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Rbm10 RNA binding motif protein 10 [ Mus musculus (house mouse) ]

Gene ID: 236732, updated on 12-May-2024

Summary

Official Symbol
Rbm10provided by MGI
Official Full Name
RNA binding motif protein 10provided by MGI
Primary source
MGI:MGI:2384310
See related
Ensembl:ENSMUSG00000031060 AllianceGenome:MGI:2384310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MINAS-60; E430039K10Rik
Summary
Predicted to enable identical protein binding activity and miRNA binding activity. Acts upstream of or within negative regulation of RNA metabolic process; negative regulation of cell population proliferation; and positive regulation of smooth muscle cell apoptotic process. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; oocyte; and sensory organ. Human ortholog(s) of this gene implicated in TARP syndrome. Orthologous to human RBM10 (RNA binding motif protein 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 28.1), ovary adult (RPKM 27.2) and 28 other tissues See more
Orthologs
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Genomic context

See Rbm10 in Genome Data Viewer
Location:
X A1.3; X 16.11 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (20483596..20517128)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (20617357..20650889)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene upregulated during skeletal muscle growth 5 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5720 Neighboring gene predicted gene, 23628 Neighboring gene NADH:ubiquinone oxidoreductase subunit B11 Neighboring gene ubiquitin-like modifier activating enzyme 1 Neighboring gene STARR-positive B cell enhancer mm9_chrX:20264845-20265145 Neighboring gene cyclin dependent kinase 16

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC7826

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within 3'-UTR-mediated mRNA stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ribosomal large subunit export from nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of vascular associated smooth muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of vascular associated smooth muscle cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of vascular associated smooth muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of vascular associated smooth muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
RNA-binding protein 10
Names
Ribosome biogenesis inhibitor MINAS-60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167775.2NP_001161247.1  RNA-binding protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001161247.1

    Status: VALIDATED

    Source sequence(s)
    AK153736, AL807240
    Consensus CDS
    CCDS53013.1
    UniProtKB/Swiss-Prot
    Q99KG3
    Related
    ENSMUSP00000111033.2, ENSMUST00000115375.8
    Conserved Domains (7) summary
    smart00547
    Location:215239
    ZnF_RBZ; Zinc finger domain
    COG0724
    Location:21232
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12753
    Location:127211
    RRM1_RBM10; RNA recognition motif 1 in vertebrate RNA-binding protein 10 (RBM10)
    cd12754
    Location:298383
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00025
    Location:217236
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:563626
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:857901
    G-patch; G-patch domain
  2. NM_001167776.2NP_001161248.1  RNA-binding protein 10 isoform 3

    See identical proteins and their annotated locations for NP_001161248.1

    Status: VALIDATED

    Source sequence(s)
    AK167666, AL672073, AL807240
    Consensus CDS
    CCDS53014.1
    UniProtKB/Swiss-Prot
    Q99KG3
    Related
    ENSMUSP00000111031.2, ENSMUST00000084383.10
    Conserved Domains (6) summary
    smart00547
    Location:138162
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:140159
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:487550
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:781825
    G-patch; G-patch domain
    cd12754
    Location:221307
    RRM2_RBM10; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 10 (RBM10)
    cl17169
    Location:67134
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. NM_001358903.1NP_001345832.1  RNA-binding protein 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672073, AL807240
    Consensus CDS
    CCDS53013.1
    Related
    ENSMUSP00000136209.2, ENSMUST00000177738.8
    Conserved Domains (7) summary
    smart00547
    Location:215239
    ZnF_RBZ; Zinc finger domain
    COG0724
    Location:21232
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12753
    Location:127211
    RRM1_RBM10; RNA recognition motif 1 in vertebrate RNA-binding protein 10 (RBM10)
    cd12754
    Location:298383
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00025
    Location:217236
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:563626
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:857901
    G-patch; G-patch domain
  4. NM_001358904.1NP_001345833.1  RNA-binding protein 10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672073, AL807240
    Conserved Domains (6) summary
    smart00547
    Location:138162
    ZnF_RBZ; Zinc finger domain
    cd12754
    Location:221306
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00025
    Location:140159
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:486549
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:780824
    G-patch; G-patch domain
    cl17169
    Location:67134
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. NM_001358905.1NP_001345834.1  RNA-binding protein 10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL672073, AL807240
    Conserved Domains (6) summary
    smart00547
    Location:5478
    ZnF_RBZ; Zinc finger domain
    cd12754
    Location:137223
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00025
    Location:5675
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:403466
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:697741
    G-patch; G-patch domain
    cl17169
    Location:150
    RRM_SF; RNA recognition motif (RRM) superfamily
  6. NM_145627.3NP_663602.1  RNA-binding protein 10 isoform 1

