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RBM10 RNA binding motif protein 10 [ Homo sapiens (human) ]

Gene ID: 8241, updated on 5-Jan-2020

Summary

Official Symbol
RBM10provided by HGNC
Official Full Name
RNA binding motif protein 10provided by HGNC
Primary source
HGNC:HGNC:9896
See related
Ensembl:ENSG00000182872 MIM:300080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S1-1; TARPS; GPATC9; ZRANB5; GPATCH9; DXS8237E
Summary
This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]
Expression
Ubiquitous expression in ovary (RPKM 15.6), spleen (RPKM 12.3) and 25 other tissues See more
Orthologs

Genomic context

See RBM10 in Genome Data Viewer
Location:
Xp11.3
Exon count:
25
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (47145196..47186815)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47004617..47046214)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373193 Neighboring gene uncharacterized LOC107985720 Neighboring gene RNA, U12 small nuclear 2, pseudogene Neighboring gene NADH:ubiquinone oxidoreductase subunit B11 Neighboring gene inositol 1,3,4-triphosphate 5/6 kinase pseudogene Neighboring gene ubiquitin like modifier activating enzyme 1 Neighboring gene uncharacterized LOC105373194 Neighboring gene inactivation escape 1 Neighboring gene cyclin dependent kinase 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of RNA binding motif protein 10 (RBM10) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC997, MGC1132, FLJ40796, KIAA0122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
3'-UTR-mediated mRNA stabilization IEA
Inferred from Electronic Annotation
more info
 
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
biological_process ND
No biological Data available
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of alternative mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
RNA-binding protein 10
Names
RNA-binding protein S1-1
epididymis secretory sperm binding protein
g patch domain-containing protein 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012548.1 RefSeqGene

    Range
    4990..46582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204466.2NP_001191395.1  RNA-binding protein 10 isoform 3

    See identical proteins and their annotated locations for NP_001191395.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK292758, AL513366, AW248804, BX537969, DB183041
    Consensus CDS
    CCDS56600.1
    UniProtKB/Swiss-Prot
    P98175
    UniProtKB/TrEMBL
    Q7Z3D7
    Related
    ENSP00000329659.6, ENST00000345781.10
    Conserved Domains (6) summary
    smart00547
    Location:138162
    ZnF_RBZ; Zinc finger domain
    cd12754
    Location:221307
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00025
    Location:140159
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:487550
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:781825
    G-patch; G-patch domain
    cl17169
    Location:67134
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001204467.2NP_001191396.1  RNA-binding protein 10 isoform 4

    See identical proteins and their annotated locations for NP_001191396.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses and alternate splice site in the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AL513366, AW248804, D50912, DB183041
    UniProtKB/Swiss-Prot
    P98175
    Conserved Domains (7) summary
    smart00547
    Location:215239
    ZnF_RBZ; Zinc finger domain
    COG0724
    Location:21232
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12753
    Location:127211
    RRM1_RBM10; RNA recognition motif 1 in vertebrate RNA-binding protein 10 (RBM10)
    cd12754
    Location:298383
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00025
    Location:217236
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:563626
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:857901
    G-patch; G-patch domain
  3. NM_001204468.1NP_001191397.1  RNA-binding protein 10 isoform 5

    See identical proteins and their annotated locations for NP_001191397.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' coding region and initiates translation at an upstream in-frame start codon, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AL513366, AW248804, BX537969, DB183041
    Consensus CDS
    CCDS75969.1
    UniProtKB/TrEMBL
    Q7Z3D7
    Related
    ENSP00000328848.8, ENST00000329236.8
    Conserved Domains (8) summary
    smart00547
    Location:280304
    ZnF_RBZ; Zinc finger domain
    COG0724
    Location:86297
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12753
    Location:192276
    RRM1_RBM10; RNA recognition motif 1 in vertebrate RNA-binding protein 10 (RBM10)
    cd12754
    Location:363449
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    TIGR01661
    Location:201446
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    sd00025
    Location:282301
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam01585
    Location:923967
    G-patch; G-patch domain
    cd16167
    Location:629692
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
  4. NM_005676.5NP_005667.2  RNA-binding protein 10 isoform 1

    See identical proteins and their annotated locations for NP_005667.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AW248804, BC008733, DB183041
    Consensus CDS
    CCDS14274.1
    UniProtKB/Swiss-Prot
    P98175
    UniProtKB/TrEMBL
    A0A0S2Z4W4
    Related
    ENSP00000366829.3, ENST00000377604.8
    Conserved Domains (7) summary
    smart00547
    Location:215239
    ZnF_RBZ; Zinc finger domain
    COG0724
    Location:21232
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12753
    Location:127211
    RRM1_RBM10; RNA recognition motif 1 in vertebrate RNA-binding protein 10 (RBM10)
    cd12754
    Location:298384
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00025
    Location:217236
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:564627
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:858902
    G-patch; G-patch domain
  5. NM_152856.3NP_690595.1  RNA-binding protein 10 isoform 2

    See identical proteins and their annotated locations for NP_690595.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon and uses and alternate splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC003089, DB183041
    Consensus CDS
    CCDS78478.1
    UniProtKB/Swiss-Prot
    P98175
    UniProtKB/TrEMBL
    A0A0S2Z4X1
    Related
    ENSP00000486115.1, ENST00000628161.2
    Conserved Domains (6) summary
    smart00547
    Location:138162
    ZnF_RBZ; Zinc finger domain
    cd12754
    Location:221306
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00025
    Location:140159
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:486549
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:780824
    G-patch; G-patch domain
    cl17169
    Location:67134
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    47145196..47186815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272677.4XP_005272734.1  RNA-binding protein 10 isoform X3

