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H2AC20 H2A clustered histone 20 [ Homo sapiens (human) ]

Gene ID: 8338, updated on 3-Nov-2024

Summary

Official Symbol
H2AC20provided by HGNC
Official Full Name
H2A clustered histone 20provided by HGNC
Primary source
HGNC:HGNC:4738
See related
Ensembl:ENSG00000184260 MIM:602797; AllianceGenome:HGNC:4738
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2A; H2A/q; H2AFQ; H2A-GL101; HIST2H2AC
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H2AC20 in Genome Data Viewer
Location:
1q21.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (149886918..149887411)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (149011056..149011549)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149858468..149858961)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H4 clustered histone 15 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149824048-149824725 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149824726-149825404 Neighboring gene H3 clustered histone 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1655 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:149856835-149857428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1659 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1660 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1661 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1662 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149859809-149860403 Neighboring gene H2B clustered histone 21 Neighboring gene H2A clustered histone 21 Neighboring gene uncharacterized LOC124904412

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat activated transcription facilitates removal of histones H2A and H2B at the LTR, and the FACT complex, at least consisting of SPT16 and SSRP1, may be responsible for their removal PubMed
tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC74460

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
part_of nucleosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H2A type 2-C
Names
H2A histone family, member Q
histone 2, H2ac
histone H2A-GL101
histone H2A/q
histone IIa
histone cluster 2 H2A family member c
histone cluster 2, H2ac

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003517.3NP_003508.1  histone H2A type 2-C

    See identical proteins and their annotated locations for NP_003508.1

    Status: REVIEWED

    Source sequence(s)
    AC239868
    Consensus CDS
    CCDS937.1
    UniProtKB/Swiss-Prot
    Q16777, Q6DRA7, Q8IUE5
    UniProtKB/TrEMBL
    B2R5B3
    Related
    ENSP00000332194.3, ENST00000331380.4
    Conserved Domains (1) summary
    PTZ00017
    Location:1129
    PTZ00017; histone H2A; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    149886918..149887411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    149011056..149011549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)