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TFAP4 transcription factor AP-4 [ Homo sapiens (human) ]

Gene ID: 7023, updated on 17-Jun-2024

Summary

Official Symbol
TFAP4provided by HGNC
Official Full Name
transcription factor AP-4provided by HGNC
Primary source
HGNC:HGNC:11745
See related
Ensembl:ENSG00000090447 MIM:600743; AllianceGenome:HGNC:11745
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AP-4; bHLHc41
Summary
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]
Expression
Ubiquitous expression in ovary (RPKM 4.0), spleen (RPKM 3.0) and 25 other tissues See more
Orthologs
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Genomic context

See TFAP4 in Genome Data Viewer
Location:
16p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (4257186..4273023, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (4284515..4300348, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4307187..4323024, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene sarcalumenin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4302672-4303294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7148 Neighboring gene long intergenic non-protein coding RNA 1569 Neighboring gene uncharacterized LOC124903634 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4314566-4315209 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4315210-4315854 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4321241-4322217 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10338 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:4323195-4324170 Neighboring gene Sharpr-MPRA regulatory region 12742 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:4336703-4337204 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:4337205-4337704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10339 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:4340142-4340760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4344437-4345096 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4346736-4347609 Neighboring gene Sharpr-MPRA regulatory region 643 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4355312-4355824 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:4362415-4362646 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr16:4364183-4364695 and GRCh37_chr16:4364696-4365208 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4367330-4367980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4367981-4368630 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4372394-4373179 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4374751-4375535 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4378569-4379569 Neighboring gene GLIS2 antisense RNA 1 Neighboring gene GLIS family zinc finger 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4389543-4390289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4390290-4391035 Neighboring gene CORO7-PAM16 readthrough Neighboring gene MPRA-validated peak2471 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4397350-4397850 Neighboring gene presequence translocase associated motor 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transcription factor AP-4 (activating enhancer binding protein 4; TFAP4) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation by host of viral transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation by host of viral transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation by host of viral transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mitotic cell cycle phase transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription repressor complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
transcription factor AP-4
Names
activating enhancer-binding protein 4
class C basic helix-loop-helix protein 41
transcription factor AP-4 (activating enhancer binding protein 4)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003223.3NP_003214.1  transcription factor AP-4

    See identical proteins and their annotated locations for NP_003214.1

    Status: VALIDATED

    Source sequence(s)
    AC009171, BU159415, DA449763, S73885
    Consensus CDS
    CCDS10510.1
    UniProtKB/Swiss-Prot
    O60409, Q01664
    UniProtKB/TrEMBL
    Q6FHM5
    Related
    ENSP00000204517.6, ENST00000204517.11
    Conserved Domains (1) summary
    pfam00010
    Location:49100
    HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    4257186..4273023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522635.4XP_011520937.1  transcription factor AP-4 isoform X3

    See identical proteins and their annotated locations for XP_011520937.1

    UniProtKB/TrEMBL
    Q6FHM5
    Conserved Domains (1) summary
    pfam00010
    Location:140
    HLH; Helix-loop-helix DNA-binding domain
  2. XM_011522633.4XP_011520935.1  transcription factor AP-4 isoform X2

    UniProtKB/TrEMBL
    Q6FHM5
    Conserved Domains (1) summary
    pfam00010
    Location:3687
    HLH; Helix-loop-helix DNA-binding domain
  3. XM_047434553.1XP_047290509.1  transcription factor AP-4 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    4284515..4300348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313810.1XP_054169785.1  transcription factor AP-4 isoform X3

    UniProtKB/TrEMBL
    Q6FHM5
  2. XM_054313809.1XP_054169784.1  transcription factor AP-4 isoform X2

    UniProtKB/TrEMBL
    Q6FHM5
  3. XM_054313808.1XP_054169783.1  transcription factor AP-4 isoform X1