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Conserved domains on  [gi|1039751981|ref|XP_017172655|]
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transcription factor AP-4 isoform X1 [Mus musculus]

Protein Classification

basic helix-loop-helix domain-containing protein( domain architecture ID 14413323)

basic helix-loop-helix (bHLH) domain-containing protein is a DNA-binding protein that may act as a transcription factor; similar to Homo sapiens transcription factor AP-4 that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'

Gene Ontology:  GO:0003677
PubMed:  20219281

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
bHLHzip_TFAP4 cd11419
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ...
26-86 4.18e-36

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.


:

Pssm-ID: 381425  Cd Length: 61  Bit Score: 124.35  E-value: 4.18e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039751981  26 RRIRREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRL 86
Cdd:cd11419     1 RRIRREIANSNERRRMQSINAGFQSLRTLLPHCDGEKLSKAAILQQTAEYIFSLEQEKTRL 61
 
Name Accession Description Interval E-value
bHLHzip_TFAP4 cd11419
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ...
26-86 4.18e-36

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.


Pssm-ID: 381425  Cd Length: 61  Bit Score: 124.35  E-value: 4.18e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039751981  26 RRIRREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRL 86
Cdd:cd11419     1 RRIRREIANSNERRRMQSINAGFQSLRTLLPHCDGEKLSKAAILQQTAEYIFSLEQEKTRL 61
HLH pfam00010
Helix-loop-helix DNA-binding domain;
29-80 3.54e-13

Helix-loop-helix DNA-binding domain;


Pssm-ID: 425419 [Multi-domain]  Cd Length: 53  Bit Score: 62.86  E-value: 3.54e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYIFSLE 80
Cdd:pfam00010   1 RRAAHNERERRRRDRINDAFDELRELLPtLPPDKKLSKAEILRLAIEYIKHLQ 53
HLH smart00353
helix loop helix domain;
34-82 1.81e-12

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 61.08  E-value: 1.81e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039751981   34 NSNERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYIFSLEQE 82
Cdd:smart00353   1 NARERRRRRKINEAFDELRSLLPtLPKNKKLSKAEILRLAIEYIKSLQEE 50
 
Name Accession Description Interval E-value
bHLHzip_TFAP4 cd11419
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ...
26-86 4.18e-36

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.


Pssm-ID: 381425  Cd Length: 61  Bit Score: 124.35  E-value: 4.18e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039751981  26 RRIRREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRL 86
Cdd:cd11419     1 RRIRREIANSNERRRMQSINAGFQSLRTLLPHCDGEKLSKAAILQQTAEYIFSLEQEKTRL 61
HLH pfam00010
Helix-loop-helix DNA-binding domain;
29-80 3.54e-13

Helix-loop-helix DNA-binding domain;


Pssm-ID: 425419 [Multi-domain]  Cd Length: 53  Bit Score: 62.86  E-value: 3.54e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYIFSLE 80
Cdd:pfam00010   1 RRAAHNERERRRRDRINDAFDELRELLPtLPPDKKLSKAEILRLAIEYIKHLQ 53
HLH smart00353
helix loop helix domain;
34-82 1.81e-12

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 61.08  E-value: 1.81e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039751981   34 NSNERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYIFSLEQE 82
Cdd:smart00353   1 NARERRRRRKINEAFDELRSLLPtLPKNKKLSKAEILRLAIEYIKSLQEE 50
bHLH_TS cd11390
tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain ...
30-81 1.14e-10

tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain family includes transcription regulators whose expression are restricted to certain tissues. They are involved in cell-fate determination and process in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis and include proteins from myogenic regulatory factor (MRF) family, twist-related protein (TWIST) family, scleraxis-like family, heart- and neural crest derivatives-expressed protein (HAND) family, helix-loop-helix protein (HEN) family, musculin-like family, germline alpha (FIGLA) family, T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family, ovary, uterus and testis protein (OUT) family, mesoderm posterior protein (Mesp) family, muscle, intestine and stomach expression 1 (MIST-1) family, protein atonal homologs (ATOH) family, neurogenin (NGN) family, neurogenic differentiation factor (NeuroD) family, achaete-scute complex-like (ASCL) family, Fer3-like protein (FERD3L)-like family, and Oligodendrocyte lineage genes (OLIG) family of transcription factors.


Pssm-ID: 381396 [Multi-domain]  Cd Length: 55  Bit Score: 56.04  E-value: 1.14e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039751981  30 REIANSNERRRMQSINAGFQSLKTLIPH-TDGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd11390     1 RNAANARERRRMHDLNDAFEALRKVLPTvPPDKKLSKIETLRLAINYIAALSD 53
bHLH_SF cd00083
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
37-81 1.00e-09

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


Pssm-ID: 381392 [Multi-domain]  Cd Length: 46  Bit Score: 53.29  E-value: 1.00e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1039751981  37 ERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd00083     1 ERRRRDKINDAFEELKRLLPeLPDSKKLSKASILQKAVEYIRELQS 46
bHLH_TS_ATOH8 cd11421
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 8 (ATOH8) and similar ...
27-92 1.06e-09

basic helix-loop-helix (bHLH) domain found in protein atonal homolog 8 (ATOH8) and similar proteins; ATOH8, also termed Class A basic helix-loop-helix protein 21 (bHLHa21), or helix-loop-helix protein hATH-6 (hATH6), is a bHLH shear-stress-responsive transcription factor expressed in activated satellite cells and proliferating myoblasts of human skeletal muscle tissue. It regulates endothelial cell proliferation, migration and tube-like structures formation. ATOH8 binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins.


Pssm-ID: 381427 [Multi-domain]  Cd Length: 68  Bit Score: 53.98  E-value: 1.06e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039751981  27 RIRREIANSNERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYIFSLeqekTRLLQQNTQ 92
Cdd:cd11421     6 RQRRIEANARERTRVHTISAAFEALRKAVPsYSYNQKLSKLAILRIACSYILAL----ARLADLDYS 68
bHLHzip_MLXIP_like cd11405
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), ...
27-97 2.06e-09

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), MLX-interacting protein-like (MLXIPL) and similar proteins; The family includes MLXIP and MLXIPL. MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm. MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381411 [Multi-domain]  Cd Length: 74  Bit Score: 53.05  E-value: 2.06e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039751981  27 RIRREIANSNERRRMQSINAGFQSLKTLIP---HTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFI 97
Cdd:cd11405     1 EQRRLSHISAEQKRRFNIKSGFDTLQSLIPslgQNPNQKVSKAAMLQKAAEYIKSLKRERQQMQEEAEQLRQEI 74
bHLHzip_Mlx_like cd11404
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, ...
29-95 2.89e-09

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription. The family also includes Saccharomyces cerevisiae INO4, which is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast.


Pssm-ID: 381410 [Multi-domain]  Cd Length: 70  Bit Score: 52.69  E-value: 2.89e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKR 95
Cdd:cd11404     2 RRLNHVRSEKKRRELIKKGYDELCALVPGLDPQKRTKADILQKAADWIQELKEENEKLEEQLDELKE 68
bHLH_TS_ATOH1_like cd11430
basic helix-loop-helix (bHLH) domain found in protein atonal homologs ATOH1, ATOH7 and similar ...
29-82 2.29e-08

basic helix-loop-helix (bHLH) domain found in protein atonal homologs ATOH1, ATOH7 and similar proteins; The family includes ATOH1 and ATOH7. ATOH1, also termed Class A basic helix-loop-helix protein 14 (bHLHa14), or helix-loop-helix protein hATH-1 (hATH1), or Math1, or Cath1, is a proneural bHLH transcription factor that is essential for inner ear hair cell differentiation. It dimerizes with E47 and activates E-box (CANNTG) dependent transcription. ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal and mouse atonal homolog 1 (Math1). ATOH7, also termed Class A basic helix-loop-helix protein 13 (bHLHa13), or helix-loop-helix protein hATH-5 (hATH5), or Math5, is a bHLH transcription factor involved in the differentiation of retinal ganglion cells. The family also includes protein Amos (also termed absent MD neurons and olfactory sensilla protein, or reduced olfactory organs protein, or rough eye protein). It is a bHLH transcription factor that promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system.


Pssm-ID: 381436 [Multi-domain]  Cd Length: 56  Bit Score: 49.74  E-value: 2.29e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGE-KLSKAAILQQTAEYIFSLEQE 82
Cdd:cd11430     1 RRLAANARERRRMNGLNRAFDQLRSVVPSIGNDkKLSKYETLQMAQIYIETLSEL 55
bHLHzip_SREBP cd11394
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
28-95 2.56e-08

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box.


Pssm-ID: 381400  Cd Length: 73  Bit Score: 49.96  E-value: 2.56e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039751981  28 IRREIANSNERRRMQSINAGFQSLKTLIPHTDGeKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKR 95
Cdd:cd11394     5 EKRSAHNAIEKRYRSSINDRIIELKDLVVGPDA-KMNKSAVLRKAIDYIRYLQKVNQKLKQENMALKK 71
bHLH_TS_taxi_Dei cd11431
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein taxi and similar ...
29-81 4.05e-08

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein taxi and similar proteins; Protein taxi, also termed protein delilah (Dei), is a bHLH transcription factor that is involved in regulation of cell adhesion and attachment that is expressed in specialized cells that provide anchoring sites to either muscles (tendon cells), or proprioceptors (chordotonal attachment cells) during embryonic development. It probably plays an important role in the differentiation of epidermal cells into the tendon cells that form the attachment sites for all muscles.


Pssm-ID: 381437 [Multi-domain]  Cd Length: 59  Bit Score: 48.96  E-value: 4.05e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIP----HTDGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd11431     1 RRKTANARERDRMREINDAFEALRRAVPeypvAGKDGKLTKITTLRLAMNYIKALTD 57
bHLHzip_scCBP1 cd11398
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae ...
23-94 2.64e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae centromere-binding protein 1 (CBP-1) and similar proteins; CBP-1, also termed centromere promoter factor 1 (CPF1), or centromere-binding factor 1 (CBF1), is a bHLHzip protein that is required for chromosome stability and methionine prototrophy. It binds as a homodimer to the centromere DNA elements I (CDEI, GTCACATG) region of the centromere that is required for optimal centromere function.


