proteins and their annotated locations for NP_112459.1

    Status: PROVISIONAL

    Source sequence(s)
    AC157597
    Consensus CDS
    CCDS27919.1
    UniProtKB/TrEMBL
    A0A8C6N2X6, Q9JIZ5
    Related
    ENSMUSP00000005862.8, ENSMUST00000005862.9
    Conserved Domains (1) summary
    pfam00010
    Location:49100
    HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    4362525..4378625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522766.5XP_006522829.1  transcription factor AP-4 isoform X2

    See identical proteins and their annotated locations for XP_006522829.1

    Conserved Domains (1) summary
    cl00081
    Location:146
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  2. XM_006522762.4XP_006522825.1  transcription factor AP-4 isoform X2

    See identical proteins and their annotated locations for XP_006522825.1

    Conserved Domains (1) summary
    cl00081
    Location:146
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  3. XM_030249341.1XP_030105201.1  transcription factor AP-4 isoform X2

    Conserved Domains (1) summary
    cl00081
    Location:146
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  4. XM_006522764.5XP_006522827.1  transcription factor AP-4 isoform X2

    See identical proteins and their annotated locations for XP_006522827.1

    Conserved Domains (1) summary
    cl00081
    Location:146
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  5. XM_006522765.4XP_006522828.1  transcription factor AP-4 isoform X2

    See identical proteins and their annotated locations for XP_006522828.1

    Conserved Domains (1) summary
    cl00081
    Location:146
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  6. XM_011246047.3XP_011244349.1  transcription factor AP-4 isoform X2

    See identical proteins and their annotated locations for XP_011244349.1

    Conserved Domains (1) summary
    cl00081
    Location:146
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  7. XM_030249340.1XP_030105200.1  transcription factor AP-4 isoform X2

    Conserved Domains (1) summary
    cl00081
    Location:146
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  8. XM_006522763.5XP_006522826.1  transcription factor AP-4 isoform X2

    See identical proteins and their annotated locations for XP_006522826.1

    Conserved Domains (1) summary
    cl00081
    Location:146
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  9. XM_017317166.3XP_017172655.1  transcription factor AP-4 isoform X1

    Conserved Domains (1) summary
    cd11419
    Location:2686
    bHLHzip_TFAP4; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins