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Fzd1 frizzled class receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 14362, updated on 8-Feb-2024

Summary

Official Symbol
Fzd1provided by MGI
Official Full Name
frizzled class receptor 1provided by MGI
Primary source
MGI:MGI:1196625
See related
Ensembl:ENSMUSG00000044674 AllianceGenome:MGI:1196625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fz1; FZ-1
Summary
Enables Wnt-protein binding activity. Involved in astrocyte-dopaminergic neuron signaling; negative regulation of oxidative stress-induced neuron death; and regulation of presynapse assembly. Acts upstream of or within several processes, including Wnt signaling pathway; heart morphogenesis; and negative regulation of signal transduction. Predicted to be located in cell surface and neuron projection. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Orthologous to human FZD1 (frizzled class receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Fzd1 in Genome Data Viewer
Location:
5 A1; 5 2.61 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (4803839..4808216, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (4753839..4758216, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12326 Neighboring gene STARR-seq mESC enhancer starr_12327 Neighboring gene STARR-seq mESC enhancer starr_12328 Neighboring gene STARR-seq mESC enhancer starr_12329 Neighboring gene STARR-seq mESC enhancer starr_12330 Neighboring gene predicted gene, 40261 Neighboring gene STARR-seq mESC enhancer starr_12331 Neighboring gene STARR-seq mESC enhancer starr_12332 Neighboring gene STARR-seq mESC enhancer starr_12333 Neighboring gene STARR-seq mESC enhancer starr_12334 Neighboring gene STARR-seq mESC enhancer starr_12336 Neighboring gene predicted gene, 54299 Neighboring gene STARR-seq mESC enhancer starr_12337 Neighboring gene cyclin dependent kinase 14 Neighboring gene STARR-seq mESC enhancer starr_12338 Neighboring gene VISTA enhancer mm49 Neighboring gene predicted gene, 22897 Neighboring gene predicted gene, 54300

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables Wnt receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Wnt receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Wnt-protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables Wnt-protein binding ISO
Inferred from Sequence Orthology
more info
 
enables frizzled binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in autocrine signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell-cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endothelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within endothelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hard palate development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within membranous septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within muscular septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within outflow tract morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mesenchymal stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of presynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of presynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ventricular septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
frizzled-1
Names
frizzled homolog 1
mFz1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021457.3NP_067432.2  frizzled-1 precursor

    See identical proteins and their annotated locations for NP_067432.2

    Status: VALIDATED

    Source sequence(s)
    AK143101, BC053010, BE948559
    Consensus CDS
    CCDS19072.1
    UniProtKB/Swiss-Prot
    O08974, O70421, Q7TS82
    Related
    ENSMUSP00000058629.5, ENSMUST00000054294.7
    Conserved Domains (2) summary
    cd07465
    Location:107233
    CRD_FZ1; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 1 (Fz1) receptor
    cd15247
    Location:294641
    7tmF_FZD1; class F mammalian frizzled subfamily 1, member of 7-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    4803839..4808216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)