Pssm-ID: 381404 [Multi-domain]  Cd Length: 89  Bit Score: 47.72  E-value: 2.64e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039751981  23 DQERRIRREIANSNERRRMQSINAGFQSLKTLIPHTDGEKlSKAAILQQTAEYIFSLEQEKTRLLQQNTQLK 94
Cdd:cd11398     1 EEWHRQRRDNHKEVERRRRENINEGINELAALVPGNAREK-NKGAILARAVEYIQELQETEAKNIEKWTLEK 71
bHLHzip_Mlx cd19687
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar ...
29-95 3.61e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription.


Pssm-ID: 381530 [Multi-domain]  Cd Length: 76  Bit Score: 47.03  E-value: 3.61e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIP---HTD---GEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKR 95
Cdd:cd19687     2 RREAHTQAEQKRRDAIKKGYDDLQDIVPtcqQQDdigSQKLSKATILQRSIDYIQFLHQQKKKQEEELSALRK 74
bHLHzip_USF3 cd18910
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in basic helix-loop-helix ...
25-89 3.77e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in basic helix-loop-helix domain-containing protein USF3 and similar proteins; USF3, also termed upstream transcription factor 3, is a bHLHzip protein that is involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties.


Pssm-ID: 381480  Cd Length: 65  Bit Score: 46.52  E-value: 3.77e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039751981  25 ERRIRREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQ 89
Cdd:cd18910     1 RREKKRESHNEVERRRKDKINAGINKIGELLPDRDAKKQSKNMILEQAYKYIVELKKKNDKLLLN 65
bHLHzip_Max cd11406
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, ...
29-95 3.89e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, also termed Class D basic helix-loop-helix protein 4 (bHLHd4), or Myc-associated factor X, is a bHLHZip transcription regulator that forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a transcriptional repressor. Max homodimer bind DNA but is transcriptionally inactive. Targeted deletion of max results in early embryonic lethality in mice.


Pssm-ID: 381412  Cd Length: 69  Bit Score: 46.58  E-value: 3.89e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKR 95
Cdd:cd11406     1 KRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILKKATEYIQYMRRKNHTHQQDIDDLKR 67
bHLHzip_USF_MITF cd11387
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream ...
34-82 6.93e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381393 [Multi-domain]  Cd Length: 58  Bit Score: 45.71  E-value: 6.93e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039751981  34 NSNERRRMQSINAGFQSLKTLIP----HTDGEKLSKAAILQQTAEYIFSLEQE 82
Cdd:cd11387     3 NAVERRRRDNINEKIQELGSLVPpsrlETKDLKPNKGSILSKAVEYIRELQNQ 55
bHLHzip_SREBP1 cd18921
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
29-99 9.16e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 1 (SREBP1) and similar proteins; SREBP1, also termed Class D basic helix-loop-helix protein 1 (bHLHd1), or sterol regulatory element-binding transcription factor 1 (SREBF1), is a member of a family of bHLHzip transcription factors that recognize sterol regulatory element 1 (SRE-1). It acts as a transcriptional activator required for lipid homeostasis. It may control transcription of the low-density lipoprotein receptor gene as well as the fatty acid. SREBP1 has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').


Pssm-ID: 381491  Cd Length: 75  Bit Score: 45.65  E-value: 9.16e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGeKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQE 99
Cdd:cd18921     6 KRTAHNAIEKRYRSSINDKIIELKDLVVGTEA-KLNKSAVLRKAIDYIRFLQQSNQKLKQENMALKMAVQK 75
bHLH_TS_ASCL cd11418
basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The ...
34-82 1.22e-06

basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The achaete-scute complex-like (ASCL, also known as achaete-scute complex homolog or ASH) family of bHLH transcription factors, ASCL1-5, have been implicated in cell fate specification and differentiation. They are critical for proper development of the nervous system. The deregulation of ASCL plays a key role in psychiatric and neurological disorders. ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete-scute homolog 1 (Mash1), is a neural-specific bHLH transcription factor that is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete-scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves. ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is a bHLH transcription factor specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis. The family also includes Drosophila melanogaster achaete-scute complex (AS-C) proteins, which consists of lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation.


Pssm-ID: 381424 [Multi-domain]  Cd Length: 56  Bit Score: 44.91  E-value: 1.22e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039751981  34 NSNERRRMQSINAGFQSLKTLIPHT-DGEKLSKAAILQQTAEYIFSLEQE 82
Cdd:cd11418     6 NERERRRVQAVNDAFDRLRQHVPYLkRRKKLSKVKTLRRAIEYIRHLQKL 55
bHLH_TS_ATOH7 cd19714
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 7 (ATOH7) and similar ...
29-89 1.46e-06

basic helix-loop-helix (bHLH) domain found in protein atonal homolog 7 (ATOH7) and similar proteins; ATOH7, also termed Class A basic helix-loop-helix protein 13 (bHLHa13), or helix-loop-helix protein hATH-5 (hATH5), or Math5, is a bHLH transcription factor involved in the differentiation of retinal ganglion cells.


Pssm-ID: 381557 [Multi-domain]  Cd Length: 69  Bit Score: 44.94  E-value: 1.46e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPH-TDGEKLSKAAILQQTAEYIFSLeqekTRLLQQ 89
Cdd:cd19714     8 RRLAANARERRRMQGLNTAFDRLRKVVPQwGQDKKLSKYETLQMALSYIMAL----TRILAE 65
bHLH_TS_TWIST1 cd11412
basic helix-loop-helix (bHLH) domain found in twist-related protein 1 (TWIST1) and similar ...
20-81 2.89e-06

basic helix-loop-helix (bHLH) domain found in twist-related protein 1 (TWIST1) and similar proteins; TWIST1, also termed Class A basic helix-loop-helix protein 38 (bHLHa38), or H-twist, is a bHLH transcriptional regulator that inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. It also represses expression of proinflammatory cytokines such as TNFA and IL1B. In addition, TWIST1 is involved in cancer development and progression.


Pssm-ID: 381418 [Multi-domain]  Cd Length: 77  Bit Score: 44.39  E-value: 2.89e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039751981  20 TQRDQERRIRREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd11412     3 PQSFEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQ 64
bHLH_TS_dimmed_like cd19712
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein dimmed and ...
29-79 3.77e-06

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein dimmed and similar proteins; Dimmed, also termed DIMM, is a bHLH transcription factor that regulates neurosecretory (NS) cell function and neuroendocrine cell fate in Drosophila.


Pssm-ID: 381555 [Multi-domain]  Cd Length: 60  Bit Score: 43.63  E-value: 3.77e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGE-KLSKAAILQQTAEYIFSL 79
Cdd:cd19712     1 RRLESNERERMRMHSLNDAFQGLREVIPHVNAErKLSKIETLTLAKNYIKAL 52
bHLH_TS_MIST1 cd19711
basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 ...
29-79 4.38e-06

basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 (MIST-1) and similar proteins; MIST-1, also termed Class A basic helix-loop-helix protein 15 (bHLHa15), or Class B basic helix-loop-helix protein 8 (bHLHb8), is a bHLH transcription factor expressed in pancreatic acinar cells and other serous exocrine cells. It is essential for cytoskeletal organization and secretory activity. It also functions as a potent endoplasmic reticulum (ER) stress-inducible transcriptional regulator. MIST-1 is capable of binding to E-box (CANNTG) motifs as a homodimer or a heterodimer with E-proteins (E12 and E47) to regulate transcription.


Pssm-ID: 381554  Cd Length: 62  Bit Score: 43.55  E-value: 4.38e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGE-KLSKAAILQQTAEYIFSL 79
Cdd:cd19711     1 RRLESNERERQRMHKLNNAFQALREVIPHVRAEkKLSKIETLTLAKNYIKSL 52
bHLH_TS_NGN cd11428
basic helix-loop-helix (bHLH) domain found in neurogenin (NGN) family; The NGN family includes ...
29-81 4.78e-06

basic helix-loop-helix (bHLH) domain found in neurogenin (NGN) family; The NGN family includes three neural-specific bHLH transcription factors, NGN1-3, which may function at neuroblast selection genes during the development of several neuronal lineages. NGN-1, also termed Class A basic helix-loop-helix protein 6 (bHLHa6), or neurogenic basic-helix-loop-helix protein, or neurogenic differentiation factor 3 (NeuroD3), is a neural-specific bHLH transcription factor involved in the initiation of neuronal differentiation. NGN-2, also termed Class A basic helix-loop-helix protein 8 (bHLHa8), or protein atonal homolog 4 (ATOH4), is a neural-specific bHLH transcription factor required for sensory neurogenesis. NGN-3, also termed Class A basic helix-loop-helix protein 7 (bHLHa7), or protein atonal homolog 5 (ATOH5), is a neural-specific bHLH transcription factor expressed in the developing central nervous system and the embryonic pancreas. It is involved in neurogenesis and plays an important role in spermatogenesis.


Pssm-ID: 381434 [Multi-domain]  Cd Length: 57  Bit Score: 43.20  E-value: 4.78e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd11428     1 RRLKANDRERNRMHNLNDALDALREVLPsFPDETKLTKIETLRFAHNYIWALSE 54
bHLH_TS_HAND cd11466
basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed ...
29-76 5.12e-06

basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein (HAND) family; The HAND family includes two bHLH transcription factors, HAND1 and HAND2. HAND1, also termed Class A basic helix-loop-helix protein 27 (bHLHa27), or extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1 (eHAND), plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. HAND2, also termed Class A basic helix-loop-helix protein 26 (bHLHa26), or deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND), is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries.


Pssm-ID: 381472 [Multi-domain]  Cd Length: 56  Bit Score: 43.16  E-value: 5.12e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGE-KLSKAAILQQTAEYI 76
Cdd:cd11466     1 RRGSANKKERRRTQSINSAFADLRECIPNVPADtKLSKIKTLRLATSYI 49
bHLH_TS_amos_like cd19715
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein Amos and similar ...
27-79 5.54e-06

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein Amos and similar proteins; Amos, also termed absent MD neurons and olfactory sensilla protein, or reduced olfactory organs protein, or rough eye protein, is a bHLH transcription factor that promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system.


