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Nuak2 NUAK family, SNF1-like kinase, 2 [ Mus musculus (house mouse) ]

Gene ID: 74137, updated on 12-May-2024

Summary

Official Symbol
Nuak2provided by MGI
Official Full Name
NUAK family, SNF1-like kinase, 2provided by MGI
Primary source
MGI:MGI:1921387
See related
Ensembl:ENSMUSG00000009772 AllianceGenome:MGI:1921387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Snark; Omphk2; mKIAA0537; 1200013B22Rik
Summary
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to glucose starvation; negative regulation of apoptotic process; and protein phosphorylation. Predicted to act upstream of or within apoptotic process and phosphorylation. Predicted to be active in cytoplasm. Is expressed in several structures, including lung; neural ectoderm; nose; paravertebral ganglion; and ventricular layer. Human ortholog(s) of this gene implicated in anencephaly. Orthologous to human NUAK2 (NUAK family kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 25.5), small intestine adult (RPKM 23.1) and 19 other tissues See more
Orthologs
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Genomic context

See Nuak2 in Genome Data Viewer
Location:
1 E4; 1 57.24 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (132243827..132261233)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132316125..132333488)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02247 Neighboring gene predicted gene, 38446 Neighboring gene predicted pseudogene 7241 Neighboring gene kelch domain containing 8A Neighboring gene STARR-positive B cell enhancer ABC_E2009 Neighboring gene STARR-seq mESC enhancer starr_02251 Neighboring gene predicted gene, 30744 Neighboring gene VISTA enhancer mm505 Neighboring gene RIKEN cDNA F730311O21 gene Neighboring gene STARR-positive B cell enhancer ABC_E7749 Neighboring gene STARR-positive B cell enhancer ABC_E11087 Neighboring gene transmembrane and coiled-coil domains 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NUAK family SNF1-like kinase 2
Names
SNF1/AMP-activated protein kinase
omphalocele kinase 2
NP_001181954.1
NP_001403205.1
NP_083054.1
XP_006529972.1
XP_036009854.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195025.2NP_001181954.1  NUAK family SNF1-like kinase 2 isoform A

    See identical proteins and their annotated locations for NP_001181954.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AC160545
    Consensus CDS
    CCDS56642.1
    UniProtKB/Swiss-Prot
    Q80ZW3, Q8BZN4, Q8CIC0, Q9DBV0
    Related
    ENSMUSP00000072039.8, ENSMUST00000072177.14
    Conserved Domains (2) summary
    smart00220
    Location:57315
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:53315
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001416276.1NP_001403205.1  NUAK family SNF1-like kinase 2 isoform C

    Status: VALIDATED

    Source sequence(s)
    AC160545
  3. NM_028778.5NP_083054.1  NUAK family SNF1-like kinase 2 isoform B

    See identical proteins and their annotated locations for NP_083054.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) lacks an in-frame exon in the coding region, compared to variant A. This results in a shorter protein (isoform B), compared to isoform A.
    Source sequence(s)
    AC160545
    Consensus CDS
    CCDS15283.1
    UniProtKB/Swiss-Prot
    Q8BZN4
    Related
    ENSMUSP00000080769.6, ENSMUST00000082125.6
    Conserved Domains (2) summary
    smart00220
    Location:57307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14161
    Location:53307
    STKc_NUAK2; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    132243827..132261233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153961.1XP_036009854.1  NUAK family SNF1-like kinase 2 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1208
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006529909.3XP_006529972.1  NUAK family SNF1-like kinase 2 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:156
    PKc_like; Protein Kinases, catalytic domain