    Conserved Domains (7) summary
    smart00547
    Location:280304
    ZnF_RBZ; Zinc finger domain
    COG0724
    Location:86297
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12753
    Location:192276
    RRM1_RBM10; RNA recognition motif 1 in vertebrate RNA-binding protein 10 (RBM10)
    cd12754
    Location:363448
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00025
    Location:282301
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam01585
    Location:922966
    G-patch; G-patch domain
    cd16167
    Location:628691
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
  2. XM_024452459.1XP_024308227.1  RNA-binding protein 10 isoform X4

    Conserved Domains (7) summary
    smart00547
    Location:215239
    ZnF_RBZ; Zinc finger domain
    COG0724
    Location:21232
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12753
    Location:127211
    RRM1_RBM10; RNA recognition motif 1 in vertebrate RNA-binding protein 10 (RBM10)
    cd12754
    Location:298384
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00029
    Location:217236
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:598661
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:892936
    G-patch; G-patch domain
  3. XM_024452460.1XP_024308228.1  RNA-binding protein 10 isoform X5

    Conserved Domains (7) summary
    smart00547
    Location:215239
    ZnF_RBZ; Zinc finger domain
    COG0724
    Location:21232
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12753
    Location:127211
    RRM1_RBM10; RNA recognition motif 1 in vertebrate RNA-binding protein 10 (RBM10)
    cd12754
    Location:298383
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00029
    Location:217236
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:597660
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:891935
    G-patch; G-patch domain
  4. XM_024452462.1XP_024308230.1  RNA-binding protein 10 isoform X9

    Conserved Domains (6) summary
    smart00547
    Location:138162
    ZnF_RBZ; Zinc finger domain
    cd12754
    Location:221307
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00029
    Location:140159
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:521584
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:815859
    G-patch; G-patch domain
    cl17169
    Location:67134
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. XM_017029884.2XP_016885373.1  RNA-binding protein 10 isoform X11

    Conserved Domains (6) summary
    smart00547
    Location:1236
    ZnF_RBZ; Zinc finger domain
    COG0724
    Location:85190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12754
    Location:95181
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00025
    Location:1433
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam01585
    Location:655699
    G-patch; G-patch domain
    cd16167
    Location:361424
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
  6. XM_024452457.1XP_024308225.1  RNA-binding protein 10 isoform X1

    Conserved Domains (7) summary
    smart00547
    Location:280304
    ZnF_RBZ; Zinc finger domain
    COG0724
    Location:86297
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12753
    Location:192276
    RRM1_RBM10; RNA recognition motif 1 in vertebrate RNA-binding protein 10 (RBM10)
    cd12754
    Location:363449
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00029
    Location:282301
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:663726
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:9571001
    G-patch; G-patch domain
  7. XM_024452458.1XP_024308226.1  RNA-binding protein 10 isoform X2

    Conserved Domains (7) summary
    smart00547
    Location:280304
    ZnF_RBZ; Zinc finger domain
    COG0724
    Location:86297
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12753
    Location:192276
    RRM1_RBM10; RNA recognition motif 1 in vertebrate RNA-binding protein 10 (RBM10)
    cd12754
    Location:363448
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00029
    Location:282301
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:662725
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:9561000
    G-patch; G-patch domain
  8. XM_024452461.1XP_024308229.1  RNA-binding protein 10 isoform X6

    Conserved Domains (6) summary
    smart00547
    Location:203227
    ZnF_RBZ; Zinc finger domain
    cd12754
    Location:286372
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00029
    Location:205224
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:586649
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:880924
    G-patch; G-patch domain
    cl17169
    Location:132199
    RRM_SF; RNA recognition motif (RRM) superfamily
  9. XM_005272678.4XP_005272735.1  RNA-binding protein 10 isoform X7

    Conserved Domains (7) summary
    smart00547
    Location:203227
    ZnF_RBZ; Zinc finger domain
    COG0724
    Location:276381
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12754
    Location:286372
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00025
    Location:205224
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam01585
    Location:846890
    G-patch; G-patch domain
    cd16167
    Location:552615
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    cl17169
    Location:132199
    RRM_SF; RNA recognition motif (RRM) superfamily
  10. XM_005272679.4XP_005272736.1  RNA-binding protein 10 isoform X8

    Conserved Domains (7) summary
    smart00547
    Location:203227
    ZnF_RBZ; Zinc finger domain
    COG0724
    Location:276380
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12754
    Location:286371
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00025
    Location:205224
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam01585
    Location:845889
    G-patch; G-patch domain
    cd16167
    Location:551614
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    cl17169
    Location:132199
    RRM_SF; RNA recognition motif (RRM) superfamily
  11. XM_024452463.1XP_024308231.1  RNA-binding protein 10 isoform X10

    Conserved Domains (5) summary
    smart00547
    Location:1236
    ZnF_RBZ; Zinc finger domain
    cd12754
    Location:95181
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00029
    Location:1433
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:395458
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:689733
    G-patch; G-patch domain
  12. XM_017029885.1XP_016885374.1  RNA-binding protein 10 isoform X12

  13. XM_024452464.1XP_024308232.1  RNA-binding protein 10 isoform X10

    Conserved Domains (5) summary
    smart00547
    Location:1236
    ZnF_RBZ; Zinc finger domain
    cd12754
    Location:95181
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00029
    Location:1433
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:395458
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:689733
    G-patch; G-patch domain
  14. XM_024452465.1XP_024308233.1  RNA-binding protein 10 isoform X13

    Conserved Domains (3) summary
    cd12754
    Location:172
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    cd16167
    Location:286349
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:580624
    G-patch; G-patch domain
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