Pssm-ID: 381558 [Multi-domain]  Cd Length: 64  Bit Score: 43.28  E-value: 5.54e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039751981  27 RIRREIANSNERRRMQSINAGFQSLKTLIPH-TDGEKLSKAAILQQTAEYIFSL 79
Cdd:cd19715     6 KKRRLAANARERRRMNSLNVAFDKLRDVVPSlGDDRKLSKYETLQMAQSYITAL 59
bHLH_TS_FERD3L_like cd19686
basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L), pancreas ...
30-76 7.42e-06

basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L), pancreas transcription factor 1 subunit alpha (PTF1A) and similar proteins; The family corresponds to a group of bHLH transcription factors, including FERD3L and PTF1A. FERD3L, also termed basic helix-loop-helix protein N-twist, or Class A basic helix-loop-helix protein 31 (bHLHa31), or nephew of atonal 3 (NATO3), or Neuronal twist (NTWIST), is expressed in the developing central nervous system (CNS). It regulates floor plate (FP) cells development. FP is a critical organizing center located at the ventral-most midline of the neural tube. FERD3L binds to the E-box and functions as inhibitor of transcription. PTF1A, also termed Class A basic helix-loop-helix protein 29 (bHLHa29), or pancreas-specific transcription factor 1a, or bHLH transcription factor p48, or p48 DNA-binding subunit of transcription factor PTF1 (PTF1-p48), is implicated in the cell fate determination in various organs. It binds to the E-box consensus sequence 5'-CANNTG-3' and plays a role in early and late pancreas development and differentiation.


Pssm-ID: 381529 [Multi-domain]  Cd Length: 56  Bit Score: 42.80  E-value: 7.42e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1039751981  30 REIANSNERRRMQSINAGFQSLKTLIPHTDGEK-LSKAAILQQTAEYI 76
Cdd:cd19686     2 RQAANIRERKRMRSINDAFDGLRRHIPTFPYEKrLSKVDTLRLAIQYI 49
bHLH_TS_FIGLA cd11422
basic helix-loop-helix (bHLH) domain found in factor in the germline alpha (FIGLA) and similar ...
30-81 8.51e-06

basic helix-loop-helix (bHLH) domain found in factor in the germline alpha (FIGLA) and similar proteins; FIGLA, also termed FIGalpha, or Class C basic helix-loop-helix protein 8 (bHLHc8), or folliculogenesis-specific basic helix-loop-helix protein, or transcription factor FIGa, is a germ-cell-specific bHLH transcription factor expressed abundantly in female and less so in male germ cells. It is essential for primordial follicle formation and expression of many genes required for folliculogenesis, fertilization and early embryonic survival. FIGLA knockout mice cannot form primordial follicles and lose oocytes rapidly after birth, whereas male gonads are unaffected.


Pssm-ID: 381428  Cd Length: 56  Bit Score: 42.34  E-value: 8.51e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039751981  30 REIANSNERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd11422     1 RRVANARERERVRNLNSGFSKLRRIVPlIPRDRKPSKVDTLKGATEYIRLLQR 53
bHLH_TS_PTF1A cd11417
basic helix-loop-helix (bHLH) domain found in pancreas transcription factor 1 subunit alpha ...
29-76 8.62e-06

basic helix-loop-helix (bHLH) domain found in pancreas transcription factor 1 subunit alpha (PTF1A) and similar proteins; PTF1A, also termed Class A basic helix-loop-helix protein 29 (bHLHa29), or pancreas-specific transcription factor 1a, or bHLH transcription factor p48, or p48 DNA-binding subunit of transcription factor PTF1 (PTF1-p48), is a bHLH transcription factor implicated in the cell fate determination in various organs. It binds to the E-box consensus sequence 5'-CANNTG-3' and plays a role in early and late pancreas development and differentiation.


Pssm-ID: 381423 [Multi-domain]  Cd Length: 56  Bit Score: 42.52  E-value: 8.62e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGEK-LSKAAILQQTAEYI 76
Cdd:cd11417     1 QRQAANLRERRRMQSINDAFEGLRSHIPTLPYEKrLSKVDTLRLAIGYI 49
bHLH_TS_ATOH1 cd19713
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 1 (ATOH1) and similar ...
29-81 9.19e-06

basic helix-loop-helix (bHLH) domain found in protein atonal homolog 1 (ATOH1) and similar proteins; ATOH1, also termed Class A basic helix-loop-helix protein 14 (bHLHa14), or helix-loop-helix protein hATH-1 (hATH1), or Math1, or Cath1, is a proneural bHLH transcription factor that is essential for inner ear hair cell differentiation. It dimerizes with E47 and activates E-box (CANNTG) dependent transcription. ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal and mouse atonal homolog 1 (Math1).


Pssm-ID: 381556  Cd Length: 64  Bit Score: 42.63  E-value: 9.19e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGE-KLSKAAILQQTAEYIFSLEQ 81
Cdd:cd19713     6 RRLAANARERRRMHGLNHAFDQLRNVIPSFNNDkKLSKYETLQMAQIYINALSE 59
bHLH_AtBIM_like cd11453
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BES1-interacting Myc-like ...
37-93 9.34e-06

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BES1-interacting Myc-like proteins (BIMs) and similar proteins; The family includes Arabidopsis thaliana BIM1 and its homologs (BIM2 and BIM3), which are bHLH transcription factors that interact with BES1 to regulate transcription of Brassinosteroid (BR)-induced gene. BR regulates many growth and developmental processes such as cell elongation, vascular development, senescence stress responses, and photomorphogenesis. BIM1 heterodimerize with BES1 and bind to E-box sequences present in many BR-induced promoters to regulated BR-induced genes.


Pssm-ID: 381459  Cd Length: 77  Bit Score: 42.85  E-value: 9.34e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039751981  37 ERRRMQSINAGFQSLKTLIPHTDgEKLSKAAILQQTAEYIFSLeQEKTRLLQQNTQL 93
Cdd:cd11453    11 EQRRRSKINERLQALRDLIPHSD-QKRDKASFLLEVIEYIQAL-QEKVAKLEEQVQG 65
bHLH_TS_TAL_LYL cd11413
basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein/ ...
29-80 9.48e-06

basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family; The TAL/LYL family includes a group of bHLH transcription factors (TAL1, TAL2 and LYL1) implicated in T cell acute leukaemia. They act as mediators of T cell leukaemogenesis. TAL-1, also termed Class A basic helix-loop-helix protein 17 (bHLHa17), or stem cell protein (SCL), or T-cell leukemia/lymphoma protein 5, is a hematopoietic-specific bHLH transcription factor that functions in embryonic and adult hematopoiesis in vertebrates. It is also required for embryonic vascular remodeling. It acts as a regulator of erythroid differentiation and binds to regulatory regions of a large cohort of erythroid genes as part of a complex with GATA-1, LMO2 and Ldb1. TAL-2, also termed Class A basic helix-loop-helix protein 19 (bHLHa19), is a bHLH transcription factor essential for the normal brain development. Lyl-1, also termed Class A basic helix-loop-helix protein 18 (bHLHa18), or lymphoblastic leukemia-derived sequence 1, is a proto-oncogenic bHLH transcription factor that plays an important role in hematopoietic stem cell function and is required for the late stages of postnatal angiogenesis to limit the formation of new blood vessels, notably by regulating the activity of the small GTPase Rap1. LYL-1 deficiency induces a stress erythropoiesis.


Pssm-ID: 381419 [Multi-domain]  Cd Length: 60  Bit Score: 42.44  E-value: 9.48e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYIFSLE 80
Cdd:cd11413     1 RRIFTNTRERWRQQNVNGAFAELRKLIPtHPPDKKLSKNEILRLAMKYIKFLE 53
bHLH_TS_TWIST2 cd19700
basic helix-loop-helix (bHLH) domain found in twist-related protein 2 (TWIST2) and similar ...
17-81 9.92e-06

basic helix-loop-helix (bHLH) domain found in twist-related protein 2 (TWIST2) and similar proteins; TWIST2, also termed Class A basic helix-loop-helix protein 39 (bHLHa39), or Dermis-expressed protein 1, or Dermo-1, is a bHLH transcription factor that regulates the development of mesenchymal tissues and plays a critical role in embryogenesis. It binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C.


Pssm-ID: 381543 [Multi-domain]  Cd Length: 82  Bit Score: 43.24  E-value: 9.92e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039751981  17 TPETQRDQERRIRREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd19700     5 SPSSQSYEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQ 69
bHLH_TS_NeuroD6_ATOH2 cd19722
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 6 (NeuroD6) ...
20-81 1.13e-05

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 6 (NeuroD6) and similar proteins; NeuroD6, also termed Class A basic helix-loop-helix protein 2 (bHLHa2), or protein atonal homolog 2 (ATH-2), or Atoh2, or Math2, or Nex1, is a neurogenic bHLH transcription factor involved in neuronal development, differentiation, and survival in Alzheimer's disease (AD) brains of both cohorts. It plays an integrative role in coordinating increase in mitochondrial mass with cytoskeletal remodeling, suggesting that it may act as a co-regulator of neuronal differentiation and energy metabolism.


Pssm-ID: 381565 [Multi-domain]  Cd Length: 70  Bit Score: 42.71  E-value: 1.13e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039751981  20 TQRDQER-RIRREIANSNERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd19722     4 TKARMERvKVRRQEANARERNRMHGLNDALDSLRKVVPcYSKTQKLSKIETLRLAKNYIWALSE 67
bHLH_TS_TWIST cd11464
basic helix-loop-helix (bHLH) domain found in twist-related protein (TWIST) family; The TWIST ...
29-81 1.19e-05

basic helix-loop-helix (bHLH) domain found in twist-related protein (TWIST) family; The TWIST family includes TWIST1 and TWIST2, which are highly homologous bHLH transcription factors that promote epithelial-mesenchymal transition (EMT) during development and tumor metastasis. They are involved in the negative regulation of cellular determination and in the differentiation of several lineages, including myogenesis, osteogenesis, and neurogenesis. TWIST factors express in broad partially-overlapping patterns during embryo development and dimerize with a broad sets of dimer partners that form numerous unique transcriptional complexes to regulate embryonic development.


