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H2AC4 H2A clustered histone 4 [ Homo sapiens (human) ]

Gene ID: 8335, updated on 4-Feb-2024

Summary

Official Symbol
H2AC4provided by HGNC
Official Full Name
H2A clustered histone 4provided by HGNC
Primary source
HGNC:HGNC:4734
See related
Ensembl:ENSG00000278463 MIM:602795; AllianceGenome:HGNC:4734
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2A/m; H2AC8; H2AFM; HIST1H2AB
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H2AC4 in Genome Data Viewer
Location:
6p22.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26033092..26033618, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (25899048..25899577, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26033320..26033846, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24178 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26027580-26028165 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26028166-26028750 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:26028751-26029336 Neighboring gene H4 clustered histone 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24180 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26033291-26033920 Neighboring gene H3 clustered histone 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24184 Neighboring gene H2B clustered histone 3 Neighboring gene H2A clustered histone 5, pseudogene

Genomic regions, transcripts, and products

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chromatin organization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in heterochromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to CENP-A containing chromatin NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of CENP-A containing nucleosome IPI
Inferred from Physical Interaction
more info
PubMed 
located_in extracellular exosome HDA PubMed 
part_of nucleosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nucleosome IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H2A type 1-B/E
Names
H2A histone family, member M
histone 1, H2ab
histone H2A/m
histone cluster 1 H2A family member b
histone cluster 1, H2ab

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003513.3NP_003504.2  histone H2A type 1-B/E

    See identical proteins and their annotated locations for NP_003504.2

    Status: REVIEWED

    Source sequence(s)
    U91328
    Consensus CDS
    CCDS4574.1
    UniProtKB/Swiss-Prot
    P04908, P28001, Q76P63
    UniProtKB/TrEMBL
    B2R5B6, Q08AJ9
    Related
    ENSP00000483842.2, ENST00000615868.2
    Conserved Domains (1) summary
    PTZ00017
    Location:1130
    PTZ00017; histone H2A; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    26033092..26033618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    25899048..25899577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)