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UPL4 ubiquitin-protein ligase 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831758, updated on 18-Sep-2024

Summary

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Official Symbol
UPL4
Official Full Name
ubiquitin-protein ligase 4
Primary source
TAIR:AT5G02880
Locus tag
AT5G02880
See related
Araport:AT5G02880
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F9G14.190; F9G14_190; ubiquitin-protein ligase 4
Summary
encodes a ubiquitin-protein ligase containing a HECT domain. There are six other HECT-domain UPLs in Arabidopsis.
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Genomic context

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Location:
chromosome: 5
Exon count:
16
Sequence:
Chromosome: 5; NC_003076.8 (661936..669124)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L4/L1 family Neighboring gene ncRNA Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene cytochrome P450, family 96, subfamily A, polypeptide 13

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The HECT ubiquitin-protein ligase (UPL) family in Arabidopsis: UPL3 has a specific role in trichome development. Downes BP, et al. Plant J, 2003 Sep. PMID 12969426
  2. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

General gene information

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Homology

NM_120366.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in nucleus ISM
Inferred from Sequence Model
more info
  
part_of ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin-protein ligase 4
NP_195908.1
  • ubiquitin-protein ligase 4 (UPL4); CONTAINS InterPro DOMAIN/s: Armadillo-like helical (InterPro:IPR011989), Armadillo-type fold (InterPro:IPR016024), HECT (InterPro:IPR000569); BEST Arabidopsis thaliana protein match is: HEAT repeat; HECT-domain (ubiquitin-transferase) (TAIR:AT4G38600.1); Has 5635 Blast hits to 5003 proteins in 272 species: Archae - 0; Bacteria - 11; Metazoa - 3196; Fungi - 992; Plants - 513; Viruses - 0; Other Eukaryotes - 923 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    661936..669124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001342678.1 → NP_001331961.1  ubiquitin-protein ligase 4 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UHV4, A0A1P8BFE7

  2. NM_120366.4 → NP_195908.1  ubiquitin-protein ligase 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_195908.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LYZ7
    UniProtKB/TrEMBL
    A0A654FY97
    Conserved Domains (5) summary
    smart00119
    Location:1136 → 1497
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00020
    Location:156 → 264
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    cd00078
    Location:1114 → 1500
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00044
    Location:277 → 303
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:156 → 181
    ARM; armadillo repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LYZ7.1

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