Pssm-ID: 381470 [Multi-domain]  Cd Length: 59  Bit Score: 42.09  E-value: 1.19e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd11464     1 QRVLANVRERQRTQSLNEAFTSLRKIIPTLPSDKLSKIQTLKLAARYIDFLYQ 53
bHLHzip_MLXIP cd19688
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and ...
29-97 1.41e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and similar proteins; MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm.


Pssm-ID: 381531  Cd Length: 72  Bit Score: 42.24  E-value: 1.41e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGEK-LSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFI 97
Cdd:cd19688     3 RRMKHISAEQKRRFNIKICFDTLNSLVSTLKNSKpISNAITLQKTVEYIAKLQQERTQMQEETKRLREEI 72
bHLHzip_MLXIPL cd19689
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) ...
29-94 1.46e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins; MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381532  Cd Length: 76  Bit Score: 42.65  E-value: 1.46e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGE---KLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLK 94
Cdd:cd19689     5 RRITHISAEQKRRFNIKLGFDTLHSLVTTLSSQpsiKISKATTLQKTAEYISKLQQERAQLQEEAQRLR 73
bHLH_TS_dHLH3B_like cd19708
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster helix loop helix protein ...
29-80 1.82e-05

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster helix loop helix protein 3B (dHLH3B) and similar proteins; Drosophila HLH3B is an uncharacterized bHLH transcription factor that belongs to the T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family.


Pssm-ID: 381551  Cd Length: 60  Bit Score: 41.80  E-value: 1.82e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYIFSLE 80
Cdd:cd19708     1 RRMFTNSRERWRQQNVNGAFAELRKLVPtHPPDKKLSKNEILRLAIKYIRLLS 53
bHLH_TS_HAND2 cd11471
basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed ...
29-76 3.15e-05

basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 2 (HAND2) and similar proteins; HAND2, also termed Class A basic helix-loop-helix protein 26 (bHLHa26), or deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND), is a bHLH transcription factor that is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries.


Pssm-ID: 381477 [Multi-domain]  Cd Length: 62  Bit Score: 41.20  E-value: 3.15e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGE-KLSKAAILQQTAEYI 76
Cdd:cd11471     1 RRGTANRKERRRTQSINSAFAELRECIPNVPADtKLSKIKTLRLATSYI 49
bHLH_TS_scleraxis_like cd11465
basic helix-loop-helix (bHLH) domain found in scleraxis, transcription factor 15 (TCF-15) and ...
30-80 3.58e-05

basic helix-loop-helix (bHLH) domain found in scleraxis, transcription factor 15 (TCF-15) and similar proteins; The family includes scleraxis and transcription factor 15 (TCF-15). Scleraxis, also termed SCX, or Class A basic helix-loop-helix protein 41 (bHLHa41), or Class A basic helix-loop-helix protein 48 (bHLHa48), is a bHLH transcription factor that is expressed in sclerotome limb bud cranial and body wall mesenchyme, pericardium and heart valves, ligaments and tendons. It is required for tendon formation ligaments, connective tissue, the diaphragm, and testis development. Scleraxis plays a central role in promoting fibroblast proliferation and matrix synthesis during the embryonic development of tendons. TCF-15, also termed Class A basic helix-loop-helix protein 40 (bHLHa40), or paraxis, or protein bHLH-EC2, is a bHLH transcription factor expressed in caudal lateral and paraxial mesoderm dermomyotome and sclerotome fore limb buds during embryo development. It may function as an early transcriptional regulator involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.


Pssm-ID: 381471 [Multi-domain]  Cd Length: 55  Bit Score: 40.86  E-value: 3.58e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039751981  30 REIANSNERRRMQSINAGFQSLKTLIPhTD--GEKLSKAAILQQTAEYIFSLE 80
Cdd:cd11465     1 RQAANARERDRTHSVNSAFTALRTLIP-TEpaDRKLSKIETLRLASSYISHLA 52
bHLHzip_Myc cd11400
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a ...
29-101 3.80e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).


Pssm-ID: 381406 [Multi-domain]  Cd Length: 80  Bit Score: 41.38  E-value: 3.80e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHT-DGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQELS 101
Cdd:cd11400     1 KRRLHNVLERQRRNDLKNSFEKLRDLVPELaDNEKASKVVILKKATEYIKQLQQEEKKLEKEKDKLKARNEQLR 74
bHLH_TS_LYL1 cd19705
basic helix-loop-helix (bHLH) domain found in protein lyl-1 and similar proteins; Lyl-1, also ...
29-76 4.05e-05

basic helix-loop-helix (bHLH) domain found in protein lyl-1 and similar proteins; Lyl-1, also termed Class A basic helix-loop-helix protein 18 (bHLHa18), or lymphoblastic leukemia-derived sequence 1, is a proto-oncogenic bHLH transcription factor involved in T-cell acute lymphoblastic leukemia. It plays an important role in hematopoietic stem cell function and is required for the late stages of postnatal angiogenesis to limit the formation of new blood vessels, notably by regulating the activity of the small GTPase Rap1. LYL-1 deficiency induces a stress erythropoiesis.


Pssm-ID: 381548 [Multi-domain]  Cd Length: 65  Bit Score: 40.77  E-value: 4.05e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYI 76
Cdd:cd19705     6 RRVFTNSRERWRQQNVNGAFAELRKLIPtHPPDKKLSKNEILRLAMKYI 54
bHLH_TS_MIST1_like cd11426
basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 ...
29-79 4.53e-05

basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 (MIST-1) family; MIST-1, also termed Class A basic helix-loop-helix protein 15 (bHLHa15), or Class B basic helix-loop-helix protein 8 (bHLHb8), is a bHLH transcription factor expressed in pancreatic acinar cells and other serous exocrine cells. It is essential for cytoskeletal organization and secretory activity. It also functions as a potent endoplasmic reticulum (ER) stress-inducible transcriptional regulator. MIST-1 is capable of binding to E-box (CANNTG) motifs as a homodimer or a heterodimer with E-proteins (E12 and E47) to regulate transcription. The family also includes Drosophila melanogaster protein dimmed and similar proteins. Dimmed, also termed DIMM, is a bHLH transcription factor that regulates neurosecretory (NS) cell function and neuroendocrine cell fate in Drosophila.


Pssm-ID: 381432  Cd Length: 56  Bit Score: 40.65  E-value: 4.53e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGE-KLSKAAILQQTAEYIFSL 79
Cdd:cd11426     1 RRLESNERERLRMHQLNDAFQALREVIPHVRSErKLSKIETLTLAKNYIKSL 52
bHLH_TS_NGN3_ATOH5 cd19718
basic helix-loop-helix (bHLH) domain found in neurogenin-3 (NGN-3) and similar proteins; NGN-3, ...
24-81 6.05e-05

basic helix-loop-helix (bHLH) domain found in neurogenin-3 (NGN-3) and similar proteins; NGN-3, also termed Class A basic helix-loop-helix protein 7 (bHLHa7), or protein atonal homolog 5 (ATOH5), is a neural-specific bHLH transcription factor expressed in the developing central nervous system and the embryonic pancreas. It is involved in neurogenesis and plays an important role in spermatogenesis.


Pssm-ID: 381561 [Multi-domain]  Cd Length: 68  Bit Score: 40.40  E-value: 6.05e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039751981  24 QERRIRREIANSNERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd19718     3 KQKRNRRMKANDRERNRMHNLNSALDALRSVLPtFPDDAKLTKIETLRFAHNYIWALTE 61
bHLH_TS_TAL1 cd19706
basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 ...
28-76 6.71e-05

basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins; TAL-1, also termed Class A basic helix-loop-helix protein 17 (bHLHa17), or stem cell protein (SCL), or T-cell leukemia/lymphoma protein 5, is a hematopoietic-specific bHLH transcription factor that functions in embryonic and adult hematopoiesis in vertebrates. It is also required for embryonic vascular remodeling. It acts as a regulator of erythroid differentiation and binds to regulatory regions of a large cohort of erythroid genes as part of a complex with GATA-1, LMO2 and Ldb1. TAL-1 has been implicated in T-cell acute lymphoblastic leukemia. In common with other tissue-specific bHLH proteins, Tal heterodimerizes with ubiquitously-expressed members of the E2A family and form a DNA-binding complex with an E-box (CANNTG) to regulate transcription at its recognition site.


Pssm-ID: 381549 [Multi-domain]  Cd Length: 65  Bit Score: 40.41  E-value: 6.71e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039751981  28 IRREIANSNERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYI 76
Cdd:cd19706     3 VRRIFTNSRERWRQQNVNGAFAELRKLIPtHPPDKKLSKNEILRLAMKYI 52
bHLH_TS_TCF15_paraxis cd11470
basic helix-loop-helix (bHLH) domain found in transcription factor 15 (TCF-15) and similar ...
29-79 8.60e-05

basic helix-loop-helix (bHLH) domain found in transcription factor 15 (TCF-15) and similar proteins; TCF-15, also termed Class A basic helix-loop-helix protein 40 (bHLHa40), or paraxis, or protein bHLH-EC2, is a bHLH transcription factor expressed in caudal lateral and paraxial mesoderm dermomyotome and sclerotome fore limb buds during embryo development. It may function as an early transcriptional regulator involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.


Pssm-ID: 381476 [Multi-domain]  Cd Length: 66  Bit Score: 40.07  E-value: 8.60e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTD-GEKLSKAAILQQTAEYIFSL 79
Cdd:cd11470     8 QRQAANARERDRTQSVNTAFTALRTLIPTEPvDRKLSKIETLRLASSYIAHL 59
bHLH_TS_TAL2 cd19707
basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 2 ...
29-76 9.08e-05

basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 2 (TAL-2) and similar proteins; TAL-2, also termed Class A basic helix-loop-helix protein 19 (bHLHa19), is a bHLH transcription factor essential for the normal brain development. It has been implicated in T-cell acute lymphoblastic leukemia.


