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FZD1 frizzled class receptor 1 [ Homo sapiens (human) ]

Gene ID: 8321, updated on 13-Mar-2020

Summary

Official Symbol
FZD1provided by HGNC
Official Full Name
frizzled class receptor 1provided by HGNC
Primary source
HGNC:HGNC:4038
See related
Ensembl:ENSG00000157240 MIM:603408
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See FZD1 in Genome Data Viewer
Location:
7q21.13
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (91264433..91271326)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (90893783..90898132)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 14 Neighboring gene VISTA enhancer hs1633 Neighboring gene VISTA enhancer hs1631 Neighboring gene heart enhancer 20 Neighboring gene uncharacterized LOC105375392 Neighboring gene NIPA2 pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The expression of frizzled class receptor 1 (FZD1) gene is upregulated in both Jurkat-Tat101 and Jurkat-Tat72 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ95923, DKFZp564G072

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
Wnt-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Wnt-activated receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Wnt-activated receptor activity TAS
Traceable Author Statement
more info
PubMed 
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Wnt-protein binding NAS
Non-traceable Author Statement
more info
PubMed 
frizzled binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation NAS
Non-traceable Author Statement
more info
PubMed 
Wnt signaling pathway, planar cell polarity pathway TAS
Traceable Author Statement
more info
 
astrocyte-dopaminergic neuron signaling IEA
Inferred from Electronic Annotation
more info
 
autocrine signaling IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin destruction complex disassembly TAS
Traceable Author Statement
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
canonical Wnt signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway involved in osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
hard palate development IEA
Inferred from Electronic Annotation
more info
 
membranous septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
muscular septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of oxidative stress-induced neuron death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
planar cell polarity pathway involved in neural tube closure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
presynapse assembly TAS
Traceable Author Statement
more info
PubMed 
regulation of presynapse assembly IEA
Inferred from Electronic Annotation
more info
 
response to drug IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Wnt signalosome IC
Inferred by Curator
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion HDA PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
frizzled-1
Names
Wnt receptor
frizzled 1, seven transmembrane spanning receptor
frizzled family receptor 1
frizzled homolog 1
frizzled, Drosophila, homolog of, 1
fz-1
fzE1
hFz1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003505.2NP_003496.1  frizzled-1

    See identical proteins and their annotated locations for NP_003496.1

    Status: REVIEWED

    Source sequence(s)
    AB017363, AC084381
    Consensus CDS
    CCDS5620.1
    UniProtKB/Swiss-Prot
    Q9UP38
    Related
    ENSP00000287934.2, ENST00000287934.4
    Conserved Domains (2) summary
    cd07465
    Location:112238
    CRD_FZ1; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 1 (Fz1) receptor
    pfam01534
    Location:310634
    Frizzled; Frizzled/Smoothened family membrane region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    91264433..91271326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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