    See identical proteins and their annotated locations for NP_663602.1

    Status: VALIDATED

    Source sequence(s)
    AK145991, AL672073, AL807240
    Consensus CDS
    CCDS40885.1
    UniProtKB/Swiss-Prot
    Q3TIY0, Q3U5B8, Q3UKI8, Q80U75, Q8BTP8, Q99KG3
    Related
    ENSMUSP00000111032.2, ENSMUST00000115374.8
    Conserved Domains (8) summary
    smart00547
    Location:215239
    ZnF_RBZ; Zinc finger domain
    COG0724
    Location:21232
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12753
    Location:127211
    RRM1_RBM10; RNA recognition motif 1 in vertebrate RNA-binding protein 10 (RBM10)
    cd12754
    Location:298384
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    TIGR01661
    Location:136381
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    sd00025
    Location:217236
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam01585
    Location:858902
    G-patch; G-patch domain
    cd16167
    Location:564627
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    20483596..20517128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251317.1XP_030107177.1  RNA-binding protein 10 isoform X3

    Conserved Domains (5) summary
    smart00547
    Location:1236
    ZnF_RBZ; Zinc finger domain
    cd12754
    Location:95181
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00029
    Location:1433
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:361424
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:655697
    G-patch; G-patch domain
  2. XM_030251316.1XP_030107176.1  RNA-binding protein 10 isoform X2

    Conserved Domains (6) summary
    smart00547
    Location:5478
    ZnF_RBZ; Zinc finger domain
    cd12754
    Location:137222
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00029
    Location:5675
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:402465
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:696738
    G-patch; G-patch domain
    cl17169
    Location:150
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_006527621.4XP_006527684.1  RNA-binding protein 10 isoform X3

    Conserved Domains (5) summary
    smart00547
    Location:1236
    ZnF_RBZ; Zinc finger domain
    cd12754
    Location:95181
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00029
    Location:1433
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:361424
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:655697
    G-patch; G-patch domain
  4. XM_030251318.1XP_030107178.1  RNA-binding protein 10 isoform X3

    Conserved Domains (5) summary
    smart00547
    Location:1236
    ZnF_RBZ; Zinc finger domain
    cd12754
    Location:95181
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00029
    Location:1433
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:361424
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:655697
    G-patch; G-patch domain
  5. XM_030251319.1XP_030107179.1  RNA-binding protein 10 isoform X4

    Conserved Domains (5) summary
    smart00547
    Location:1236
    ZnF_RBZ; Zinc finger domain
    cd12754
    Location:95180
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00029
    Location:1433
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:360423
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:654696
    G-patch; G-patch domain
  6. XM_030251320.1XP_030107180.1  RNA-binding protein 10 isoform X4

    Conserved Domains (5) summary
    smart00547
    Location:1236
    ZnF_RBZ; Zinc finger domain
    cd12754
    Location:95180
    RRM2_RBM10; RNA recognition motif 2 in vertebrate RNA-binding protein 10 (RBM10)
    sd00029
    Location:1433
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:360423
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:654696
    G-patch; G-patch domain
  7. XM_036161916.1XP_036017809.1  RNA-binding protein 10 isoform X1

    Related
    ENSMUSP00000080738.8, ENSMUST00000082089.14
    Conserved Domains (6) summary
    smart00547
    Location:138162
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:140159
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16167
    Location:487550
    OCRE_RBM10; OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins
    pfam01585
    Location:781825
    G-patch; G-patch domain
    cd12754
    Location:221307
    RRM2_RBM10; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 10 (RBM10)
    cl17169
    Location:67134
    RRM_SF; RNA recognition motif (RRM) superfamily