Pssm-ID: 381550 [Multi-domain]  Cd Length: 61  Bit Score: 39.97  E-value: 9.08e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYI 76
Cdd:cd19707     2 RKIFTNTRERWRQQNVNSAFAELRKLIPtHPPDKKLSKNEILRLAMKYI 50
bHLH_TS_NeuroD2 cd19720
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 2 (NeuroD2) ...
22-81 1.12e-04

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 2 (NeuroD2) and similar proteins; NeuroD2, also termed Class A basic helix-loop-helix protein 1 (bHLHa1), or NeuroD-related factor (NDRF), is a neuronal calcium-dependent bHLH transcription factor that induces neuronal differentiation and promotes neuronal survival. It plays a central role in thalamocortical synaptic maturation. NeuroD2 mediates calcium-dependent transcription activation by binding to E box-containing promoter.


Pssm-ID: 381563 [Multi-domain]  Cd Length: 93  Bit Score: 40.44  E-value: 1.12e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039751981  22 RDQERRIRREIANSNERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd19720    28 RLERSKLRRQKANARERNRMHDLNSALDNLRKVVPcYSKTQKLSKIETLRLAKNYIWALSE 88
bHLHzip_SREBP_like cd11395
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
37-97 1.13e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family and similar proteins; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box. The family also includes Saccharomyces cerevisiae transcription factor HMS1 (also termed high-copy MEP suppressor protein 1) and serine-rich protein TYE7. HMS1 is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation. TYE7, also termed basic-helix-loop-helix protein SGC1, is a putative bHLHzip transcription activator required for Ty1-mediated glycolytic gene expression. TYE7 N-terminal is extremely rich in serine residues. It binds DNA on E-box motifs, 5'-CANNTG-3'. TYE7 is not essential for growth.


Pssm-ID: 381401 [Multi-domain]  Cd Length: 87  Bit Score: 40.39  E-value: 1.13e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039751981  37 ERRRMQSINAGFQSLKTLIP----------------HTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFI 97
Cdd:cd11395    11 EKRYRSNLNTKIERLRDAIPslrspegksddgglggLAPTTKLSKATILTKAIEYIRHLEQENERLEEENEELRQQV 87
bHLH_TS_NGN1_NeuroD3 cd19716
basic helix-loop-helix (bHLH) domain found in neurogenin-1 (NGN-1) and similar proteins; NGN-1, ...
26-89 1.20e-04

basic helix-loop-helix (bHLH) domain found in neurogenin-1 (NGN-1) and similar proteins; NGN-1, also termed Class A basic helix-loop-helix protein 6 (bHLHa6), or neurogenic basic-helix-loop-helix protein, or neurogenic differentiation factor 3 (NeuroD3), is a neural-specific bHLH transcription factor involved in the initiation of neuronal differentiation. It activates transcription by binding to the E box (5'-CANNTG-3').


Pssm-ID: 381559 [Multi-domain]  Cd Length: 77  Bit Score: 40.02  E-value: 1.20e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039751981  26 RRIRREIANSNERRRMQSINAGFQSLKTLIPH-TDGEKLSKAAILQQTAEYIFSLeQEKTRLLQQ 89
Cdd:cd19716    14 KKSRRVKANDRERNRMHNLNAALDELRSVLPSfPDDTKLTKIETLRFAHNYIWAL-SETLRLADQ 77
bHLH_TS_NeuroD4_ATOH3 cd19721
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 4 (NeuroD4) ...
20-81 1.21e-04

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 4 (NeuroD4) and similar proteins; NeuroD4, also termed Class A basic helix-loop-helix protein 4 (bHLHa4), or protein atonal homolog 3 (ATH-3), or Atoh3, or Math-3, is a bHLH transcriptional activator that mediates neuronal differentiation.


Pssm-ID: 381564 [Multi-domain]  Cd Length: 87  Bit Score: 40.06  E-value: 1.21e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039751981  20 TQRDQER-RIRREIANSNERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd19721    20 TKARLERfRARRVKANARERSRMHGLNDALDNLRRVMPcYSKTQKLSKIETLRLARNYIWALSE 83
bHLH_TS_OLIG cd11429
basic helix-loop-helix (bHLH) domain found in Oligodendrocyte lineage genes (OLIG) family of ...
29-81 1.36e-04

basic helix-loop-helix (bHLH) domain found in Oligodendrocyte lineage genes (OLIG) family of transcription factors; The OLIG family includes three bHLH transcription factors, Oligo1-3, which are expressed in both the developing and mature central nervous system. Oligo1 and Oligo2 are expressed in a nervous tissue-specific manner, but Oligo3 is found mainly in non-neural tissues. Oligo (also known as Olig) have key roles in the specification of motor neurons, dorsal interneurons, and oligodendrocytes. Oligo1, also termed Class B basic helix-loop-helix protein 6 (bHLHb6), or Class E basic helix-loop-helix protein 21 (bHLHe21), promotes formation and maturation of oligodendrocytes, especially within the brain. Oligo2, also termed Class B basic helix-loop-helix protein 1 (bHLHb1), or Class E basic helix-loop-helix protein 19 (bHLHe19), or protein kinase C-binding protein 2, or protein kinase C-binding protein RACK17, is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. It cooperates with OLIG1 to establish the MN progenitors (pMN) domain of the embryonic neural tube. Oligo3, also termed Class B basic helix-loop-helix protein 7 (bHLHb7), or Class E basic helix-loop-helix protein 20 (bHLHe20), is expressed in the ventricular zone of the dorsal alar plate of the hindbrain and involved in regulating the development of dorsal and ventral spinal cord. It may determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons. This family also includes two OLIG-related bHLH transcription factors, bHLHe22 and bHLHe23. bHLHe22, also termed Class B basic helix-loop-helix protein 5 (bHLHb5), or trinucleotide repeat-containing gene 20 protein, is a neural-specific transcriptional repressor that is expressed in both excitatory (unipolar brush cells) and inhibitory neurons (cartwheel cells) of the dorsal cochlear nucleus (DCN) during development. It is important for the proper development and/or survival of a number of neural cell types. bHLHe23, also termed Class B basic helix-loop-helix protein 4 (bHLHb4), is expressed in rod bipolar cells and is required for rod bipolar cell maturation. bHLHe23 have roles in spinal interneuron differentiation by mechanisms linked to the Notch signaling pathway. It modulates the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types.


Pssm-ID: 381435  Cd Length: 61  Bit Score: 39.33  E-value: 1.36e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039751981  29 RREIaNSNERRRMQSINAGFQSLKTLIPHTDG---EKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd11429     1 RLKI-NSRERKRMHDLNSALDGLRSVMPYAQGpsvRKLSKIATLLLARNYILMLTQ 55
bHLH_TS_dMYOD_like cd19699
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster myogenic-determination ...
29-81 1.41e-04

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster myogenic-determination protein (dMYOD) and similar proteins; dMYOD, also termed protein nautilus, or Myd, may play an important role in the early development of muscle in Drosophila.


Pssm-ID: 381542  Cd Length: 56  Bit Score: 39.06  E-value: 1.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd19699     2 RRKAATMRERRRLRKVNEAFEVLKRRTCPNPNQRLPKVEILRNAIEYIESLED 54
bHLH_TS_NeuroD cd11427
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor (NeuroD) ...
30-81 1.49e-04

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor (NeuroD) family; The NeuroD family includes NeuroD1, NeuroD2, NeuroD4 and NeuroD6. NeuroD1, also termed Class A basic helix-loop-helix protein 3 (bHLHa3), is a neuronal bHLH transcription factor involved in the development and maintenance of the endocrine pancreas and neuronal elements. It acts as an essential regulator of glutamatergic neuronal differentiation. Loss of NeuroD1 causes ataxia, cerebellar hypoplasia, sensorineural deafness, and severe retinal dystrophy in mice. NeuroD2, also termed Class A basic helix-loop-helix protein 1 (bHLHa1), or NeuroD-related factor (NDRF), is a neuronal calcium-dependent bHLH transcription factor that induces neuronal differentiation and promotes neuronal survival. It plays a central role in thalamocortical synaptic maturation. NeuroD2 mediates calcium-dependent transcription activation by binding to E box-containing promoter. NeuroD4, also termed Class A basic helix-loop-helix protein 4 (bHLHa4), or protein atonal homolog 3 (ATH-3), or Atoh3, or Math-3, is a bHLH transcriptional activator that mediates neuronal differentiation. NeuroD6, also termed Class A basic helix-loop-helix protein 2 (bHLHa2), or protein atonal homolog 2 (ATH-2), or Atoh2, or Math2, or Nex1, is a neurogenic bHLH transcription factor involved in neuronal development, differentiation, and survival in Alzheimer's disease (AD) brains of both cohorts. It plays an integrative role in coordinating increase in mitochondrial mass with cytoskeletal remodeling, suggesting that it may act as a co-regulator of neuronal differentiation and energy metabolism.


Pssm-ID: 381433 [Multi-domain]  Cd Length: 55  Bit Score: 38.92  E-value: 1.49e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039751981  30 REIANSNERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd11427     1 RVKANARERNRMHGLNDALDNLRKVVPcYSKTQKLSKIETLRLARNYIWALSE 53
bHLH_TS_ASCL1_like cd19723
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex ...
34-81 1.78e-04

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex (AS-C) proteins, achaete-scute-like proteins, ASCL1-2, and similar proteins; This subfamily includes Drosophila melanogaster AS-C proteins and two ASCL family of transcription factors, ASCL-1 and ASCL-2. Drosophila melanogaster AS-C proteins includes lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation. ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete scute homolog 1 (Mash1), is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete scute homolog 2 (Mash2), is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves.


Pssm-ID: 381566  Cd Length: 56  Bit Score: 38.97  E-value: 1.78e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1039751981  34 NSNERRRMQSINAGFQSLKTLIPHT-DGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd19723     6 NERERNRVKLVNLGFATLREHVPNGrANKKMSKVETLRSAVEYIRQLQQ 54
bHLHzip_MGA cd18911
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and ...
30-94 2.82e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins; MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites.


Pssm-ID: 381481  Cd Length: 65  Bit Score: 38.61  E-value: 2.82e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039751981  30 REIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLK 94
Cdd:cd18911     1 RRTHTANERRRRNEMRDLFEKLKRTLGLHNLPKVSKYYILKQAFEEIQGLTDQADRLIGQKTLLT 65
bHLHzip_SREBP2 cd18922
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
29-94 3.00e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 2 (SREBP2) and similar proteins; SREBP2, also termed Class D basic helix-loop-helix protein 2 (bHLHd2), or sterol regulatory element-binding transcription factor 2 (SREBF2), is a member of a family of bHLHzip transcription factors that recognize sterol regulatory element 1 (SRE-1). It acts as a transcription activator of cholesterol biosynthesis.


