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TFAP4 transcription factor AP-4 [ Homo sapiens (human) ]

Gene ID: 7023, updated on 1-Aug-2020

Summary

Official Symbol
TFAP4provided by HGNC
Official Full Name
transcription factor AP-4provided by HGNC
Primary source
HGNC:HGNC:11745
See related
Ensembl:ENSG00000090447 MIM:600743
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AP-4; bHLHc41
Summary
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]
Expression
Ubiquitous expression in ovary (RPKM 4.0), spleen (RPKM 3.0) and 25 other tissues See more
Orthologs

Genomic context

See TFAP4 in Genome Data Viewer
Location:
16p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (4257186..4273023, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4307187..4323001, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1569 Neighboring gene putative uncharacterized protein encoded by LINC00596 Neighboring gene GLIS family zinc finger 2 Neighboring gene GLIS2 antisense RNA 1 Neighboring gene CORO7-PAM16 readthrough Neighboring gene presequence translocase associated motor 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transcription factor AP-4 (activating enhancer binding protein 4; TFAP4) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 
negative regulation by host of viral transcription IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation by host of viral transcription NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation by host of viral transcription IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic cell cycle phase transition IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
mitochondrion IDA
Inferred from Direct Assay
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional repressor complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
transcription factor AP-4
Names
activating enhancer-binding protein 4
class C basic helix-loop-helix protein 41
transcription factor AP-4 (activating enhancer binding protein 4)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003223.3NP_003214.1  transcription factor AP-4

    See identical proteins and their annotated locations for NP_003214.1

    Status: VALIDATED

    Source sequence(s)
    AC009171, BU159415, DA449763, S73885
    Consensus CDS
    CCDS10510.1
    UniProtKB/Swiss-Prot
    Q01664
    Related
    ENSP00000204517.6, ENST00000204517.11
    Conserved Domains (1) summary
    pfam00010
    Location:49100
    HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    4257186..4273023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522635.3XP_011520937.1  transcription factor AP-4 isoform X2

    See identical proteins and their annotated locations for XP_011520937.1

    Conserved Domains (1) summary
    pfam00010
    Location:140
    HLH; Helix-loop-helix DNA-binding domain
  2. XM_011522633.3XP_011520935.1  transcription factor AP-4 isoform X1

    Conserved Domains (1) summary
    pfam00010
    Location:3687
    HLH; Helix-loop-helix DNA-binding domain
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