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NUAK2 NUAK family kinase 2 [ Homo sapiens (human) ]

Gene ID: 81788, updated on 11-Sep-2019

Summary

Official Symbol
NUAK2provided by HGNC
Official Full Name
NUAK family kinase 2provided by HGNC
Primary source
HGNC:HGNC:29558
See related
Ensembl:ENSG00000163545 MIM:608131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNARK
Expression
Broad expression in esophagus (RPKM 10.7), kidney (RPKM 9.5) and 22 other tissues See more
Orthologs

Genomic context

See NUAK2 in Genome Data Viewer
Location:
1q32.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (205302059..205321745, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (205271191..205290883, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene dual serine/threonine and tyrosine protein kinase Neighboring gene ribosomal protein L17 pseudogene 8 Neighboring gene uncharacterized LOC101929459 Neighboring gene transmembrane and coiled-coil domain family 2 Neighboring gene kelch domain containing 8A Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 10 Neighboring gene uncharacterized LOC105371698 Neighboring gene LEMD1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90349, DKFZp434J037, DKFZp686F01113

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose starvation IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
NUAK family SNF1-like kinase 2
Names
NUAK family, SNF1-like kinase, 2
SNF1/AMP activated protein kinase
SNF1/AMP kinase-related kinase
omphalocele kinase 2
NP_112214.3
XP_005245572.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030952.3NP_112214.3  NUAK family SNF1-like kinase 2

    Status: VALIDATED

    Source sequence(s)
    AC098933
    Consensus CDS
    CCDS1453.2
    Related
    ENSP00000356125.5, ENST00000367157.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    205302059..205321745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245515.4XP_005245572.1  NUAK family SNF1-like kinase 2 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:156
    PKc_like; Protein Kinases, catalytic domain
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