Pssm-ID: 381492 [Multi-domain]  Cd Length: 77  Bit Score: 38.78  E-value: 3.00e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGeKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLK 94
Cdd:cd18922     6 RRTTHNIIEKRYRSSINDKIIELKDLVMGTDA-KMHKSGVLRKAIDYIKYLQQVNHKLRQENMALK 70
bHLH_SOHLH_like cd19683
basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific ...
29-76 3.47e-04

basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein (SOHLH) family and similar proteins; The SOHLH family includes two bHLH transcription factors, SOHLH1 and SOHLH2. They are specifically in spermatogonia and oocytes and essential for early spermatogonial and oocyte differentiation. The family also includes transcription factor-like 5 protein (TCFL5) and similar proteins. TCFL5, also termed Cha transcription factor, or HPV-16 E2-binding protein 1 (E2BP-1), is a bHLH transcription factor that plays a crucial role in spermatogenesis. It regulates cell proliferation or differentiation of cells through binding to a specific DNA sequence like other bHLH molecules.


Pssm-ID: 381526  Cd Length: 58  Bit Score: 38.10  E-value: 3.47e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDgEKLSKAAILQQTAEYI 76
Cdd:cd19683     2 SRERHNAKERQRRERIKIACDQLRKLVPGCS-RKTDKATVFEFTVAYI 48
bHLH_TS_NGN2_ATOH4 cd19717
basic helix-loop-helix (bHLH) domain found in neurogenin-2 (NGN-2) and similar proteins; NGN-2, ...
26-81 4.65e-04

basic helix-loop-helix (bHLH) domain found in neurogenin-2 (NGN-2) and similar proteins; NGN-2, also termed Class A basic helix-loop-helix protein 8 (bHLHa8), or protein atonal homolog 4 (ATOH4), is a neural-specific bHLH transcription factor required for sensory neurogenesis. It activates transcription by binding to the E box (5'-CANNTG-3').


Pssm-ID: 381560 [Multi-domain]  Cd Length: 69  Bit Score: 38.08  E-value: 4.65e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039751981  26 RRIRREIANSNERRRMQSINAGFQSLKTLIPH-TDGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd19717     7 KKTRRVKANNRERNRMHNLNAALDSLREVLPTfPEDAKLTKIETLRFAHNYIWALSE 63
bHLH_TS_ASCL2_Mash2 cd19743
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 2 (ASCL-2) and ...
34-80 6.88e-04

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 2 (ASCL-2) and similar proteins; ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves.


Pssm-ID: 381586  Cd Length: 64  Bit Score: 37.25  E-value: 6.88e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1039751981  34 NSNERRRMQSINAGFQSLKTLIPHTD-GEKLSKAAILQQTAEYIFSLE 80
Cdd:cd19743     8 NERERNRVKLVNLGFAALRQHVPQGGaSKKMSKVETLRSAVEYIRALQ 55
bHLH_TS_ceHLH13_like cd11416
basic helix-loop-helix (bHLH) domain found in Caenorhabditis elegans Helix-loop-helix protein ...
27-76 7.69e-04

basic helix-loop-helix (bHLH) domain found in Caenorhabditis elegans Helix-loop-helix protein 13 (HLH13) and similar proteins; Caenorhabditis elegans HLH13, also termed Fer3-like protein, or nephew of atonal 3, is a bHLH transcription factor that plays a role in the negative regulation of exit from L1 arrest and dauer diapause dependent on IIS signaling (insulin and insulin-like growth factor (IGF) signaling).


Pssm-ID: 381422 [Multi-domain]  Cd Length: 63  Bit Score: 37.10  E-value: 7.69e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1039751981  27 RIRREIANSNERRRMQSINAGFQSLKTLIPHTDGEK-LSKAAILQQTAEYI 76
Cdd:cd11416     3 KVQRHAANIRERKRMLSINSAFEELRCHVPTFPYEKrLSKIDTLRLAIAYI 53
bHLH_TS_NeuroD1 cd19719
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 1 (NeuroD1) ...
22-81 8.40e-04

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 1 (NeuroD1) and similar proteins; NeuroD1, also termed Class A basic helix-loop-helix protein 3 (bHLHa3), is a neuronal bHLH transcription factor involved in the development and maintenance of the endocrine pancreas and neuronal elements. It acts as an essential regulator of glutamatergic neuronal differentiation. Loss of NeuroD1 causes ataxia, cerebellar hypoplasia, sensorineural deafness, and severe retinal dystrophy in mice.


Pssm-ID: 381562  Cd Length: 86  Bit Score: 37.85  E-value: 8.40e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039751981  22 RDQERRIRREIANSNERRRMQSINAGFQSLKTLIP-HTDGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd19719    21 RLERFKMRRMKANARERNRMHGLNAALDNLRKVVPcYSKTQKLSKIETLRLAKNYIWALSE 81
bHLH_TS_scleraxis cd18951
basic helix-loop-helix (bHLH) domain found in scleraxis and similar proteins; Scleraxis, also ...
29-79 9.90e-04

basic helix-loop-helix (bHLH) domain found in scleraxis and similar proteins; Scleraxis, also termed SCX, or Class A basic helix-loop-helix protein 41 (bHLHa41), or Class A basic helix-loop-helix protein 48 (bHLHa48), is a bHLH transcription factor that is expressed in sclerotome limb bud cranial and body wall mesenchyme, pericardium and heart valves, ligaments and tendons. It is required for tendon formation ligaments, connective tissue, the diaphragm, and testis development. Scleraxis plays a central role in promoting fibroblast proliferation and matrix synthesis during the embryonic development of tendons.


Pssm-ID: 381521 [Multi-domain]  Cd Length: 68  Bit Score: 37.06  E-value: 9.90e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGE-KLSKAAILQQTAEYIFSL 79
Cdd:cd18951     4 QRHTANARERDRTNSVNTAFTALRTLIPTEPADrKLSKIETLRLASSYISHL 55
bHLH_TS_MYOD1_Myf3 cd18936
basic helix-loop-helix (bHLH) domain found in myoblast determination protein 1 (MYOD1) and ...
29-80 1.36e-03

basic helix-loop-helix (bHLH) domain found in myoblast determination protein 1 (MYOD1) and similar proteins; MYOD1, also termed Class C basic helix-loop-helix protein 1 (bHLHc1), or myogenic factor 3 (Myf-3), is a bHLH transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with Myf-5 and MYOG, MYOD1 co-occupies muscle-specific gene promoter core region during myogenesis.


Pssm-ID: 381506  Cd Length: 61  Bit Score: 36.58  E-value: 1.36e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLE 80
Cdd:cd18936     6 RRKAATMRERRRLSKVNEAFETLKRCTSTNPNQRLPKVEILRNAIRYIESLQ 57
bHLH_TS_TCF21_capsulin cd19704
basic helix-loop-helix (bHLH) domain found in transcription factor 21 (TCF-21) and similar ...
26-81 1.38e-03

basic helix-loop-helix (bHLH) domain found in transcription factor 21 (TCF-21) and similar proteins; TCF-21, also termed capsulin, or Class A basic helix-loop-helix protein 23 (bHLHa23), or epicardin, or podocyte-expressed 1 (Pod-1), is a bHLH transcription factor expressed specifically in mesodermally-derived cells that surround the epithelium of the developing gastrointestinal, genitourinary and respiratory systems during mouse embryogenesis. It may play a role in the specification or differentiation of one or more subsets of epicardial cell types.


Pssm-ID: 381547 [Multi-domain]  Cd Length: 64  Bit Score: 36.72  E-value: 1.38e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039751981  26 RRIRREIANSNERRRMQSINAGFQSLKTLIPHTDGE-KLSKAAILQQTAEYIFSLEQ 81
Cdd:cd19704     1 KQVQRNAANARERARMRVLSKAFSRLKTTLPWVPPDtKLSKLDTLRLASSYIAHLRQ 57
bHLH_TS_musculin cd19703
basic helix-loop-helix (bHLH) domain found in musculin and similar proteins; Musculin, also ...
26-90 1.48e-03

basic helix-loop-helix (bHLH) domain found in musculin and similar proteins; Musculin, also termed activated B-cell factor 1 (ABF-1), or Class A basic helix-loop-helix protein 22 (bHLHa22), is a bHLH transcription factor expressed in activated B lymphocytes. It acts as a transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. Musculin may play a role in regulating antigen-dependent B-cell differentiation. The mouse homolog, musculin, is suggested to be a repressor of myogenesis that is expressed in developing muscle and in the spleen. Musculin heterodimerizes with products of the E2A gene.


Pssm-ID: 381546 [Multi-domain]  Cd Length: 66  Bit Score: 36.66  E-value: 1.48e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039751981  26 RRIRREIANSNERRRMQSINAGFQSLKTLIPHTDGE-KLSKAAILQQTAEYIFSLEQektrLLQQN 90
Cdd:cd19703     1 KQSQRNAANARERARMRVLSKAFSRLKTSLPWVPPDtKLSKLDTLRLASSYIAHLRQ----LLQED 62
bHLHzip_N-Myc_like cd11456
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins; N-Myc, ...
29-100 1.79e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins; N-Myc, also termed Class E basic helix-loop-helix protein 37 (bHLHe37), is a bHLHZip proto-oncogene protein that positively regulates the transcription of MYCNOS in neuroblastoma cells. It is also essential during embryonic development. N-Myc has a critical role in regulating the switch between proliferation and differentiation of progenitor cells. It binds DNA as a heterodimer with MAX. The family also includes S-Myc, encoded by rat or mouse intronless myc gene, which has apoptosis-inducing activity.


Pssm-ID: 381462 [Multi-domain]  Cd Length: 87  Bit Score: 36.80  E-value: 1.79e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPH-TDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQEL 100
Cdd:cd11456     5 RRRNHNILERQRRNDLRSSFLTLRDHVPElVKNEKAAKVVILKKATEYVHSLQAEEQKLLLEKEKLQARQQQL 77
bHLHzip_c-Myc cd11458
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in c-Myc and similar proteins; c-Myc, ...
25-100 1.99e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in c-Myc and similar proteins; c-Myc, also termed Myc proto-oncogene protein, or Class E basic helix-loop-helix protein 39 (bHLHe39), or transcription factor p64, a bHLHZip proto-oncogene protein that functions as a transcription factor, which binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. It activates the transcription of growth-related genes.


