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H2ac4 H2A clustered histone 4 [ Mus musculus (house mouse) ]

Gene ID: 319172, updated on 8-Dec-2022

Summary

Official Symbol
H2ac4provided by MGI
Official Full Name
H2A clustered histone 4provided by MGI
Primary source
MGI:MGI:2448306
See related
Ensembl:ENSMUSG00000061615 AllianceGenome:MGI:2448306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H2A.1; H2a-53; Hist1h2ab
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H2ac4 in Genome Data Viewer
Location:
13; 13 A3.1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (23935071..23935575)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23751088..23751592)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene H2A clustered histone 5, pseudogene Neighboring gene H2B clustered histone 3 Neighboring gene H3 clustered histone 2 Neighboring gene H4 clustered histone 2

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein localization to CENP-A containing chromatin NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of CENP-A containing nucleosome ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone H2A type 1-B
Names
Histone H2A type 1-B
histone 1, H2ab
histone H2A type 1
histone cluster 1, H2ab

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175660.4NP_783591.2  histone H2A type 1-B

    See identical proteins and their annotated locations for NP_783591.2

    Status: VALIDATED

    Source sequence(s)
    AL590388
    Consensus CDS
    CCDS26364.1
    UniProtKB/Swiss-Prot
    C0HKE1, C0HKE2, C0HKE3, C0HKE4, C0HKE5, C0HKE6, C0HKE7, C0HKE8, C0HKE9, Q5SZZ2
    UniProtKB/TrEMBL
    A0A6P5QP89, A0A8C6G9K1, B2RVF0
    Related
    ENSMUSP00000077477.2, ENSMUST00000078369.3
    Conserved Domains (1) summary
    PTZ00017
    Location:1130
    PTZ00017; histone H2A; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    23935071..23935575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)