NUAK2 NUAK family kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NUAK2provided by HGNC
Official Full Name: NUAK family kinase 2provided by HGNC
Primary source: HGNC:HGNC:29558
See related: Ensembl:ENSG00000163545 MIM:608131; AllianceGenome:HGNC:29558
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ANPH2; SNARK
Summary: Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular response to glucose starvation; protein phosphorylation; and regulation of hippo signaling. Located in nuclear speck. Implicated in anencephaly. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Broad expression in esophagus (RPKM 10.7), kidney (RPKM 9.5) and 22 other tissues See more
Orthologs: all
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Genomic context

Location:: 1q32.1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (205302063..205321745, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (204566371..204586053, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (205271191..205290873, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OTUD7B deubiquitinates and stabilizes YAP1 to upregulate NUAK2 expression, thus accelerating gastric cancer procession.
Title: OTUD7B deubiquitinates and stabilizes YAP1 to upregulate NUAK2 expression, thus accelerating gastric cancer procession.
Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2.
Title: Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2.
Circ_0000033 up-regulates NUAK2 by sequestering miR-378a-3p to promote breast tumorigenesis.
Title: Circ_0000033 up-regulates NUAK2 by sequestering miR-378a-3p to promote breast tumorigenesis.
GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2.
Title: GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2.
NUAK2 silencing inhibits the proliferation, migration and epithelialtomesenchymal transition of cervical cancer cells via upregulating CYFIP2.
Title: NUAK2 silencing inhibits the proliferation, migration and epithelial‑to‑mesenchymal transition of cervical cancer cells via upregulating CYFIP2.
A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling.
Title: A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling.
NUAK2 localization in normal skin and its expression in a variety of skin tumors with YAP.
Title: NUAK2 localization in normal skin and its expression in a variety of skin tumors with YAP.
Data (including data from studies in knockout and transgenic mice) suggest that NUAK2/SNARK is involved in both adipose inflammation and energy metabolism in adipocytes; additionally, genome-wide association studies suggest that 2 SNPs in NUAK2/SNARK (rs4682880, rs4682676) are associated with obesity in women.
Title: Sucrose Nonfermenting-Related Kinase Regulates Both Adipose Inflammation and Energy Homeostasis in Mice and Humans.
miR143 inhibited the proliferation, migration and invasion of the glioblastoma cells by degrading NUAK2 in glioblastoma.
Title: miR-143 inhibits oncogenic traits by degrading NUAK2 in glioblastoma.
Sucrose non-fermenting AMPK related kinase/Pentraxin 3 combined role in immunometabolic signaling and DNA damage response is proposed to accelerate cardiovascular complications in systemic lupus erythematosus patients
Title: Sucrose non-fermenting AMPK related kinase/Pentraxin 3 and DNA damage axis: a gateway to cardiovascular disease in systemic lupus erythematosus among Egyptian patients.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Anencephaly 2 MedGen: C5561945 OMIM: 619452 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2560 (e-PCR)
- UniSTS:37928

MARC_27500-27501:1034792583:1 (e-PCR)
- UniSTS:269104

D8S2279 (e-PCR)
- UniSTS:473907

RH93941 (e-PCR)
- UniSTS:89399

SHGC-76219 (e-PCR)
- UniSTS:33632

D15S1477 (e-PCR)
- UniSTS:474482

RH80030 (e-PCR)
- UniSTS:87680

D11S3114 (e-PCR)
- UniSTS:152207

D11S2612 (e-PCR)
- UniSTS:70572

SHGC-149973 (e-PCR)
- UniSTS:177342

SHGC-76220 (e-PCR)
- UniSTS:24807

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to glucose starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: NUAK family SNF1-like kinase 2

Names: NUAK family, SNF1-like kinase, 2; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2

NP_112214.3

EC 2.7.11.1

XP_005245572.1

EC 2.7.11.1

XP_047287265.1

EC 2.7.11.1

XP_054194905.1

EC 2.7.11.1

XP_054194906.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030952.3 → NP_112214.3 NUAK family SNF1-like kinase 2

Status: VALIDATED

Source sequence(s)

AC098933

Consensus CDS

CCDS1453.3

UniProtKB/Swiss-Prot

Q9H093

UniProtKB/TrEMBL

B4E0Y5

Related

ENSP00000356125.5, ENST00000367157.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

205302063..205321745 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047431309.1 → XP_047287265.1 NUAK family SNF1-like kinase 2 isoform X1

UniProtKB/TrEMBL

Q68E04
XM_005245515.5 → XP_005245572.1 NUAK family SNF1-like kinase 2 isoform X2

UniProtKB/TrEMBL

Q68E04

Conserved Domains (1) summary

cl21453
Location:1 → 56

PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

204566371..204586053 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054338930.1 → XP_054194905.1 NUAK family SNF1-like kinase 2 isoform X1

UniProtKB/TrEMBL

Q68E04
XM_054338931.1 → XP_054194906.1 NUAK family SNF1-like kinase 2 isoform X2

UniProtKB/TrEMBL

Q68E04