Pssm-ID: 381464 [Multi-domain]  Cd Length: 84  Bit Score: 36.78  E-value: 1.99e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039751981  25 ERRIRREIANSNERRRMQSINAGFQSLKTLIPH-TDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQEL 100
Cdd:cd11458     1 EENDKRRTHNVLERQRRNELKLSFFALRDQIPEvANNEKAPKVVILKKATEYILSMQADEQRLISEKEQLRRRREQL 77
bHLHzip_scHMS1_like cd11399
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae transcription ...
62-94 2.09e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae transcription factor HMS1 and similar proteins; HMS1, also termed high-copy MEP suppressor protein 1, is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation.


Pssm-ID: 381405 [Multi-domain]  Cd Length: 96  Bit Score: 36.68  E-value: 2.09e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1039751981  62 KLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLK 94
Cdd:cd11399    57 KLNKATILSKATEYIRHLEKKNKRLSRENASLR 89
bHLH_TS_HAND1 cd18952
basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed ...
29-76 2.59e-03

basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 1 (HAND1) and similar proteins; HAND1, also termed Class A basic helix-loop-helix protein 27 (bHLHa27), or extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1 (eHAND), is a bHLH transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis.


Pssm-ID: 381522 [Multi-domain]  Cd Length: 60  Bit Score: 35.77  E-value: 2.59e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGE-KLSKAAILQQTAEYI 76
Cdd:cd18952     2 RKGAGPKKERRRTESINSAFAELRECIPNVPADtKLSKIKTLRLATSYI 50
bHLHzip_MITF_like cd11397
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the microphthalmia-associated ...
27-89 2.85e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the microphthalmia-associated transcription factor family (MITF) family; The MITF (also known as microphthalmia-TFE, or MiT) family is a small family that contain a basic helix loop helix domain associated with a leucine zipper (bHLHZip). The MITF family comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF family can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381403  Cd Length: 69  Bit Score: 35.73  E-value: 2.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039751981  27 RIRREIANSNERRRMQSINAGFQSLKTLIPHTDGE--KLSKAAILQQTAEYIFSLEQEKTRLLQQ 89
Cdd:cd11397     3 RQKKDNHNMIERRRRFNINDRIKELGTLLPKSNDPdmRWNKGTILKASVDYIRKLQKEQERLRQL 67
bHLH_TS_musculin_like cd11423
basic helix-loop-helix (bHLH) domain found in musculin, transcription factor 21 (TCF-21) and ...
29-81 2.93e-03

basic helix-loop-helix (bHLH) domain found in musculin, transcription factor 21 (TCF-21) and similar proteins; The family includes two bHLH transcription factors, musculin and transcription factor 21 (TCF-21). Musculin, also termed activated B-cell factor 1 (ABF-1), or Class A basic helix-loop-helix protein 22 (bHLHa22), is a bHLH transcription factor expressed in activated B lymphocytes. It acts as a transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. Musculin may play a role in regulating antigen-dependent B-cell differentiation. The mouse homolog, musculin, is suggested to be a repressor of myogenesis that is expressed in developing muscle and in the spleen. TCF-21, also termed capsulin, or Class A basic helix-loop-helix protein 23 (bHLHa23), or epicardin, or podocyte-expressed 1 (Pod-1), is a bHLH transcription factor expressed specifically in mesodermally-derived cells that surround the epithelium of the developing gastrointestinal, genitourinary and respiratory systems during mouse embryogenesis. It may play a role in the specification or differentiation of one or more subsets of epicardial cell types.


Pssm-ID: 381429 [Multi-domain]  Cd Length: 56  Bit Score: 35.55  E-value: 2.93e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHT-DGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd11423     1 QRNAANARERARMRVLSKAFSRLKTTLPWVpPDTKLSKLDTLRLAASYIAHLRQ 54
bHLH_TS_MRF cd11411
basic helix-loop-helix (bHLH) domain found in myogenic regulatory factor (MRF) family; MRFs ...
29-80 2.98e-03

basic helix-loop-helix (bHLH) domain found in myogenic regulatory factor (MRF) family; MRFs are a family of muscle-specific bHLH transcription proteins (MyoD, Myf5, Mrf4 and MyoG) that plays an essential role in regulating skeletal muscle development and growth. MRFs are capable of binding to E-box motifs as a heterodimer with E-proteins to regulate transcription expression.


Pssm-ID: 381417  Cd Length: 56  Bit Score: 35.20  E-value: 2.98e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLE 80
Cdd:cd11411     2 RRKAATMRERRRLKKVNEAFEALKRCTSANPNQRLPKVEILRNAIEYIESLQ 53
bHLH_AtORG2_like cd18914
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana OBP3-responsive gene 2 ...
29-97 3.14e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana OBP3-responsive gene 2 (ORG2), 3 (ORG3) and similar proteins; The family includes ORG2 (also termed AtbHLH38, or EN 8) and ORG3 (also termed AtbHLH39, or EN 9), both of which act as bHLH transcription factors.


Pssm-ID: 381484 [Multi-domain]  Cd Length: 77  Bit Score: 35.74  E-value: 3.14e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGE-KLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFI 97
Cdd:cd18914     1 KKLLHNDVERQRRQEMASLFSSLRSLLPLQYIKgKLSVSDHVDEAVNYIKELQEKIKELSEKRDELLKLI 70
bHLH_TS_Myf5 cd18937
basic helix-loop-helix (bHLH) domain found in myogenic factor 5 (Myf-5) and similar proteins; ...
29-81 3.30e-03

basic helix-loop-helix (bHLH) domain found in myogenic factor 5 (Myf-5) and similar proteins; Myf-5, also termed Class C basic helix-loop-helix protein 2 (bHLHc2), is a nuclear bHLH transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle specification and differentiation. It also acts as an RNA-binding protein which enhances Ccnd1/Cyclin D1 mRNA translation during myogenesis.


Pssm-ID: 381507  Cd Length: 64  Bit Score: 35.49  E-value: 3.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd18937     2 RRKAATMRERRRLKKVNQAFETLKRCTTSNPNQRLPKVEILRNAIRYIESLQD 54
bHLH_TS_ASCL1_Mash1 cd19742
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 1 (ASCL-1) and ...
34-81 3.47e-03

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 1 (ASCL-1) and similar proteins; ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete scute homolog 1 (Mash1), is a neural-specific bHLH transcription factor that is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system.


Pssm-ID: 381585  Cd Length: 71  Bit Score: 35.50  E-value: 3.47e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1039751981  34 NSNERRRMQSINAGFQSLKTLIPH-TDGEKLSKAAILQQTAEYIFSLEQ 81
Cdd:cd19742    10 NERERNRVKLVNMGFATLREHVPNgAANKKMSKVETLRSAVEYIRALQQ 58
bHLH_AtbHLH_like cd11393
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription ...
34-86 3.62e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses.


Pssm-ID: 381399  Cd Length: 53  Bit Score: 34.85  E-value: 3.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039751981  34 NSNERRRMQSINAGFQSLKTLIPHtdGEKLSKAAILQQTAEYIFSLEQEKTRL 86
Cdd:cd11393     2 SIAERKRREKINERIRALRSLVPN--GGKTDKASILDEAIEYIKFLQEQVKVL 52
bHLH_AtAIG1_like cd11455
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein AIG1 and similar ...
37-82 3.84e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein AIG1 and similar proteins; AIG1, also termed AtbHLH32, or EN 54, or protein target of MOOPTEROS 5, is a transcription factor required for MONOPTEROS-dependent root initiation in embryo.


Pssm-ID: 381461  Cd Length: 80  Bit Score: 35.73  E-value: 3.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1039751981  37 ERRRMQSINAGFQSLKTLIPHTDgeKLSKAAILQQTAEYIFSLEQE 82
Cdd:cd11455    15 ERRRRERINSHLATLRTLLPNLS--KTDKASLLAEVVQHVKELKRQ 58
bHLH_PAS cd11391
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain family; bHLH-PAS domain has been found ...
30-76 3.91e-03

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain family; bHLH-PAS domain has been found in a large group of bHLH transcription regulators that are involved in gene expression responding to environmental change and controlling aspects of neural development, including proteins from aryl hydrocarbon receptor nuclear translocator (ARNT) family, hypoxia-inducible factor (HIF) family, aryl hydrocarbon receptor (AhR) family, neuronal PAS domain-containing protein (NPAS) family, Circadian locomotor output cycles protein kaput (CLOCK)-like family, and single-minded (SIM) family. bHLH-PAS transcriptional regulatory factors have a bHLH DNA-binding domain followed by two PAS domains and a C-terminal activation or repression domain. bHLH-PAS family members can be divided into class I and class II based on their dimerization partner. bHLH-PAS class I factors include AhR, HIF and SIM. The best characterized bHLH-PAS Class II protein is the ubiquitous ARNT. Some members of bHLH-PAS family act as transcriptional coactivators (such as NCoA) that lack the ability to dimerize and bind DNA.


Pssm-ID: 381397 [Multi-domain]  Cd Length: 55  Bit Score: 34.86  E-value: 3.91e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1039751981  30 REIANSNERRRMQSINAGFQSLKTLIP--HTDGEKLSKAAILQQTAEYI 76
Cdd:cd11391     1 REKSREAAKKRRDKENAEISELASLLPlpPAVGSKLDKLSVLRLAVAYL 49
bHLH_TS_OLIG2_like cd19725
basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factors, Oligo2, ...
34-83 4.30e-03

basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factors, Oligo2, Oligo3 and similar proteins; The family includes two bHLH transcription factors, Oligo2 and Oligo3. Oligo2, also termed Class B basic helix-loop-helix protein 1 (bHLHb1), or Class E basic helix-loop-helix protein 19 (bHLHe19), or protein kinase C-binding protein 2, or protein kinase C-binding protein RACK17, is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. It cooperates with OLIG1 to establish the MN progenitors (pMN) domain of the embryonic neural tube. Oligo3, also termed Class B basic helix-loop-helix protein 7 (bHLHb7), or Class E basic helix-loop-helix protein 20 (bHLHe20), is expressed in the ventricular zone of the dorsal alar plate of the hindbrain and involved in regulating the development of dorsal and ventral spinal cord. It may determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.


Pssm-ID: 381568  Cd Length: 63  Bit Score: 35.29  E-value: 4.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039751981  34 NSNERRRMQSINAGFQSLKTLIPHTDG---EKLSKAAILQQTAEYIF----SLEQEK 83
Cdd:cd19725     6 NSRERKRMHDLNSALDGLREVMPYAHGpsvRKLSKIATLLLARNYILmltnSLEEMK 62
bHLH_TS_OLIG1 cd18942
basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 1 (Oligo1) ...
23-87 5.62e-03

basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 1 (Oligo1) and similar proteins; Oligo1, also termed Class B basic helix-loop-helix protein 6 (bHLHb6), or Class E basic helix-loop-helix protein 21 (bHLHe21), is a bHLH transcription factor that promotes formation and maturation of oligodendrocytes, especially within the brain.


Pssm-ID: 381512  Cd Length: 75  Bit Score: 34.97  E-value: 5.62e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039751981  23 DQERRIRREIaNSNERRRMQSINAGFQSLKTLI-PH-------TDGEKLSKAAILQQTAEYIFSLE---QEKTRLL 87
Cdd:cd18942     1 EEQQQLRRKI-NSRERKRMQDLNLAMDALREVIlPYsaahcqsSPGRKLSKIATLLLARNYILLLGsslQELRRLL 75
bHLHzip_MGA_like cd19682
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) ...
30-86 5.74e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) family; The MGA family includes MGA, Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins. MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites. spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381525 [Multi-domain]  Cd Length: 65  Bit Score: 34.94  E-value: 5.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039751981  30 REIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRL 86
Cdd:cd19682     1 RLRHKKRERERRSELRELFDKLKQLLGLDSDEKASKLAVLTEAIEEIQQLKREEDEL 57
bHLH_TS_dAS-C_like cd19744
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex ...
34-81 7.09e-03

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex (AS-C) proteins and similar proteins; Drosophila melanogaster AS-C proteins includes lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation.


Pssm-ID: 381587 [Multi-domain]  Cd Length: 67  Bit Score: 34.49  E-value: 7.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751981  34 NSNERRRMQSINAGFQSLKTLIPHTDGE------------KLSKAAILQQTAEYIFSLEQ 81
Cdd:cd19744     6 NARERNRVKQVNNGFAILRQHIPQSVIEdltagggrgkskKLSKVDTLRMAVEYIRRLQK 65
bHLHzip_Mnt cd11402
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar ...
30-100 7.30e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins; Mnt, also termed Class D basic helix-loop-helix protein 3 (bHLHd3), or Myc antagonist MNT, or protein ROX, is a bHLHZip transcriptional repressor that binds DNA as a heterodimer with MAX. It binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'. Mnt has an important role as an antagonist and regulator of Myc activities and it is a potential tumor suppressor. Mnt is ubiquitously expressed. Mnt-deficient mice shown to exhibit early postnatal lethality.


Pssm-ID: 381408 [Multi-domain]  Cd Length: 77  Bit Score: 34.99  E-value: 7.30e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039751981  30 REIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQEL 100
Cdd:cd11402     3 REVHNKLEKNRRAHLKECFETLKRQIPNLDDKKTSNLNILRSALRYIQILKRKEKEYEHEMERLAREKIAL 73
bHLH_TS_Mesp_like cd11425
basic helix-loop-helix (bHLH) domain found in mesoderm posterior protein (Mesp) family; Mesp, ...
29-88 8.00e-03

basic helix-loop-helix (bHLH) domain found in mesoderm posterior protein (Mesp) family; Mesp, a bHLH tissue specific transcription factor, acts as a key regulator of the cardiovascular transcriptional network by inducing directly and/or indirectly the expression of the majority of key cardiovascular transcription factors. The Mesp family includes two bHLH transcription factors, Mesp1 and Mesp2. Mesp1, also termed Class C basic helix-loop-helix protein 5 (bHLHc5), promotes cardiovascular differentiation during embryonic development and embryonic stem cell differentiation. Mesp2, also termed Class C basic helix-loop-helix protein 6 (bHLHc6), plays an important role in somitogenesis. The family also includes mesogenin-1 (Msgn1) and similar proteins. Msgn1, also termed paraxial mesoderm-specific mesogenin1, or pMesogenin1 (pMsgn1), is a bHLH transcription factor required for maturation and segmentation of paraxial mesoderm. It may regulate the expression of T-box transcription factors essential for mesoderm formation and differentiation.


Pssm-ID: 381431 [Multi-domain]  Cd Length: 59  Bit Score: 34.39  E-value: 8.00e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039751981  29 RREIANSNERRRMQSINAGFQSLKTLIPHT---DGEKLSKAAILQQTAEYIFSLeqekTRLLQ 88
Cdd:cd11425     1 QRQLANERERLRMRTLADALGELRQHLPPSvapKGKRLSKIQTLKYAIRYIGYL----GNVLQ 59
bHLHzip_USF2 cd18923
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) ...
20-96 8.09e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins; USF2, also termed Class B basic helix-loop-helix protein 12 (bHLHb12), or major late transcription factor 2, or FOS-interacting protein (FIP), or upstream transcription factor 2, is a bHLHzip transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.


Pssm-ID: 381493  Cd Length: 80  Bit Score: 34.68  E-value: 8.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751981  20 TQRDQERRIRReiaNSNERRRMQSINAGFQSLKTLIPHTDGEK----LSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKR 95
Cdd:cd18923     2 TPRDERRRAQH---NEVERRRRDKINNWIVQLSKIIPDCNTDNsktgASKGGILSKACDYIRELRQTNQRMQETYKEAER 78

                  .
gi 1039751981  96 F 96
Cdd:cd18923    79 L 79
bHLH-O_HERP_like cd11389
basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES) ...
37-82 8.27e-03

basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES)-related repressor protein (HERP)-like family; The HERP-like family includes bHLH-O transcriptional regulators that are related to the Drosophila hairy and Enhancer-of-split proteins. They contain a basic helix-loop-helix (bHLH) domain with an invariant glycine residue in its basic region, an orange domain in the central region and YXXW sequence motif at its C-terminal region. HERP proteins (HEY1, HEY2 and HEYL) act as downstream effectors of Notch signaling. They are involved in cardiovascular development and have roles in somitogenesis, myogenesis and gliogenesis. Hairy and enhancer of split-related protein HELT is a transcriptional repressor expressed in the developing central nervous system. It binds preferentially to the canonical E box sequence 5'-CACGCG-3' and regulates neuronal differentiation and/or identity. Differentially expressed in chondrocytes proteins, DEC1 and DEC2, are widely expressed in both embryonic and adult tissues and have been implicated in apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in various cancers. Drosophila melanogaster protein clockwork orange (Cwo) is also included in this family. It is involved in the regulation of Drosophila circadian rhythms. It functions as both an activator and a repressor of clock gene expression.


Pssm-ID: 381395 [Multi-domain]  Cd Length: 55  Bit Score: 34.22  E-value: 8.27e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039751981  37 ERRRMQSINAGFQSLKTLIP----HTDGEKLSKAAILQQTAEYIFSLEQE 82
Cdd:cd11389     5 EKRRRDRINESLAELRRLVPearkSKGSGKLEKAEILEMTLQHLKALQSS 54
bHLHzip_L-Myc cd11457
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in L-Myc and similar proteins; L-Myc, ...
23-103 9.65e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in L-Myc and similar proteins; L-Myc, also termed Class E basic helix-loop-helix protein 38 (bHLHe38), or protein L-Myc-1, or V-myc myelocytomatosis viral oncogene homolog, is a bHLHZip oncoprotein belonging to the Myc oncogene protein family. It binds DNA as a heterodimer with MAX. L-Myc is co-expressed with another Myc family member and has weaker transformation/transactivation activities. L-Myc knockout mouse did not exhibit any phenotypic abnormalities.


Pssm-ID: 381463 [Multi-domain]  Cd Length: 89  Bit Score: 34.77  E-value: 9.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751981  23 DQERRIRREIANSNERRRMQSINAGFQSLKTLIPH-TDGEKLSKAAILQQTAEYIFSL-------EQEKTRLLQQNTQLK 94
Cdd:cd11457     1 DTEDVAKRKNHNFLERKRRNDLRSRFLALRDEVPGlASCSKTPKVVILSKATEYLRGLvsaerrmAAEKRQLKSRQQQLL 80

                  ....*....
gi 1039751981  95 RFIQELSGS 103
Cdd:cd11457    81 RRIAQLKGR 89
bHLH_TS_bHLHe22_like cd11468
basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein bHLHe22, ...
30-76 9.78e-03

basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein bHLHe22, bHLHe23 and similar proteins; The family includes two OLIG-related bHLH transcription factors, bHLHe22 and bHLHe23. bHLHe22, also termed Class B basic helix-loop-helix protein 5 (bHLHb5), or trinucleotide repeat-containing gene 20 protein, is a neural-specific transcriptional repressor that is expressed in both excitatory (unipolar brush cells) and inhibitory neurons (cartwheel cells) of the dorsal cochlear nucleus (DCN) during development. It is important for the proper development and/or survival of a number of neural cell types. bHLHe23, also termed Class B basic helix-loop-helix protein 4 (bHLHb4), is expressed in rod bipolar cells and is required for rod bipolar cell maturation. bHLHe23 have roles in spinal interneuron differentiation by mechanisms linked to the Notch signaling pathway. It modulates the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types.


Pssm-ID: 381474  Cd Length: 62  Bit Score: 34.04  E-value: 9.78e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039751981  30 REIANSNERRRMQSINAGFQSLKTLIPHTDG---EKLSKAAILQQTAEYI 76
Cdd:cd11468     1 RLSINARERRRMHDLNDALDDLRAVIPYAHSpsvRKLSKIATLLLAKNYI 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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